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  • 1
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 53 (1997), S. 331-334 
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: A new cellular growth factor termed augmenter of liver regeneration (ALR) has been crystallized. ALR has been shown to have a proliferative effect on liver cells while at the same time producing an immunosuppressive effect on liver-resident natural killer cells and liver-resident mononuclear leukocytes. In addition, ALR appears to play an important role in the synthesis and stabilization of mitochondrial gene transcripts in actively regenerating cells. ALR crystals diffract to beyond 2 Å resolution and belong to space group P21212, with a = 125.1, b = 108.1 and c = 38.5 Å. Based on four molecules per asymmetric unit, the Matthews coefficient is calculated to be 2.16 Å3 Da−1 which corresponds to a solvent content of 43%.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 946-949 
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: A modified neurophysin, des 1-6 bovine neurophysin II, has been crystallized in the absence of bound hormone or hormone analogue. These crystals represent the first crystals of ligand-free neurophysin, and are essential for understanding neurophysin–hormone recognition as well as hormone-induced neurophysin dimerization. The crystals diffract to beyond 1.8 Å resolution, belong to space group P3121 (or P3221) with a = 48.86, c = 78.61 Å, and contain one molecule per asymmetric unit.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 44 (1995), S. 0 
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: During 1993 and 1994 an unusual Phytophthora was consistently isolated from bark lesions at the stem bases of dying alder in Southern Britain. The Phytophthora resembles P. cambivora in both its gametangial and sporangial morphology. However, it is distinct from this species in being homothallic rather than outcrossing; in producing a significant proportion of small and sometimes partially developed oogonia; in having a high frequency of oosphere abortion; in having an appressed felty colony type with little or no aerial mycelium; and in exhibiting a lower optimum temperature for growth (c.22-5°C) and lower growth temperature maximum (c.29°C) on carrot agar than P. cambivora (c.27-5° and 33-5°C respectively). An inoculation test confirmed its pathogenicity to Alnus. The status of the alder Phytophthora is discussed. On the basis of its unusual characteristics and unusual host it is suggested that it might be a new or recently introduced organism rather than a previously unrecorded indigenous variant of P. cambivora.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Forest pathology 28 (1998), S. 0 
    ISSN: 1439-0329
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Forty-nine new poplar clones, bred in Belgium and screened there for resistance to bacterial canker caused by Xanthomonas populi, were additionally screened in southern England, using British isolates of the bacterium. Thirty-five of the test clones ranked better than the clone ‘Boelare’, which is already registered in the UK as an approved clone, and is regarded as having acceptable resistance. The registered clone ‘Ghoy’ was more susceptible, and outranked only four test clones. Preliminary measurements of canker length and stem girdling index showed differences between five bacterial isolates.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 86 (1999), S. 1611-1620 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have used transmission electron microscopy to study magnetization processes in Co/Cu multilayers with the Cu spacer layer thickness close to 9 Å. The films show giant magnetoresistance (GMR) values (approximate)25%, saturation fields of 1–2 kOe, and very little magnetoresistive hysteresis; they are of interest as position sensors. While the Cu thickness was chosen to correspond to the first antiferromagnetic maximum, magnetic images taken throughout a magnetization cycle attest to the fact that the antiferromagnetic coupling is far from complete. Detailed analysis of image sequences and the corresponding low angle diffraction patterns suggests that the coupling is dominated by a biquadratic component. This is consistent with the relatively low value of GMR. Furthermore, the well-defined and relatively simple domain processes which are observed over the low field regime (±50 Oe) explain why little hysteresis is observed. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: DNA flow cytometry has been extensively studied in female breast carcinoma. However, there is limited data evaluating DNA ploidy in male breast cancer. In order to further assess the prognostic significance of DNA ploidy in male breast carcinoma, we retrospectively reviewed 55 cases (52 patients) of histologically proven male breast carcinoma treated at our institution from January 1971 through January 1992. Of the 55 cases, 32 paraffin-embedded blocks were available for DNA flow cytometry analysis. As of June 1993, median follow-up is 7.0 years. In the overall population of 55 cases, univariate analysis identified TNM stage, tumor size, and nodal status as significant prognostic indicators of overall survival and disease-free survival. In the 32 cases available for DNA flow cytometry, both local recurrences and distant metastases were more frequent in the aneuploid population. Univariate analysis revealed DNA ploidy to be a significant prognostic factor for local recurrence-free survival and distant metastasis-free survival. DNA ploidy correlated significantly with stage at diagnosis (p =.04), tumor size (p =.04) and nodal status (p =.02). In a multivariate analysis of 26 patients on whom all data were available (DNA ploidy, tumor size, clinical stage and nodal status), DNA ploidy was an independent predictor of disease-free survival (p =.05). In this retrospective analysis, we conclude that DNA ploidy has prognostic significance in male breast carcinoma.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Heat and mass transfer 35 (1999), S. 479-485 
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The paper gives a brief description of some of the better understood aspects of condensation heat transfer and includes discussion of the liquid-vapour interface, natural and forced convection laminar film condensation and dropwise condensation.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-2218
    Keywords: Key words: Anastomotic leakage — Laparoscopic colorectal surgery — Multicenter study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: We report on a prospective observational multicenter study of more than 1,000 consecutive patients undergoing laparoscopic colorectal procedures. The aim of the current study was to investigate the safety of laparoscopic colorectal surgery as reflected by the anastomotic insufficiency rates in the various sections of the bowel, and to compare these rates with those of open colorectal surgery. Methods: The study was begun on August 1, 1995. Twenty-four centers in Germany, Austria, and Switzerland participated in this prospective multicenter study. All patients undergoing laparoscopic colorectal surgery were included in the study. No selection criteria were applied, which means that every operation begun as a laparoscopic procedure was included. Data on patient demographics, surgical indications, surgical course, and patient outcome were recorded prospectively in a computer database. All data were rendered anonymous. Results: Between August 1995 and February 1998, the 24 participating centers treated 1,143 patients (male/female ratio, 1:1.36; mean age, 60.7 years). In all, 626 operations were performed for benign indications and 517 for cancer. Most procedures involved the sigmoid colon and rectum (80.9%). An anastomosis was performed in 83% of the operations. Most of the anastomoses were laparoscopically assisted using the stapling technique. We observed an overall leakage rate of 4.25% (colon 2.9%; rectum 12.7%), and surgical reintervention was required in 1% of the cases. The rate of conversion to open surgery was 5.6%. Intraoperative complications occurred in 5.9%, and reoperation was necessary in 4.1% of the cases. The overall morbidity rate was 22.3%, and the 30-day mortality rate was 1.57%. Conclusions: The feasibility and safety of the laparoscopic colorectal approach is demonstrated clearly. The current study shows that the laparoscopic or laparoscopically assisted approach to colorectal surgery is not associated with a higher risk of anastomotic leaks. Morbidity and mortality rates with this method approximate those seen with conventional colorectal surgery.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0533
    Keywords: Key words Purkinje cells ; Blood-brain barrier ; Human anticerebellar antibody ; Rat ; Paraneoplastic syndromes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Paraneoplastic cerebellar degeneration accompanying gynecological or breast malignancies is frequently associated with an autoantibody response, termed "type I" or "anti-Yo" directed against cytoplasmic antigens of cerebellar Purkinje cells. The role of this antibody response in the pathogenesis of paraneoplastic cerebellar degeneration is unknown; however, it is also not known whether anti-Purkinje cell antibodies from the systemic circulation bind to targe t Purkinje cell antigens under the conditions of brain inflammation and blood-brain barrier disruption, which are frequently present at the onset of cerebellar symptoms. Inbred Lewis rats received intraperitoneal injections of type I or normal IgG in the setting of blood-brain barrier disruption induced by adoptive transfer of experimental allergic encephalomyelitis (EAE) and were killed after 24, 48, and 96 h. Brains of these animals were studied histologically for evidence of EAE and immunohistochemically for binding of human or endogenous rat IgG to target neurons. Rat IgG was detected around vessels and in Purkinje cells of all animals studied. Human IgG was detected around vessels of all animals. In animals examined 96 h after receiving type I human IgG, human IgG was identified within processes of Purkinje cells and within occasional Purkinje cell bodies. Uptake of type I IgG by other cell types was not observed, and neuronal uptake of IgG was not seen in brains of animals receiving normal human IgG. Ou r data demonstrate that circulating type I IgG is internalized by cerebellar Purkinje cells in the setting of blood-brain barrier disruption and suggest a mechanism by which an antibody response directed against cytoplasmic antigens of Purkinje cells may reach target antigens at the onset of paraneoplastic cerebellar degeneration.
    Type of Medium: Electronic Resource
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