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  • 1
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Secretoneurin (SN) is a neuropeptide derived from secretogranin II that is found in brain and endocrine tissues. The aim of the present study was to determine the influence of this novel peptide on dopamine (DA) release from rat striatum using the microdialysis technique. Rat SN (1–30 µmol/L added to the dialysis buffer) enhanced DA outflow of awake rats in a concentration-dependent way without marked effects on the outflow of 3,4-dihydroxyphenylacetic acid or homovanillic acid. The increase in extracellular DA content caused by the peptide was observed throughout the entire period of administration (up to 4 h). Human SN and its 15-amino-acid C-terminal sequence also increased DA outflow, but the effects were smaller than those of rat SN. Two other peptides derived from secretogranin II were without effect on DA efflux. These results establish that SN has a pronounced effect on DA release under in vivo conditions.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Secretoneurin is a recently described peptide derived by endoproteolytic processing from secretogranin II, previously named chromogranin C. In this study, we have investigated the distribution of secretoneurin-like immunoreactivity in the human hippocampus in controls and in Alzheimer's disease patients, and compared the staining pattern to that of calretinin. Secretoneurin-like immunoreactivity is present throughout the hippocampal formation. At the border of the dentate molecular layer and the granule cell layer, a band of dense secretoneurin immunostaining appeared. In this part, as in the area of the CA2 sector, the high density of secretoneurin-immunoreactivity coincided with calretinin-like immunoreactivity. The mossy fibre system displayed a moderate density of secretoneurin-immunoreactivity. In the entorhinal cortex, a particularly high density of secretoneurin-immunoreactivity was observed. The density of secretoneurin-like immunoreactivity was significantly reduced in the innermost part of the molecular layer and in the outer molecular layer of the dentate gyrus in Alzheimer's disease. For calretinin-like immunoreactivity, a less pronounced decrease was found in the innermost part of the molecular layer. About 40–60% of neuritic plaques were secretoneurin-immunopositive.This study shows that secretoneurin is distinctly distributed in the human hippocampus and that significant changes of secretoneurin-like immunoreactivity occur in Alzheimer's disease, reflecting synaptic loss.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 8 (1996), S. 0 
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An antiserum was raised against the peptide PE-11 whose sequence is present in the chromogranin B molecule. The antiserum reacts only with the free C-terminal end of this peptide. PE-11 immunoreactivity in brain was characterized by molecular size exclusion high performance liquid chromatography. Only the free peptide and a N-terminally elongated peptide were detected, indicating that proteolytic processing of chromogranin B in brain is quite extensive. In immunohistochemistry PE-11 immunoreactivity was found in varicosities, fibres and perikarya throughout the brain. Strong staining was detected in the shell sector of the nucleus accumbens, in the lateral septum, in subregions of the extended amygdala, in some areas of the hippocampus and of the hypothalamus, in the locus coeruleus, in the Purkinje cells of the cerebellum and in the dorsal horn of the spinal cord. Our results, which demonstrate significant processing of chromogranin B in brain and its widespread distribution, can be taken as an indication that chromogranin B represents a precursor of peptides with functional relevance for this organ.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Ecology of freshwater fish 4 (1995), S. 0 
    ISSN: 1600-0633
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract– The mechanisms leading to spatial segregation along optical habitat dimensions in closely related, co-occurring fishes were investigated. In two experimental series, six laboratory-reared cyprinid species were faced to six novel optical patterns. These were positioned either laterally, at the bottom, or at the water surface, in one of three compartments of a large tank. When a bottom pattern was presented, the primarily bottom-dwelling species Vimba elonguta and Abranzis brama chose the test compartment at high frequencies, indicating a significant preference. More surface-oriented species like Chalcalburnus chalcoides mento and Scardinius erythrophthalmus developed similar preferences in response to surface patterns. V. elongata, A. brama, and Rutilus rutilus showed significant preferences for a photograph of submerged plants. Also, V. elongata developed preferences for several optical patterns. These data confirm earlier studies on V. elongata habitat selection and foraging behaviour which suggest a highly exploratory lifestyle. S. erythrophthalmus and Leuciscus cephalus showed significant avoidances for laterally positioned optical patterns associated with reduced interindividual distances, indicating marked neophobic responses. The establishment of species-specific preferences or avoidances during the two experimental series was influenced by learning processes.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature medicine 1 (1995), S. 869-873 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Pioneers in xenotransplantation (transplantation of organs from one species to another) abandoned their efforts decades ago largely because of the generally poor results obtained and because of the emergence of clinical allotransplantation. Currently, interest in xenotransplantation research is ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 171 (1958), S. 286-287 
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 172 (1957), S. 105-120 
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es werden Normtonsillektomien unter Verwendung von Adrenalin mit Mandelausschälungen, die unter Hexamethoniumwirkung durchgeführt wurden, verglichen. Auf die nicht unwesentliche rolle psychischer Faktoren bei der Blutdruckgestaltung intra operationem wird hingewiesen. Eine ausreichende Blutarmut läßt sich bei Verwendung von 2,5 mg Hexamethonium intramuskulär pro kg Körpeergewicht erzielen. Es ist wünschenscwert, den Blutdruck auf Werte, die bei etwa 60–50 mm Hg liegen, zu senken. Vorteile des Verfahrens sind die zumeist geringe Blutung während der Operaation sowie fast trockene Wundverhältnisse nach beendeter Tonsillektomie bei häufig geringer Gewebsreaktion und unter dem Durchschnitt liegenden postoperativen Beschwerden. Nachteilig wirken sich der größere technische Aufwand und ein durch die Hirnanoxie hervorgerufener inkonstanter, aber nicht immer unerheblicher Würg- und Brechreiz aus.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    International urogynecology journal 9 (1998), S. 100-102 
    ISSN: 1433-3023
    Keywords: Bladder ; Oxybutynin ; Urinary incontinence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our aim was to determine whether oxybutynin hydrochloride suppositories can be used as a treatment for detrusor instability in patients who have not been able to tolerate oral pharmacological agents. A retrospective chart review of 25 women diagnosed with detrusor instability and treated with oxybutynin rectal suppositories was conducted. Each suppository contained 5 mg oxybutynin, 15 mg micronized Sila gel, and 1.25 g of a fatty acid base. Patients were started on one suppository twice daily and then dose titrated as tolerated. The range of the total daily dose was 5–20 mg. Nine of 25 women (36%) had greater than a 50% overall subjective improvement and 3 (12%) had some improvement. Seven of the 12 responders (58%) continued to use the suppositories for a prolonged period of time (〉90 days). The most common side effects reported were dry mouth 48% and constipation 14.3%. One patient with polymyositis developed a serious anticholinergic reaction which required hospitalization. It was concluded that patients who are unable to tolerate oral anticholinergic and antispasmodic agents for the treatment of detrusor instability may benefit from oxybutynin rectal suppositories.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1434-6036
    Keywords: PACS. 63.20.Dj Phonon states and bands, normal modes, and phonon dispersion - 76.80.+y Mössbauer effect; other -ray spectroscopy - 39.30.+w Spectroscopic techniques
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: Mössbauer studies were performed on single crystals of guanidinium nitroprusside with different orientations of their principal crystallographic axes (a, b, c) with respect to the incident radiation. The markedly anisotropic Lamb-Mössbauer factor f LM , i.e. f LM (a) = 0.118(8), f LM (b) = 0.174(8), f LM (c) = 0.202(8) is in contrast to that of nitroprussides with inorganic anions. The observed anisotropy is ascribed to the anisotropic vibrational mean-square displacement of the nitroprusside anions as a whole which is due to the specific packing of both, anions and cations, as well as the very weak chemical bonding between the ions, typical only for guanidinium nitroprusside. The vibrational anisotropy of iron atoms in barium nitroprusside that has been observed by X-ray structural investigations has a different origin and therefore does not result in an anisotropic Lamb-Mössbauer factor. We have also investigated metastable states in guanidinium nitroprusside that have been populated by means of incoherent irradiation from light-emitting diodes. With a specific orientation of the guanidinium nitroprusside single crystal a population of the metastable states up to 26% could be achieved. Populations of comparable size on lithium, sodium and potassium nitroprussides have only been reached using coherent laser irradiation.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für angewandte Mathematik und Physik 10 (1959), S. 438-441 
    ISSN: 1420-9039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Type of Medium: Electronic Resource
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