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Value of magnetic resonance imaging with an endovaginal receiver coil in the pre-operative assessment of Stage I and IIa cervical neoplasia (1998)

DeSouza, N. M. ; McIndoe, G. A. J. ; Soutter, W. P. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

BJOG 105 (1998), S. 0

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ISSN: 1471-0528

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Objective To assess the value of high resolution endovaginal magnetic resonance images (MRI) of the uterine cervix in planning management of early cervical cancer.Design Prospective cross-sectional study.Setting Specialist gynaecological oncology unit of a postgraduate teaching hospital.Participants Thirty nine women aged 25–76 years old (mean 42.5 years) with invasive carcinoma Stage I or IIa of the cervix.Methods A ring coil was positioned endovaginally around the cervix. Imaging was performed on a 1.0 T HPQ Vista or 0.5 T Asset (Picker, Highland Heights, Ohio, USA) using T1 weighted and T2 weighted sequences in transverse and sagittal planes with thin slices (2.5 mm) and small fields of view (12 cm). Tumour volumes were measured and any extension into adjacent organs and parametrium was noted. The patients were followed up after treatment and the outcome related to the MRI findings.Results There was one false positive and one false negative result among five Stage Ia patients being assessed for residual disease after cone biopsy or LLETZ. The MRI assessment of the size and distribution of the tumour was confirmed histologically in all 31 patients with Stage Ib or IIa disease who were treated surgically. One of these patients in whom no endocervical tumour was visible on MRI underwent radical trachelectomy. Three patients had radiotherapy as primary treatment. Patients with Stage Ib or IIa disease who had tumour volumes 〉 10 cm3 with early parametrial extension on MRI had a substantially worse prognosis at 24 months (disease-free survival 58.3% vs 95.5%, P= 0.003).Conclusion High resolution MRI with an endovaginal coil allows precise measurement of tumour volume and identifies patients with small volume disease who might be considered for more conservative therapy. This technique also reveals early parametrial invasion that cannot be identified reliably by any other method. Early parametrial invasion in women with large tumours appears to have a very much worse prognosis.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1471-0528.1998.tb10149.x

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Spherical grating monochromator with interferometer control and in-vacuum reference : Papers from the 12th National Synchrotron Radiation Instrumentation Conference (2002)

Holly, D. J. ; Mason, W. P. ; Sailor, T. ; [et al.]

[S.l.] : American Institute of Physics (AIP)

Review of Scientific Instruments 73 (2002), S. 1530-1532

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ISSN: 1089-7623

Source: AIP Digital Archive

Topics: Physics , Electrical Engineering, Measurement and Control Technology

Notes: Physical Science Laboratory's new generation of spherical grating monochromators incorporates a laser interferometer to control scan angle and an in-vacuum absolute angle reference, as well as other improvements. The design accommodates up to six gratings which can be moved axially (under motor control, with encoder position readback) at any scan angle. The gratings are cooled by means of spring-loaded clamps which conduct heat to a water-cooled plate. The instruments feature hollow roller bearings on the scan axis to minimize bearing runout, and a pseudosine-bar drive for precise control of grating angle. The interferometer angle-measuring optics are mounted inside the vacuum chamber and measure the angle between the grating scan axis and the instrument's granite base. The laser interferometer measures the grating angle with a resolution of approximately 0.02 arcsec over the entire scan range of 40°. To provide a reference for the interferometer angle measurement, we have built an in-vacuum optical reference which uses custom chrome-on-glass reticles mounted inside the vacuum chamber. Collimated light from a source outside the vacuum passes through the reticles to yield quadrature signals which precisely define an absolute reference angle for the interferometer. Repeatability of the grating angle is within a range of ±0.05 arcsec. Two of these instruments are in operation at SRRC (Taiwan) and a third instrument has been delivered to NSLS (Brookhaven). © 2002 American Institute of Physics.