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  • 1
    Digitale Medien
    Digitale Medien
    Development of an STS marker and SSRs suitable for marker-assisted selection for the BaMMV resistance gene rym9 in barley (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 119 (2000), S. 0 
    Details
    ISSN: 1439-0523
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Based on the RAPD marker OP-C04H910 which is closely linked to the barley mild mosaic virus (BaMMV) resistance gene rym9 derived from the variety ‘Bulgarian 347’ the marker STS-C04H910 cosegregating with OP-C04H910 and generating a single additional band on plants carrying the recessive resistance encoding allele has been developed. Furthermore, the simple sequence repeats (SSRs) WMS6 and HVM67 have been integrated into the genetic map of the rym9 region on chromosome 4HL. Because of their close linkage to rym9 and distinct banding pattern STS-C04H910 and HVM67 are well-suited for marker- assisted selection, enhanced backcrossing procedures and pyramiding of resistance genes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1439-0523.2000.00520.x
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  • 2
    Digitale Medien
    Digitale Medien
    Localization of the A kinase anchoring protein AKAP79 in the human hippocampus (2000)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 12 (2000), S. 0 
    Details
    ISSN: 1460-9568
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The phosphorylation state of the proteins, regulated by phosphatases and kinases, plays an important role in signal transduction and long-term changes in neuronal excitability. In neurons, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and calcineurin (CN) are attached to a scaffold protein, A kinase anchoring protein (AKAP), thought to anchor these three enzymes to specific sites of action. However, the localization of AKAP, and the predicted sites of linked phosphatase and kinase activities, are still unknown at the fine structural level. In the present study, we investigated the distribution of AKAP79 in the hippocampus from postmortem human brains and lobectomy samples from patients with intractable epilepsy, using preembedding immunoperoxidase and immunogold histochemical methods. AKAP79 was found in the CA1, presubicular and subicular regions, mostly in pyramidal cell dendrites, whereas pyramidal cells in the CA3, CA2 regions and dentate granule cells were negative both in postmortem and in surgical samples. In some epileptic cases, the dentate molecular layer and hilar interneurons also became immunoreactive. At the subcellular level, AKAP79 immunoreactivity was present in postsynaptic profiles near, but not attached to, the postsynaptic density of asymmetrical (presumed excitatory) synapses. We conclude that the spatial selectivity for the action of certain kinases and phosphatases regulating various ligand- and voltage-gated channels may be ensured by the selective presence of their anchoring protein, AKAP79, at the majority of glutamatergic synapses in the CA1, but not in the CA2/CA3 regions, suggesting profound differences in signal transduction and long-term synaptic plasticity between these regions of the human hippocampus.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1460-9568.2000.00002.x
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  • 3
    Digitale Medien
    Digitale Medien
    Multicopy single-stranded DNA of Escherichia coli enhances mutation and recombination frequencies by titrating MutS protein (1996)
    Oxford BSL : Blackwell Science Ltd
    Molecular microbiology 19 (1996), S. 0 
    Details
    ISSN: 1365-2958
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: Multicopy single-stranded DNA (msDNA) molecules consist of single-stranded DNA covalently linked to RNA. In Escherichia coli, such molecules are encoded by genetic elements called retrons. The DNA moieties of msDNAs have characteristic stem-loop structures, and most of these structures contain mismatched base pairs. Previously, we showed that retrons encoding msDNAs with mismatched base pairs are mutagenic when present in multicopy plasmids. In this study we show that such msDNAs, in a similar manner to genetic defects in mismatch repair, increase the frequency of interspecies recombination in matings between Salmonella typhimurium and E. coli. To demonstrate interference with mismatch repair by msDNA, we show that the addition of a plasmid containing the gene for MutS protein suppresses the mutagenic and recombinogenic effects of msDNAs. We also show that in mutS mutants, msDNA does not increase the frequency of either mutations or interspecies recombination. We conclude from these findings that the mutagenic and recombinogenic effects of msDNAs are due to titrating out MutS protein.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2958.1996.392921.x
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  • 4
    Digitale Medien
    Digitale Medien
    Stimulation of cell division in the rat by NaCl, KCl, MgCl2, and CaCl2, and inhibition of the sodium chloride effect on the glandular stomach by ascorbic acid and β-carotene (1999)
    Springer
    Journal of cancer research and clinical oncology 125 (1999), S. 209-213 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Key words Cell division ; Stomach ; Neoplasms ; Sodium chloride ; Ascorbic acid ; β-carotene
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Three questions associated with the stimulation of cell division by chloride salts have been investigated: (i) whether cations other than sodium show a similar effect, (ii) whether vitamins can have a preventive activity, and (iii) whether subchronic treatment with sodium chloride in the diet is also effective. Male Fischer 344 rats were given solutions of the chloride salts of sodium, potassium, magnesium, and calcium by oral gavage. Water was used for control. After 4 h, a 24-h osmotic minipump containing 5-bromo-2′-deoxyuridine was implanted subcutaneously. The forestomach and glandular stomach, as well as liver and bladder were analyzed immunohistochemically 24 h later for the proportion of cells in S phase as an indicator of the rate of replicative DNA synthesis. For both the forestomach and the glandular stomach, potassium was as potent as sodium, and the divalent cations Mg and Ca were even more potent on a molar basis. Supplementation of the diet with ascorbic acid (2 g/kg food) or β-carotene (12.5 mg/kg food) for 1 week before gavage of the sodium chloride solution resulted in an inhibition of the stimulation of cell division. A putative tumor-chemopreventive activity of the two vitamins might therefore not only rely on their antioxidative properties but may include effects on the cell cycle. A 4-week treatment with a sodium chloride supplement in the diet (2% and 4% supplement) resulted in a significant stimulation of cell division not only in both parts of the stomach and in the bladder (with the 4% supplement) but also in the liver (even with the 2% supplement). Sodium-chloride-stimulated cell turnover therefore is a sustained effect.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004320050264
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  • 5
    Digitale Medien
    Digitale Medien
    Endogenous and exogenous factors in carcinogenesis: limits to cancer prevention (1996)
    Springer
    International archives of occupational and environmental health 68 (1996), S. 120-125 
    Details
    ISSN: 1432-1246
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Organ-specific cancer incidence rates can vary dramatically between low- and high-incidence areas. Such differences are due to (1) heritable susceptibility determinants, (2) risk factors associated with the environmental and local living conditions (e.g., viruses, pollution), and (3) personal life-style factors. For organs showing large differences between cancer registries, exogenous factors might be most important, while for organs showing only small differences, endogenous and unavoidable factors are expected to be more important. In this paper, a working hypothesis based on descriptive cancer epidemiology is presented to estimate, in a quantitative manner, the unavoidable contribution to the process of carcinogenesis and to discuss limitations to individual cancer prevention. Cumulative cancer incidence rates for a 75-year period of life (CR74, in percent) were taken from IARC Scientific Publication No. 120 (1992). For each organ, values were ranked in ascending order, and the ratio between high-rate and low-rate registries (90th percentile/10th percentile) was determined. This measure of variability among registries differed strongly between organs. Largest ratios were seen for organs with well-known exogenous risk factors, such as pharynx, lip, tongue, mouth, liver, esophagus, and melanoma in males, and lung, esophagus, gallbladder, liver, and bladder in females. Small ratios were seen for rectum, brain, colon, and Hodgkin's disease in males, and breast, rectum, ovary, brain, and colon in females. It is concluded that the process of carcinogenesis in the latter organs has a stronger endogenous/unavoidable component, for some tissues possibly of hormonal type. A fictitious population was composed where, for each organ, the minimum reported cancer rate was taken. When based on all cancer registries world-wide, CR74 sums over all sites of 2.0% and 2.3% resulted in males and females, respectively. When only Central/Western European countries were included in the analysis in order to reduce differences in risk factors nos, 1 and 2, the sum of the minimum values was 10.4% and 8.7%. After correction of the data for smoking, ‘minimum’ cancer incidence rates in males and females were estimated to be 7.6% and 6.8%. Based on a median cancer incidence rate for nonsmoking males in Europe of about 21%, therefore, individual preventive measures taken by a nonsmoker can reduce the cancer risk, on average, ‘only’ by a factor of about 3. A considerable fraction of cases thus appears to be hardly avoidable.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00381244
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  • 6
    Digitale Medien
    Digitale Medien
    Frontal brain activation during the Wisconsin Card Sorting Test assessed with two-channel near-infrared spectroscopy (1998)
    Springer
    European archives of psychiatry and clinical neuroscience 248 (1998), S. 245-249 
    Details
    ISSN: 1433-8491
    Schlagwort(e): Key words NIRS ; WCST ; Mental activation ; Laterality
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Near-infrared spectroscopy (NIRS) is a new non-invasive optical technique suitable to assess the concentration changes of oxygenated (O2HB) and deoxygenated (HHB) hemoglobin in brain tissue. Previous NIRS studies showed distinct patterns of blood oxygenation changes during different cognitive tasks. In particular, bilateral frontal hypo-oxygenation was found during reading, right frontal hyper-oxygenation during the Continuous Performance Test, and left frontal hyper-oxygenation during the Verbal Fluency Test. The Wisconsin Card Sorting Test (WCST) is a neuropsychological test which is presumed to activate prevalently the frontal lobes. This was demonstrated by lesion studies and functional imaging (single photon emission computed tomography and positron emission tomography). In the present study, a two-channel NIRS system was applied to investigate frontal brain areas of ten healthy subjects during performance of the WCST. A significant bilateral increase of O2HB in frontal brain regions without hemispheric differences was found during the WCST compared with a baseline at rest. This result indicates an enhanced perfusion of the frontal lobes consistent with local activation. The findings add further evidence that the NIRS technique is sensitive enough to detect physiological blood oxygenation changes. Furthermore, a comparison with previous studies revealed an activation pattern distinct from those observed during other cognitive tasks. It is concluded that the results reflect local responses to specific task demands of the WCST.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004060050045
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  • 7
    Digitale Medien
    Digitale Medien
    The string model for ultrarelativistic nuclear scattering (1995)
    Springer
    Czechoslovak journal of physics 45 (1995), S. 591-609 
    Details
    ISSN: 1572-9486
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract We review basic theoretical concepts to describe nuclear collisions at ultrarelativistic energies. We discuss relativistic strings, Gribov-Regge theory (GRT) of hadronic interactions and string models based on GRT, and finally generalizations to nucleus-nucleus scattering.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01688547
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  • 8
    Digitale Medien
    Digitale Medien
    Influence of long-term conservation tillage on soil and rhizosphere microorganisms (1999)
    Springer
    Biology and fertility of soils 29 (1999), S. 81-86 
    Details
    ISSN: 1432-0789
    Schlagwort(e): Key words Soil tillage ; Rhizosphere microorganisms ; Cereals ; Nitrogen fixation ; Gaeumanomyces graminis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Geologie und Paläontologie , Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Abstract  In long-term field experiments on sandy loam and loamy sand soils, the influence of conservation and conventional tillage on soil and rhizosphere microorganisms was studied. Conservation tillage stimulated rhizosphere bacteria on winter wheat, winter barley, winter rye and maize in different soil layers. Particularly the populations of Agrobacterium spp. and Pseudomonas spp. were increased. On the sandy loam, N2 fixation and nodulation of pea plants were significantly increased. No influence of different soil tillage was determined on the colonization of the rhizosphere by mycorrhiza and saprophytic fungi. Stubble residues infected with Gaeumanomyces graminis were infectious for a longer time on the soil surface than after incorporation into the soil.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s003740050528
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  • 9
    Digitale Medien
    Digitale Medien
    Study of the analytical solution to the heat transfer problem and surface temperature in a semi-infinite body with a constant heat flux at the surface and an initial temperature distribution (1995)
    Springer
    Heat and mass transfer 30 (1995), S. 183-186 
    Details
    ISSN: 1432-1181
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Physik
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung In vielen praktischen Fällen erhitzt man einen halbunendlichen Festkörper mit einer konstanten Wärmestromdichte an der Oberfläche. Im Fall einer einheitlichen Anfangstemperatur des Körpers wurde eine analytische Lösung zu diesem instationären Wärmetransportproblem von Carslaw und Jäger gegeben. Die Oberflächentemperatur des unendlichen Festkörper verläuft nach der $$\sqrt t $$ -Regel. Das heißt, die Oberflächentemperatur ändert sich proportional zur Wurzel der Erhitzungszeit. Im Fall der uneinheitlichen Anfangstemperatur des Körpers wurde noch keine analytische Lösung entwickelt. In diesem Aufsatz werden analytische Lösungen zu diesem instationären Problem mit einer exponentiellen oder einer linearen Anfangstemperaturverteilung gegeben. Es zeigt, daß im Fall der linearen Anfangstemperatureverteilung die Oberflächentemperatur der $$\sqrt t $$ -Regel folgt. Für eine beliebige Anfangstemperaturverteilung kann man sie in der Nähe von der Oberfläche mit ihrer Tangente an der Oberfläche linearisieren, deshalb gilt auch hier die $$\sqrt t $$ -Regel. Die Meßdaten unterstützen dieses Argument. Außerdem wurde ein Verhältnis zwischen der Oberflächentemperatur und der Erhitzungszeit ermittelt, aus dem die konstante Wärmestromdichte berechnet werden kann. Dieses Verhältnis wurde in diesem Aufsatz für eine bekannte Anfangstemperaturverteilung oder für eine bekannte erste Ableitung der Anfangstemperaturverteilung an der Oberfläche abgeleitet.
    Notizen: Abstract In many practical cases, one heats a semi-infinite solid with a constant heat flux source. For such an unsteady heat transfer problem, if the body has a uniform initial temperature, the analytical solution has been given by Carslaw and Jaeger. The surface temperature of the semi-infinite body follows the $$\sqrt t $$ -rule, that is, the surface temperature changes in proportion to square root of heating time. But if, instead of the uniform initial temperature, the body has a temperature distribution at the beginning of heating, the analytical solution has not yet been developed. Analytical solutions to the same problem with an exponential or a linear initial temperature distribution are obtained in this paper. It is shown, that in the case of a linear initial temperature distribution the surface temperature also changes according to $$\sqrt t $$ -rule Approximating the initial temperature distribution near the surface by its tangent at the surface, it is found that the surface temperature within a short time after the start of heating should also satisfy the $$\sqrt t $$ -rule, in spite of an arbitrary initial temperature distribution. The experimental data support this argument. Furthermore, the constant heat flux can be calculated after relationship between the surface temperature and heating time according to the equation derived in this paper, if the initial temperature distribution or its first-order derivative at the surface is known.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01476528
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  • 10
    Digitale Medien
    Digitale Medien
    Study of the analytical solution to the heat transfer problem and surface temperature in a semi-infinite body with a constant heat flux at the surface and an initial temperature distribution (1995)
    Springer
    Heat and mass transfer 30 (1995), S. 183-186 
    Details
    ISSN: 1432-1181
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Physik
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung In vielen praktischen Fällen erhitzt man einen halbunendlichen Festkörper mit einer konstanten Wärmestromdichte an der Oberfläche. Im Fall einer einheitlichen Anfangstemperatur des Körpers wurde eine analytische Lösung zu diesem instationären Wärmetransportproblem von Carslaw und Jäger gegeben. Die Oberflächentemperatur des unendlichen Festkörper verläuft nach der √—t-Regel. Das heißt, die Oberflächentemperatur ändert sich proportional zur Wurzel der Erhitzungszeit. Im Fall der uneinheitlichen Anfangstemperatur des Körpers wurde noch keine analytische Lösung entwickelt. *In diesem Aufsatz werden analytische Lösungen zu diesem instationären Problem mit einer exponentiellen oder einer linearen Anfangstemperaturverteilung gegeben. Es zeigt, daß im Fall der linearen Anfangstemperaturverteilung die Oberflächentemperatur der √—t-Regel folgt. *Für eine beliebige Anfangstemperaturverteilung kann man sie in der Nähe von der Oberfläche mit ihrer Tangente an der Oberfläche linearisieren, deshalb gilt auch hier die √—t-Regel. Die Meßdaten unterstützen dieses Argument. *Außerdem wurde ein Verhältnis zwischen der Oberflächentemperatur und der Erhitzungszeit ermittelt, aus dem die konstante Wärmestromdichte berechnet werden kann. Dieses Verhältnis wurde in diesem Aufsatz für eine bekannte Anfangstemperaturverteilung oder für eine bekannte erste Ableitung der Anfangstemperaturverteilung an der Oberfläche abgeleitet.
    Notizen: Abstract In many practical cases, one heats a semi-infinite solid with a constant heat flux source. For such an unsteady heat transfer problem, if the body has a uniform initial temperature, the analytical solution has been given by Carslaw and Jaeger. The surface temperature of the semi-infinite body follows the √—t-rule, that is, the surface temperature changes in proportion to square root of heating time. But if, instead of the uniform initial temperature, the body has a temperature distribution at the beginning of heating, the analytical solution has not yet been developed. *Analytical solutions to the same problem with an exponential or a linear initial temperature distribution are obtained in this paper. It is shown, that in the case of a linear initial temperature distribution the surface temperature also changes according to √—t-rule. *Approximating the initial temperature distribution near the surface by its tangent at the surface, it is found that the surface temperature within a short time after the start of heating should also satisfy the √—t-rule, in spite of an arbitrary initial temperature distribution. The experimental data support this argument. *Furthermore, the constant heat flux can be calculated after relationship between the surface temperature and heating time according to the equation derived in this paper, if the initial temperature distribution or its first-order derivative at the surface is known.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01476528
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