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  • 1995-1999  (1)
  • 1985-1989  (3)
  • 1
    Digitale Medien
    Digitale Medien
    A neuropathological subset of Alzheimer's disease with concomitant Lewy body disease and spongiform change (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 194-201 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Alzheimer disease ; Diffuse Lewy body disease ; Spongiform change ; Creutzfeldt-Jakob disease
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The neuropathological heterogeneity of Alzheimer's disease (AD) is increasingly recognized. Diffuse Lewy body disease, for example, most frequently occurs in cases fulfilling histopathological criteria for AD, and these patients usually present with dementia rather than parkinsonism. We report five cases of concomitant AD and diffuse Lewy body disease with still another coexistent neuropathological feature: localized and stereotyped spongiform change in the neuropil. This spongiform change was most striking in the superior and inferior temporal, entorhinal, and insular cortex and the amygdala and was virtually indistinguishable from that seen in Creutzfeldt-Jakob disease. Electron microscopic study on one case revealed membrane-containing vacuoles in close association with neuritic plaques and plaired helical filament-filled processes. Immunocytochemistry using antibodies to prion proteins (PrPsc or PrP27–30) failed to label plaque or vascular amyloid in the five cases. Four primates inoculated with brain tissue from one case have not evidenced neurological disease in the 3 years since the transmission experiment. We conclude that these cases represent a neuropathological subset of AD with relatively widespread Lewy bodies and a localized spongiform change, predominantly involving the medial temporal region. Despite the light and electron microscopic commonality with Creutzfeldt-Jakob disease, there is no clear evidence that these cases represent a form of transmissible spongiform encephalopathy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00688209
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  • 2
    Digitale Medien
    Digitale Medien
    Isotretinoin teratogenicity (1985)
    Springer
    Acta neuropathologica 65 (1985), S. 335-337 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Isotretinoin ; Retinoic acid ; Hydrocephalus ; Teratogen
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Isotretinoin, a drug used for the treatment of acne, has been shown to have teratogenic effects. We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts. These findings are related to those reported previously.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00687018
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  • 3
    Digitale Medien
    Digitale Medien
    The dynamics of benthic microbial communities at Davies Reef, central Great Barrier Reef (1987)
    Springer
    Coral reefs 6 (1987), S. 63-70 
    Details
    ISSN: 1432-0975
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Geologie und Paläontologie
    Notizen: Abstract The dynamics of benthic microbial communities were examined within different functional zones (reef crest, reef flat, lagoon) of Davies Reef, central Great Barrier Reef, in winter. Bacterial numbers did not change significantly across the reef with a mean abundance $$(\bar x{\text{ }} \pm {\text{ 1 SE)}}$$ of 1.3 (±0.6) x 109 cells g-1 DW of sediment. Bacterial production, measured as thymidine incorporation into DNA, ranged from 1.2 (±0.2) to 11.6 (±1.5) mg C m-2h-1 across the reef and was significantly lower in a reef crest basin than in the other zones. Bacterial growth rates (μ) across the reef (0.05 to 0.33 g-1) correlated only with sediment organic carbon and nitrogen. Protozoan and meiofaunal densities varied by an order of magnitude across the reef and correlated with one or more sediment variables but not with bacterial numbers or growth rates. Nutrient flux rates were similar to those found at other reefs in the central and southern Great Barrier Reef and are significantly lower than rates measured in temperate sand communities. In the front lagoon, bioturbation and feeding acitivity by thalassinid shrimps (Callianassa spp.) negatively influenced microbial and meiofaunal communities with a net import of organic matter necessary to support the estimated rates of bacterial productivity. In lagoonal areas not colonized by shrimps, primary productivity (400–1100 mg C m-2d-1) from algal mats was sufficient to support bacterial growth. It is suggested that deposit-feeding macrobenthos such as thalassinid crustaceans play a major role in the tructuring and functioning of lower trophic groups (bacteria, microalgae, protozoa, meiofauna) in coral reef sedments, particularly in laggons.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00301375
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  • 4
    Digitale Medien
    Digitale Medien
    Correlation of nicotinic binding with neurochemical markers in Alzheimer's disease (1998)
    Springer
    Journal of neural transmission 105 (1998), S. 709-717 
    Details
    ISSN: 1435-1463
    Schlagwort(e): Keywords: Nicotinic receptor ; binding ; Alzheimer's disease.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary. The loss of neocortical synapses that occurs in Alzheimer's disease (AD) has been shown to correlate with cognitive decline. In addition, marked losses in the cholinergic system in AD, specifically choline acetyltransferase (ChAT) activity and high affinity presynaptic neuronal nicotinic cholinergic receptors (nAChRs), have also been described. We hypothesized that in AD, the loss of [3H]-ligand binding to nAChRs, which are largely presynaptic, would correlate with changes in two other presynaptic markers: synaptophysin (Syn), a measure of synaptic density, and ChAT activity. The midfrontal (MF) cortex of 36 autopsy confirmed (NIA and CERAD criteria) AD patients (mean death age ± SD 80.1 ± 8.4 years) who met NINDS-ADRDA criteria for a clinical diagnosis of probable or possible AD, and 11 nondemented controls (mean death age ± SD 77.9 ± 8.0) were examined. Synapse counts were quantified by a dotimmunobinding assay for Syn. ChAT activity was assessed by standard biochemical assays. Nicotinic cholinergic receptor binding was assayed using the high affinity nicotinic agonist [3H]- (±)-epibatidine ([3H]-EPI). The mean ± SD Syn in AD (83.4 ± 31.9 arbitrary units (AU)/mg protein) was significantly lower than controls (126.1 ± 19.9, p = 0.0003; t-test). The mean ChAT activity in AD (139.0 ± 75.6 nmol ACh/hr/100 mg protein) was significantly lower than controls (219.6 ± 70.8, p = 0.004). The mean [3H]-EPI total binding in AD (6.2 ± 2.8 fmol/mg protein) was significantly lower than controls (14.8 ± 3.2; p 〈 0.0001). Syn correlated with [3H]-EPI binding in AD (r = 0.48, p = 0.006; Pearson) but ChAT did not (r = −0.20, p = 0.34). We conclude that loss of high affinity nAChR binding correlates with loss of synapses in AD. The lack of correlation between [3H]-EPI binding and ChAT activity suggests that the targeted receptor populations may not be located exclusively on cholinergic neurons.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s007020050090
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