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  • 1
    Electronic Resource
    Electronic Resource
    Isotretinoin teratogenicity (1985)
    Springer
    Acta neuropathologica 65 (1985), S. 335-337 
    Details
    ISSN: 1432-0533
    Keywords: Isotretinoin ; Retinoic acid ; Hydrocephalus ; Teratogen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Isotretinoin, a drug used for the treatment of acne, has been shown to have teratogenic effects. We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts. These findings are related to those reported previously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687018
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Intraventricular neuroblastoma in a patient with Von Hippel-Lindau's disease (1981)
    Springer
    Acta neuropathologica 53 (1981), S. 253-256 
    Details
    ISSN: 1432-0533
    Keywords: Neuroblastoma ; Phakomatosis ; Von Hippel-Lindau's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cerebral neuroblastoma is a rare neoplasm that has not previously been associated with a phakomatosis. We report a case of an intraventricular neuroblastoma in a patient with Von Hippel-Lindau's disease. The neoplasm consisted of process-forming cells containing clear vesicles, dense-cored granules and microtubules. An unusual finding was the presence of intertwining cytoplasmic processes, apparently representing aberrant process formation. We suggest that this case represents a cerebral neuroblastoma occurring as an unusual manifestation of a phakomatosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688029
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructural study of the human neurohypophysis (1980)
    Springer
    Cell & tissue research 205 (1980), S. 273-287 
    Details
    ISSN: 1432-0878
    Keywords: Human neurohypophysis ; Ultrastructure ; Pituicytes ; Ependyma ; Choristoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The pars nervosa of the neurohypophysis from 12 patients undergoing hypophysectomy for palliative treatment of advanced carcinoma was studied electron microscopically. Special attention was given to the cellular elements, the pituicytes. Five different classes of pituicytes, with various transitional forms, were elucidated based on their ultrastructural characteristics: (1) The most common type, referred to as “major pituicytes”, is reminiscent of astrocytes. (2) “Dark pituicytes” are thought to represent different functional stages of the “major pituicytes”. (3) “Ependymal pituicytes” are believed to provide ultrastructural evidence that human pituicytes are phylogenetically derived from ependymal cells. (4) “Oncocytic pituicytes” were observed in all cases and are of unknown significance. (5) The ultrastructural features of “granular pituicytes” suggest the existence of an active uptake and catabolism of extracellular material by pituicytes, probably through “ultraphagocytosis” or “endocytosis”. These five classes of pituicytes are considered to represent different functional forms of one cell line that originates phylogenetically from the ependyma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234685
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Ultrastructural study of the human neurohypophysis (1980)
    Springer
    Cell & tissue research 206 (1980), S. 291-302 
    Details
    ISSN: 1432-0878
    Keywords: Neurohypophysis ; Perivascular space ; Pericytes ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The vascular and perivascular regions of the human neurohypophysis were studied electron microscopically. The abluminal basement membrane, perivascular space, luminal basement membrane and endothelium are interposed between the neural parenchyma and the blood stream. The capillaries are fenestrated, with pores measuring 30 to 50 nm in diameter. The perivascular and intercellular spaces form prominent networks that penetrate between rows of neurohypophysial parenchymal cells. The perivascular space contains pericytes, histiocytes, fibroblasts and mast cells, with ultrastructural features typical of each cell type. No transitional forms between histiocytes and pericytes were observed. A schema for the extracellular flow of neurohypophysial hormones through the sinusoidal and perivascular spaces is proposed, suggesting an important role for the pituicytes and their intercellular junctions in the control of hormone release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00232773
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrastructural study of the human neurohypophysis (1980)
    Springer
    Cell & tissue research 205 (1980), S. 253-271 
    Details
    ISSN: 1432-0878
    Keywords: Neurohypophysis ; Neurosecretory axons ; Neurosecretorygranules ; Ultrastructure ; Man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Neurosecretory axons and their dilatations in the pars nervosa of the human neurohypophysis were studied electron microscopically. The axons are of two different types based on their content of neurosecretory granules (NSGs): (i) NSGs of Type A are 100–300 nm, and (ii) NSGs of type B are 50–100 nm in diameter. While fibers (or axons) of type B were scarce, showing simple swellings and terminal formations, fibers of type A were ubiquitous in the human pars nervosa, exhibiting numerous dilatations with a diversity of internal structure, apparently representing the ultrastructural manifestation of intraaxonal turnover of neurohypophysial hormones. Based on the predominating aspect of their internal structure, dilatations of type A-fibers were classified into six different types, with various transitional forms: Type I is characterized by abundant NSGs; type II by prominent mitochondria; type III by abundant lysosomal bodies; type IV by an electron-lucent matrix with few organelles; type V by prominent tubuloreticular profiles; and type VI by numerous microvesicles. The functional significance of each type is discussed and a scheme of possible interrelationships between these dilatations is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234684
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    Paper (German National Licenses)
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