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  • 1
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 2 (1995), S. 3852-3856 
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Magnetic reconnection in a current sheet with electron gyroradius scale is studied by a full particle simulation, in which the ion-electron mass ratio is set to be mi/me=10−1836. A new dynamo process has been found in which magnetic flux emerges outward from the magnetic O-line in the magnetic island formed by reconnection. The generation of new flux is associated with plasma compression in the magnetic island. The generated new flux is estimated to be ∼B0ρe, independent of the ion-electron mass ratio, where B0 is the magnetic field far away from the current sheet, and ρe is the electron gyroradius based on B0 and the electron thermal velocity. The plasma inertia and momentum transport due to the off-diagonal elements of plasma pressure tensor can lead to E⋅J〈0 near the magnetic O-line, which makes the dynamo process possible. It is also found that the characteristic time scales of the reconnection process have a power-law dependence on the ion-electron mass ratio. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 3843-3845 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We describe the construction of a high voltage electric arc puller for controllable fabrication of bent near-field optical fiber probes. Various probes with bent angles ranging from 30° to 75° and bent lengths between 600 and 900 μm were successfully produced. The tip diameters achieved are between 100 and 200 nm. These bent type probes can be made into cantilevered probes that can be used for any dynamic mode atomic force microscope, and make the construction of a scanning near-field optical microscope easily attainable.© 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 3840-3842 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We present the modification of a commercial tapping mode atomic force microscope into a reflection and transmission dual mode scanning near-field optical microscope. In the configuration, the normal force detection unit is replaced by a shear force detection module and an interfacing circuit. The tip-sample distance control is therefore similar to tapping mode operation. Detection of the near-field signals is based on photodiodes and the lock-in technique, and the resolutions obtained for the topography and the near-field signal are around 80 and 150 nm, respectively.© 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 68 (1997), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Brain capillary endothelial cells are coupled by a continuous belt of complex high-electrical-resistance tight junctions that are largely responsible for the blood-brain barrier. We have investigated mechanisms regulating tight junction permeability in brain endothelial cells cultured to maintain high-resistance junctions. The phospholipid lysophosphatidic acid (LPA) was found to cause a rapid, reversible, and dose-dependent decrease in transcellular electrical resistance in brain endothelial cells. LPA also increased the paracellular flux of sucrose, which, together with the resistance decrease, indicated increased tight junction permeability. Activation of protein kinase C attenuated the effect of LPA, suggesting that it was mediated by activation of a signalling pathway. LPA did not cause any obvious relocalization of adherens junction- or tight junction-associated proteins. However, it did stimulate the formation of stress fibres, the recruitment of focal adhesion components, and the appearance of tyrosine phosphorylated protein at focal contacts. Our study shows that LPA is a modulator of tight junction permeability in brain endothelial cells in culture and raises the possibility that it triggers blood-brain barrier permeability changes under (patho)physiological conditions.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 68 (1997), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Proteases of the interleukin-1β converting enzyme (ICE) family have been implicated as mediators of apoptosis in several cell types. Here we report the ability of peptide inhibitors of ICE-like proteases to inhibit apoptosis of cultured cerebellar granule neurones caused by reduction of extracellular K+ levels and by the broad-spectrum protein kinase inhibitor staurosporine. Unlike apoptosis induced by K+ deprivation, staurosporine-induced neuronal death does not require new protein synthesis. The ICE-like protease inhibitor benzyloxycarbonyl-Val-Ala-Asp (O-methyl)fluoromethyl ketone (zVAD-fmk) was found to be extremely effective at preventing staurosporine-induced death of cerebellar granule neurones and yet was completely ineffective in preventing K+ deprivation-induced death. Staurosporine induced cleavage of the 116-kDa poly(ADP-ribose) polymerase enzyme, a substrate of ICE-like proteases, to the 85-kDa product, and this cleavage was also blocked by zVAD. By comparison, K+ deprivation led to the disappearance of the 116-kDa protein, with no detectable increase in level of the 85-kDa cleavage product. Taken together, these results imply the existence of divergent ICE-like protease pathways in a CNS model of neuronal apoptosis.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 42 (1984), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: An unsaturated fatty acid-binding protein has been isolated from the cytosol fraction of developing chick neural retina. It has a molecular weight of approximately 14,800 and specifically binds not only added radiolabeled arachidonic and oleic acids but has also been found to bind unsaturated fatty acids endogenously. This protein was detected in chick neural retina at all stages examined, from 8 to 16 days of development. It is also present in chick heart, brain, and retinal pigmented epithelium-choroid as well as in adult bovine neural retina. It is distinct from both cellular retinol-binding protein and cellular retinoic acid-binding protein on the bases of binding specificity and isoelectric point.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 13 (1965), S. 309-311 
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 88 (1966), S. 4757-4759 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 4496-4501 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Future 10 Gb/in.2 recording densities represent submicron trackwidths and sub-100 nm bit lengths. This requires extremely small magnetic switching units and very high coercivities of the media to satisfy the signal-to-noise ratio requirements. At the same time the question of magnetic thermal stability and the lack of transducers capable of performing at these densities makes it difficult to evaluate media. An uncoupled, highly uniform magnetic grain size of about 10 nm is a compromise toward maintaining an adequately low media noise and yet maintaining magnetic stability. Here we discuss current media construction, the detrimental role of substrate roughness, the role of new media structures and alloys on microstructure and magnetic properties as well as techniques for evaluating media performance prior to the availability of the required playback heads. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 32 (1967), S. 2012-2013 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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