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  • 1
    Electronic Resource
    Electronic Resource
    Influence of cyclodextrins on nitrosation of drugs (1984)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 2 (1984), S. 605-611 
    Details
    ISSN: 1573-1111
    Keywords: Nitrosation reactions: α-, β-, γ-cyclodextrin, dimethyl-β-cyclodextrin ; piperazine ; ethambutol ; cimetidine ; 1-ephedrine ; fencamfamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The World Health Organization issued a nitrosation procedure (NAP Test) which allows to carry out nitrosation under standard conditions. It has proved that the in vitro reaction rates of the fast nitrosatable drugs piperazine, cimetidine and ethambutol are not influenced by α-, β- and γ-cyclodextrin. On the contrary, β-, γ-cyclodextrin and heptakis-2,6-di-O-methyl-β-cyclodextrin enhance the nitrosation of the slower nitrosatable 1-ephedrine and fencamfamine significantly. This possible reaction must be considered if nitrosatable drugs are formulated with cyclodextrins to be administered to human beings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00662226
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Atomic Force Microscopy Studies of Solid Lipid Nanoparticles (1996)
    Springer
    Pharmaceutical research 13 (1996), S. 1411-1416 
    Details
    ISSN: 1573-904X
    Keywords: atomic force microscopy ; solid lipid nanoparticles ; controlled drug delivery ; prednisolone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. Solid Lipid Nanoparticles (SLN) are an alternative carrier system for the controlled delivery of drugs. In most cases prednisolone loaded SLN show a biphasic release behaviour. The initial phase is characterised by a fast drug release, which is followed by a sustained drug release over several weeks. Methods. The particles are produced by high pressure homogenisation of a lipid (e.g. compritol, cholesterol) dispersed in an aqueous surfactant solution. In this study atomic force microscopy was used to image the original unaltered shape and surface properties of the particles. The crystallinity of the nanoparticles was investigated by differential scanning calorimetry. Results. The AFM investigations revealed the disc like shape of the particles. From differential scanning calorimetry data it can be concluded that the particle core is in the crystalline state. Additionally it was proven that the particles are surrounded by a soft layer. Conclusions. Thus it is conceivable that the fast initial drug release during in vitro dissolution tests takes place by drug release of the outer non-crystalline layers of the particles. The following sustained drug release can be assigned to the predisolone release of the inner crystalline particle layers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016042504830
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Electroproduction of π+ mesons at forward and backward direction in the region of theD 13(1520) andF 15(1688) resonances (1982)
    Springer
    The European physical journal 13 (1982), S. 113-117 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We report on measurements of the reactionep→enπ+ in the region of theD 13(1520) andF 15(1688) resonances. At an invariant four-momentum transferq 2=0.3 (GeV/c)2 the outgoing pion was detected in the forward and backward directions. The values of the helicity-1/2-partial wave amplitudesA 2−(D 13(1520)) andA 3−(F 15(1688)) are determined from these measurements. A comparison of the results with single quark transition models is made.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01547674
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Backward electroproduction of π+ mesons in the second and third nucleon resonance region (1983)
    Springer
    The European physical journal 17 (1983), S. 121-127 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The reactionep→enπ + has been studied in the invariant mass range of 1.44≦W≦1.83 GeV. The outgoing pion was detected in the backward direction (cosλ π * ≦-0.94) with respect to the virtual photon at four-momentum transfers of 0.4≦q 2≦0.7 (GeV/c)2. The values of the helicity-1/2-partial wave amplitudesA 2−(D 13(1520)) andA 3−(F 15(1688)) were determined by a phenomenological analysis and compared with single quark transition models (S.Q.T.M.).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01574177
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Differential supervision and cognitive structure effects on empathy and counseling effectiveness (1981)
    Springer
    International journal for the advancement of counselling 4 (1981), S. 119-129 
    Details
    ISSN: 1573-3246
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Abstract The present study investigated the effects of didactic and experiential supervision procedures on the judged counseling effectiveness of high and low cognitive complexity counselor trainees. Subjects in the two supervision groups (N=16) were trained in attending, questioning, and reflection of feeling over three sessions. Training consisted of exposure to videotaped counseling models, discussion of the model's behavior with the supervisor, videotaped role playing of therapy, and discussion of the therapy with the supervisor. Training was exactly the same for both groups except for supervision. A control group (N=8) did not receive any training. All subjects, including controls, were pre- and post-tested for counseling effectiveness as measured by judged tape ratings on the 25-item Counselor Effectiveness Scale and four scales designed to assess affective, exploratory, listening, and honest labeling responses. High complex subjects responsed more favorably to the didactic supervision significantly outperforming both the high complex controls and the low complex didactic subjects on four of the five dependent measures, whereas high and low complex subjects did not respond differentially to the experiential supervision. The results were discussed in terms of fitting the complexity of the students to the supervision approach in selecting students for counseling programs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00139735
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    Paper (German National Licenses)
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