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  • 1
    ISSN: 1432-1041
    Keywords: Key words Prescription-Event Monitoring ; Cisapride; pharmacovigilance ; adverse drug reactions ; post-marketing surveillance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The results of Prescription-Event Monitoring (PEM) from over 13 000 patients receiving cisapride are compared with safety data from a large-scale clinical study involving nearly 10 000 patients. Results: The clinical study population showed a significantly younger age profile than the PEM population and excluded patients with serious disease; however, both studies showed similar patterns of adverse events. The most common adverse events reported in association with cisapride in both studies were diarrhoea, headache, abdominal pain, constipation and nausea. Some of these may be attributed to the underlying condition rather than the action of the drug. Prompting patients about adverse events during a clinical trial assessment appeared to increase the reporting of some conditions: for example, diarrhoea was reported more frequently in the clinical trial than in the PEM study. Conclusion: Both studies showed cisapride to be generally safe and well tolerated.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To determine the proportion and nature of congenital anomalies in babies born to women exposed to newly marketed drugs during the first trimester.Design Non-interventional observational cohort studies.Methods The women were identified in confidence by the Prescription Pricing Authority. The doctor was sent a questionnaire to determine clinical events, including pregnancy, occurring after the drug was dispensed. A supplementary questionnaire determined the outcome of each reported pregnancy.Setting General medical practice in England.Population Women exposed to newly marketed drugs in whom pregnancy was recorded.Main outcome measures Outcomes of pregnancies, the proportion and nature of congenital anomalies in the babies born.Results 2511 pregnancies were reported. In 831 of these pregnancies a newly marketed drug had been taken during the first trimester and in 74 during the secondkhird trimester. The outcome was ascertained for 780 (94%) of these 831 pregnancies: 547 (66%) births; 10 (1%) ectopic pregnancies; 94 (11%) spontaneous miscarriages; 5 (〈 1%) missed abortions; 120 (14%0) legal abortions; and 4 (C 1%) intrauterine deaths. 557 infants were born, of whom 14 (2.5%) had congenital anomalies.Conclusions The proportion of live infants with a congenital abnormality born to mothers exposed to newly marketed drugs in the first trimester was similar to the percentage of congenital anomalies estimated by the Ofice for National Statistics. These data add valuable information to the safety database of these drugs.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford BSL : Blackwell Science Ltd
    Clinical & experimental allergy 29 (1999), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The post-marketing surveillance (PMS) of drugs is necessary because of the limited size of the clinical safety database at the time of marketing. The principal hypothesis-generating methods of PMS are spontaneous reporting (e.g. the yellow card) and Prescription Event Monitoring. These methods are discussed in this chapter and certain basic pharmacoepidemiological issues that are relevant are briefly reviewed.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 6 (1967), S. 263-266 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 8 (1969), S. 331-333 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 7 (1968), S. 327-335 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report that the ion implantation of a small dose of Mo into a silicon substrate before the deposition of a thin film of Ti lowers the temperature required to form the commercially important low resistivity C54–TiSi2 phase by 100–150 °C. A lesser improvement is obtained with W implantation. In addition, a sharp reduction in the dependence of C54 formation on the geometrical size of the silicided structure is observed. The enhancement in C54 formation observed with the ion implantation of Mo is not explained by ion mixing of the Ti/Si interface or implant-induced damage. Rather, it is attributed to an enhanced nucleation of C54–TiSi2 out of the precursor high resistance C49–TiSi2 phase. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 1 (1969), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of plastic surgery 20 (1997), S. 127-131 
    ISSN: 1435-0130
    Keywords: Electrical burns ; Progressive necrosis ; Delayed bleeding ; Arterial injury ; Pathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study describes the histologic findings of injured arteries after electrical burns. These findings are shown to correlate with the clinical findings of soft tissue necrosis and delayed bleeding. Eight patients with severe electrical injuries who underwent amputations of extremities were studied. Thickening of the tunica intima and degeneration of the tunica media, associated with small artery occlusion, were evident in the arteries at the transition zone between severely injured and grossly normal areas.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Der Orthopäde 25 (1996), S. 302-307 
    ISSN: 1433-0431
    Keywords: Schlüsselwörter Hallux valgus ; Distaler Weichteilrelease ; Proximale metatarsale Osteotomie ; Pathologische Anatomie ; Chirurgische Technik ; Postoperatives Management ; Key words Hallux valgus ; Distal soft tissue procedure with proximal metatarsal osteotomy ; Pathologic anatomy ; Surgical technique ; Postoperative management
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Correction of the hallux valgus deformity is dependent upon recognition of the specific anatomic deformity, followed by selection of a procedure that addresses the specific deformity. A hallux valgus deformity with a subluxated metatarsophalangeal joint has a soft tissue and bony component, both of which need to be corrected, or a recurrence may result. The distal soft tissue procedure addresses the lateral soft tissue contracture by releasing the adductor hallucis, lateral joint capsule and transverse metatarsal ligament. The capsule is medially elongated and the medial eminence needs to be excised. When metatarsus adductus is present, a proximal metatarsal osteotomy should be carried out to correct the bony deformity. If the intermetatarsal angle is not corrected adequately, a recurrence of the hallux valgus is likely since a soft tissue procedure alone could not be expected to correct the bony deformity created by the increased intermetatarsal angle. Postoperatively the correction needs to be supported with a firm compression dressing for 8 weeks to be sure the corrected alignment is maintained until healing of the soft tissues and osteotomy occurs.
    Notes: Zusammenfassung Die Korrektur der Hallux-valgus-Deformität ist abhängig davon, daß die spezifische anatomische Deformität erkannt wird, und daß ein Operationsverfahren gewählt wird, das auf die spezifische Deformität Bezug nimmt. Eine Hallux-valgus-Deformität mit Subluxation im Metatarsophalangealgelenk hat eine Weichteil- und knöcherne Komponente und wenn nicht beide korrigiert werden, ist mit einem Rezidiv zu rechnen. Der distale Weichteileingriff korrigiert die laterale Weichteilkontraktur durch Release des M. adductor hallucis, der lateralen Gelenkkapsel und des Lig. intermetatarsale transversum. Die mediale Kapsel ist ausgeweitet und die mediale Pseudoexostose muß abgetragen werden. Bei einem Metatarsus abductus (Metatarsus primus varus) ist eine proximale metatarsale Osteotomie notwendig, um die knöcherne Deformität zu korrigieren. Wenn der Intermetatarsalwinkel nicht ausreichend korrigiert wird, ist ein Rezidiv des Hallux valgus wahrscheinlich, da der Weichteileingriff allein die knöcherne Deformität, die durch den erhöhten Intermetatarsalwinkel verursacht ist, nicht korrigieren kann. Postoperativ muß die Korrektur mit einem festen Kompressionsverband für 8 Wochen in Korrekturstellung fixiert werden, um sicherzustellen, daß die korrigierte Stellung so lange gehalten wird, bis die knöcherne und Weichteilheilung eingetreten ist.
    Type of Medium: Electronic Resource
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