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  • 1
    Digitale Medien
    Digitale Medien
    A new type of multiparticle imaging detector (1990)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 61 (1990), S. 945-952 
    Details
    ISSN: 1089-7623
    Quelle: AIP Digital Archive
    Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: The foil-induced dissociation of molecular ions can provide a direct image of the stereochemical structures of small molecules. Such experiments require high-resolution measurements of the relative momenta of all dissociation fragments. In order to improve and extend previous studies of this type to a larger variety of molecules and clusters, we have developed a new type of low-pressure multiwire proportional counter. The novel feature of this large-area (25×50 cm2 ) multiparticle detector is that all the signals are recorded from a single two-level printed circuit board which serves as the anode. This segmented anode consists of three families of nonintersecting "wires'' which are interwoven on the rear surface of the board. By redundantly determining positions and arrival times, the new segmented anode multiparticle detector provides good time resolution (100–200 ps) and high spatial resolution (0.2 mm) for detecting as many as six simultaneous particles.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1141447
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  • 2
    Digitale Medien
    Digitale Medien
    Neutrophils, leukotrienes and bacteria (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 21 (1991), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.1991.tb01707.x
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  • 3
    Digitale Medien
    Digitale Medien
    G-proteins in allergy (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 27 (1997), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.1997.tb02576.x
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  • 4
    Digitale Medien
    Digitale Medien
    Cetirizine counter-regulates interleukin-8 release from human epithelial cells (A549) (1999)
    Oxford BSL : Blackwell Science Ltd
    Clinical & experimental allergy 29 (1999), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Cetirizine, a H1-receptor antagonist, exerts besides its well-known anti-allergic potential an array of anti-inflammatory activities. In particular epithelial cells activated in the presence of cetirizine showed a reduced ICAM-1 cell surface expression and a diminished release of sICAM-1.〈section xml:id="abs1-2"〉〈title type="main"〉ObjectiveWe wondered whether cetirizine might influence the release of interleukin-8 (IL-8) from human epithelial cells activated with agonists distinct from histamine.〈section xml:id="abs1-3"〉〈title type="main"〉MethodsWe used the human lung epithelial cell line A549 for our in vitro studies. IL-8 release was determined by IL-8 enzyme immunoassay, the intracellular staining for IL-8 and NF-kB was analysed by FACS analysis and IL-8 mRNA steady state level was studied by Northern blot analysis. Confluent epithelial cell monolayer were pre-incubated with cetirizine (0.01 −1.0 μmol/L) for 30 min and afterwards activated with pro-inflammatory cytokines (TNF-α IL-1β, IL-6, IFN-γ) or different agonists (PMA, NaF, respiratory syncytial virus [RSV]) for 24 h.〈section xml:id="abs1-4"〉〈title type="main"〉ResultsEpithelial cells stimulated with TNF-α IL-1β, PMA and RSV, respectively, showed a significantly increased release of IL-8. Pre-incubation with cetirizine diminished the IL-8 release from cells activated with TNF-α or PMA in a significant manner. The reduced IL-8 release coincided with a diminished percentage of cells expressing IL-8. Northern blot analysis revealed a reduced steady state level of IL-8 mRNA in cells pretreated with cetirizine and stimulated with TNF-α. Furthermore, a decreased amount of accessible DNA-binding sites of the nuclear factor kappa B (NF-kB) was determined by FACS analysis.〈section xml:id="abs1-5"〉〈title type="main"〉ConclusionsThese results suggest that cetirizine reduced the release of IL-8 from A549 cells stimulated with PMA and TNF-α, respectively, by lowering IL-8 gene expression. Therefore, cetirizine might exert anti-inflammatory effects beyond its H1-receptor antagonistic activity in the course of inflammatory respiratory tract disorders such as bronchial asthma and allergic rhinitis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2222.1999.00630.x
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  • 5
    Digitale Medien
    Digitale Medien
    Propolis allergy (IV) Studies with further sensitizers from propolis and constituents common to propolis, poplar buds and balsam of Peru (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 26 (1992), S. 0 
    Details
    ISSN: 1600-0536
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 26 different compounds have been investigated experimentally for their sensitizing capacity in guinea pigs. 19 of these occur in propolis as well as in poplar bud exudates, and 14 of them are also found in balsam of Peru. 4 caffeates and benzyl isoferulate were found to be strong Sensitizers. 7 compounds were moderate, and 13 compounds showed only weak sensitizing potency. Methyl cinnamate was negative. Patch tests in 11 propolis-sensitive patients once more revealed 3-methyi-2-butenyl caffeate and phenylethyl caffeate as the major sensitizers. In addition to the 8 compounds already known to occur in propolis as well as in balsam of Peru, we detected 5 further substances that both materials have in common. Among these, benzyl isoferulate is considered a noteworthy sensitizer. Coniferyl benzoate, which was shown to be a moderate sensitizer, is present in fresh samples of balsam of Peru, while in propolis it has been detected only once so far. The flavonoid aglycones occurring in poplar bud exudates, and hence also in propolis, are weak sensitizers which play only a minor role m propolis hypersensitivity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0536.1992.tb00865.x
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  • 6
    Digitale Medien
    Digitale Medien
    The allergens of nail polish (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 33 (1995), S. 0 
    Details
    ISSN: 1600-0536
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Nail polish that has completely dried on the fingernails contains water-soluble components that attain the skin during extensive but transient contact. This was proven by water extraction of thin layers of nail polish that had been painted onto glass plates and allowed to dry for 3 days. Comparing the isolated fractions and compounds with known nail polish ingredients revealed that the water-soluble substances are para- and ortho-toluenesulfonamide. Dihuty1 phthalate and 3 constituents of toluenesulfonamide-formaldehyde resin (TS-F-R), which is the basic material of almost all nail polishes sold worldwide. 12 female patients with proven nail polish allergy were patch tested with 21 nail polish components, including those isolated. Only 2 fractions were positive. These contained a monomer and a dimer created during condensation of TS-F-R. Their structures were elucidated. The 3rd compound, a trimer, remained negative, except in 1 case.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0536.1995.tb00537.x
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  • 7
    Digitale Medien
    Digitale Medien
    Structure-activity relationships in allergic contact dermatitis (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 33 (1995), S. 0 
    Details
    ISSN: 1600-0536
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Primin (2-methoxy-6-pentyl-1,4-benzoquinone)is a naturally-occurring strong sensitizer from Primula obconica (Primulaceae), To determine the effect of side-chain length on senstizing potency 15 analogues with linear side chains from to from C1, to C15 and 4 C6- analogues with branched side chains were prepared synthetically and devoted to experimental sensitization in guinea pigs The results showed an increase of the sensitizing capacity with increasing length of the alkyl side chain from C1 to C10, reaching a maximum at C11 and C12. On further elongation the senstizing potency decreased beyond C13 reaching values which finally were as low as those of the C1 and C3 derivatives. The results mirror finding which finally were as low as those of the C1 and C3 derivatives. The results mirror findings which formerly have been obtained with other non-quinonoid compounds like catechols, phenols hydroquinones and gallates. In the plant kingdom. Compound approximating an “ideal allergen” consisting of a quinonoid ring with a 10 or 11 carbon-remarkably strong sensitizer found in Wigandia caracasana (Hydrophyllaceae)
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0536.1995.tb00440.x
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  • 8
    Digitale Medien
    Digitale Medien
    New hydroxyisoflavans as contact sensitizers in cocus wood Brya ebenus DC (Fabaceae) (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 25 (1991), S. 0 
    Details
    ISSN: 1600-0536
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: A 15-year-old girl developed perioral dermatitis and swelling of the lips, having played a flute made of cocus wood for 2 years. Patch tests with wood shavings, as well as with subsequently isolated constituents named focus 1 and focus II. were Strongly positive. Alter complete purification, boltContact allergens were identified as isoflavan derivatives, While Cocus 1 was shown to be 7,8-dihydroxy-2,4,5trmethoxyisoflava, the structure of focus II could not be elucidated exactly. It could have been Either 7,8,3′-trihydroxy 2,4 dimethoxyisoflavan or 7,8,2-trihydroxy-3′,4-dime-thoxyoflavan The exact position of the hydroxy and methoxy group in C-2 and C-3 can be determined only by complete synthesis Of both compounds or by isolation of greater amounts of focus II for further oxidation experiments. Due t0 the stronger patch lest reaction and the higher yield cocus I in the wood, this hydroxyisoflavan must be recognized as the main contact allergen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0536.1991.tb01820.x
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  • 9
    Digitale Medien
    Digitale Medien
    Die Umkehrung des Euler-Knoppschen und des Borelschen Limitierungsverfahrens auf Grund einer Lückenbedingung (1943)
    Springer
    Mathematische Zeitschrift 49 (1943), S. 151-160 
    Details
    ISSN: 1432-1823
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01174195
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  • 10
    Digitale Medien
    Digitale Medien
    Neurological outcome after a severe herpes simplex encephalitis treated with acyclovir and β-interferon time course of intracranial pressure (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 286-289 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Herpes-Simplex encephalitis ; Intracranial pressure monitoring
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A severe herpes simplex encephalitis with documented intra-cerebral lesions and brain edema was treated successfully with acyclovir andβ-interferon. The increase in intracranial pressure during the second week was well controlled by ICP monitoring. Life-threatening pressure peaks were avoided through the use of thiopental, osmodiuretics, TRIS, and lidocaine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02116059
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