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  • 1
    Digitale Medien
    Digitale Medien
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 4 (1997), S. 3394-3402 
    ISSN: 1089-7674
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: The theory of the inverted gyrotwystron, a gyrodevice consisting of the input waveguide and output cavity separated by the drift section, is developed. The case of frequency doubling when the input waveguide operates at the fundamental cyclotron resonance and the output cavity operates at the second cyclotron harmonic is analyzed. It is shown that the electron prebunching in the input waveguide provides a better harmonic content in the electron current density than a standard ballistic bunching occurring in gyroklystrons with a short input cavity followed by a long drift section. The dependence of the efficiency and locking bandwidth on the input power and the lengths of input waveguide and drift section is studied. The effect of the electron velocity spread on the locking bandwidth and the electronic efficiency is analyzed. © 1997 American Institute of Physics.
    Materialart: Digitale Medien
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Plant pathology 48 (1999), S. 0 
    ISSN: 1365-3059
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Experiments were conducted over two seasons (1995 and 1996) to determine the survival of Botrytis cinerea conidia applied to the fruit surface of kiwifruit (Actinidia deliciosa, cv. Hayward). In 1995, potted vines were exposed for nine weeks to controlled environments at the National Climate Laboratory and to natural conditions in a shadehouse. In 1996, field experiments were carried out over a period of 16 weeks at two research sites. Change in number of conidia (enumeration), viability (germination) and vigour (germ-tube length, 1995; infection of host tissue, 1996) of conidia were assessed over time. In both years, the number of conidia/fruit declined significantly over time. However, conidia remained viable on the fruit surface throughout the two experiments. In both seasons, approximately 40% of the conidia recovered still germinated after field exposure and the vigour of viable conidia remained constant over the duration of the two experiments. The results of the research showed that B. cinerea conidia are able to survive on fruit surfaces of kiwifruit, remaining viable and infectious throughout the growing season.
    Materialart: Digitale Medien
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  • 3
    Digitale Medien
    Digitale Medien
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Ecology, Evolution, and Systematics 30 (1999), S. 397-420 
    ISSN: 0066-4162
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Biologie
    Notizen: Abstract The search for the origins of life and its presence beyond Earth is strengthened by new technology and by evidence that life tolerates extreme conditions and that planets are widespread. Astrobiologists learn how planets develop and maintain habitable conditions. They combine biological and information sciences to decipher the origins of life. They examine how biota, particularly microorganisms, evolve, at scales from the molecular to the biosphere level, including interactions with long-term planetary changes. Astrobiologists learn how to recognize the morphological, chemical, and spectroscopic signatures of life in order to explore both extraterrestrial samples and electromagnetic spectra reflected from extrasolar planets.
    Materialart: Digitale Medien
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  • 4
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 26 (1999), S. 0 
    ISSN: 1365-2842
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: In a randomized clinical study 47 titanium and gold-alloy fixed partial dentures (FPDs) were placed during a 1-year period. In the titanium group (n=22) all metal substructures were made of unalloyed titanium. The titanium substructures were fabricated by copy milling, spark erosion and laser welding (Procera®, Nobelpharma). Ceramic veneering was carried out with Duceratin® titanium ceramics (Ducera, Germany). In the control group (n=25) the high-gold alloy Degudent U® (Degussa, Germany) and Vita VMK 68® ceramics (Vita, Germany) were used. The longest observation time was 6 years. Only one FPD had to be removed due to metal–ceramic failure (titanium group). The clinical performance of all 125 porcelain-fused-to-metal (PFM) veneers with respect to the longevity of the metal–ceramic compound was described by Kaplan–Meyer survivor analyses. Relating survival to a completely intact ceramic veneer, the 5-year survivor rate was 84% for titanium and 98% for the high-gold alloy. PFM titanium restorations exhibited a significantly increased risk of metal–ceramic failure. However, concerning defects requiring removal, no significant differences in titanium versus high-gold alloy occurred. There were no significant differences in the survival distributions between crowns and pontics within the two groups.
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 51 (1996), S. 0 
    ISSN: 1398-9995
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: B-cell epitopes of bovine αs1-casein, one of the major allergens of cow's milk, were identified by a screening method based on synthetic peptides. According to the known amino acid sequence of αs1-casein, a set of 188 overlapping sequential decapeptides shifted by one amino acid was manually synthesized on polyethylene pins by the 9-fluorenyl-methoxycarbonyl (Fmoc) method. Peptides were screened by an enzyme-linked immunosorbent assay (ELISA) specific for human IgE and IgG. Bound antibodies were detected by successive incubation with up to three polyclonal antibodies, the last one conjugated to horseradish peroxidase. Tested sera were from 15 patients with acute clinical reactions to cow's milk and IgE-specific reactions to bovine a-casein in the ELISA and immunoblot. Sera from 10 healthy subjects without remarkable reactions to cow's milk proteins were used as controls. All sera from allergic subjects showed reactions with three regions of αs1-casein, corresponding to amino acids 19–30, 93–98, and 141–150. Furthermore, individual sera showed reactions with other parts of the protein. No essential differences in the epitope specificity of IgE and 1gG were found. Inhibition of IgE binding to αs1-casein with soluble synthetic peptides confirmed the results and revealed peptide CN-2 as the most inhibiting one.
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 52 (1997), S. 0 
    ISSN: 1398-9995
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The allergic potential of α-caseins from bovine, ovine, and goat's milk sharing more than 85% identical amino acids was compared. Caseins were purified by anion-exchange chromatography and used for a specific IgE and IgG ELISA with diluted human sera. Sera were from 17 children with immediate-type allergy to cow's milk, from 59 children with atopy but without food allergy, and from 27 healthy children without atopic disease. The sera of cow's milk-allergic children showed a significantly higher IgE and IgG binding to α-caseins from all three species than the sera of the other groups. All groups showed an increased antibody binding to bovine a-casein compared to the sheep and goat proteins, but the differences were significant only in the groups of atopic children and of healthy controls. Furthermore, inhibition of the IgE binding to bovine α-casein with α-casein from cow, goat, and sheep revealed that the a-caseins from these species are highly cross-reactive, on the basis of the small differences in their primary structure. In conclusion, the milk of goat and sheep harbor an allergic potential and is not suitable for the nutrition of milk-allergic patients.
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Journal of molecular evolution 44 (1997), S. S065 
    ISSN: 1432-1432
    Schlagwort(e): Key words: Phylogeny — Parsimony — Networks — Viruses
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract. In studying population data, it is common to have many equally possible parsimonious trees. This has caused representational problems, all of which have been addressed by using various kinds of consensus trees. Recognizing that the incubus may in fact be the constraint of having to have a tree representation, several authors have investigated networks as a better form. In this paper, a beginning to a new procedure for making most parsimonious networks is developed. The algorithm, as developed so far, is presented. Its applicability to several viral evolutionary problems is illustrated and the nature of the problems needing yet to be addressed are discussed.
    Materialart: Digitale Medien
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  • 8
    ISSN: 1399-0047
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Notizen: A diffraction geometry utilizing convergent X-rays from a polycapillary optic incident on a stationary crystal is described. A mathematical simulation of the resulting diffraction pattern (in terms of spot shape, position and intensity) is presented along with preliminary experimental results recorded from a lysozyme crystal. The effective source coverage factor is introduced to bring the reflection intensities onto the same scale. The feasibility of its application to macromolecular crystal data collection is discussed.
    Materialart: Digitale Medien
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  • 9
    ISSN: 1662-9752
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Materialart: Digitale Medien
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Cancer chemotherapy and pharmacology 44 (1999), S. 81-87 
    ISSN: 1432-0843
    Schlagwort(e): Key words Cyclin-dependent kinase ; Cytotoxicity ; Apoptosis ; Multidrug resistance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Purpose: To determine the in vitro effects of flavopiridol on bladder cancer cell lines, immortalized urothelial cell lines, and normal urothelial cells well characterized for defects in p53, pRb, and p16. Methods: Growth inhibition was assessed via an MTT assay and apoptosis via DAPI nuclear staining. Cell cycle analysis was performed via propidium iodide staining and fluorescent activated cell sorting (FACS). Multidrug-resistant cells were generated by continuous exposure to doxorubicin. Results: Growth inhibition was not correlated with inactivation of p53, pRb, or p16. All cells experienced G2/M arrest within 24 h of flavopiridol exposure. Modest apoptosis was observed but required 72 h of continuous drug exposure to become evident. There was no obvious synergistic or antagonistic toxicity when flavopiridol was combined with radiotherapy or cisplatin dosed at the IC50 despite the observation that radiotherapy and flavopiridol led to more profound G2/M arrest than either agent alone. Doxorubicin-resistant cells, demonstrated to overexpress the MDR1 multidrug-resistance protein were equally as sensitive to flavopiridol as the parental cells. Conclusions: Flavopiridol is a novel cell cycle inhibitor that may be a useful agent in bladder cancers with tumor suppressor gene alterations and/or multidrug resistance.
    Materialart: Digitale Medien
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