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  • 1
    Electronic Resource
    Electronic Resource
    Increased serum urate in galactosemia patients after a galactose load: A possible role of nucleotide deficiency in galactosemic liver injury (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 1169-1170 
    Details
    ISSN: 1432-1440
    Keywords: Galaktose ; Galaktosämie ; Harnsäure im Serum ; Nucleotidmangel ; Leberschädigung ; Galactose ; Galactosemia ; Urate in serum ; Nucleotide deficiency ; Liver injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Five galactosemic and 5 normal children received an oral load of galactose under standardized conditions. The maximal blood galactose level after 1.5 hours was 12.6±2.0 (S.D.) mmol/l in individuals with a deficiency of uridylyl transferase (EC2.7.7.12) as compared to 5.8±1.2 (S.D.) mmol/l in the controls. The concentration of serum urate in galactosemics increased to 155% of the fasting level (P〈0.005); no rise was detectable in the controls. The elimination of urate with the urine was augmented by the same amount in both groups. Our studies provide evidence for an increased catabolism of hepatic nucleotides. This may lead to a deficiency of nucleotides which is proposed as a cause of galactosemic liver injury.
    Notes: Zusammenfassung Fünf galaktosämische und 5 normale Kinder wurden unter standardisierten Bedingungen oral mit Galaktose belastet. Nach 1,5 Std wurde bei Kindern mit inaktiver Uridylyltransferase (EC2.7.7.12) ein maximaler Galaktosegehalt im Vollblut von 12,6±2,0 (S.D.) mmol/l erreicht; der entsprechende Wert bei den Kontrollkindern betrug 5,8±1,2 (S.D.) mmol/l. Die Harnsäurekonzentration im Serum der Galaktosämiker stieg dabei auf 155% der Ausgangswerte an (P〈0.005); ein Anstieg bei den Kontrollkindern blieb aus. Die Harnsäureausscheidung im Urin war bei beiden Gruppen in gleichem Ausmaß erhöht. Die Befunde sprechen für einen vermehrten Nucleotidabbau in der galaktosämischen Leber unter Galaktosebelastung; ein Nucleotidmangel wird als Ursache der galaktosämischen Leberschädigung diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476458
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  • 2
    Electronic Resource
    Electronic Resource
    Immunological studies on bee-keepers: Specific IgG and subclass typing IgG against bee venom and bee venom components (1980)
    Springer
    Journal of molecular medicine 58 (1980), S. 1257-1260 
    Details
    ISSN: 1432-1440
    Keywords: Bienengift-spezifisches IgG ; Subklassen IgG 1–4 Antikörper ; Allergie ; Schutz bei Imkern ; Bee venom specific IgG ; Subclass IgG 1–4 antibodies ; Allergy ; Protective effect in bee-keepers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Specific IgE antibodies against bee venom and its components were studied in 23 bee-keepers. The highest IgG serum levels were observed for whole bee venom followed by phospholipase A. The serum levels of specific IgG antibodies against melittin and MCD-peptide were lower, the lowest serum levels being observed for apamin. After a 5 month absence from bee-keeping a fall in the serum levels of IgG antibodies was observed in all the bee-keepers studied. The investigation of the IgG subclass antibodies 1–4 against bee venom and phospholipase A demonstrated the highest serum levels for IgG 4 and IgG 2, the lowest levels were observed for IgG 1. The lowest IgG serum levels were associated with the least effective protection to bee stings. These findings support the concept that specific IgG antibodies prevent the development of allergic symptoms after bee sting.
    Notes: Zusammenfassung Spezifische IgG-Antikörper gegen Bienengift und Bienengift-Bestandteile wurden im Serum von 23 Imkern bestimmt. Die höchsten Titer wurden gegen das Gesamt-Bienengift gefunden, jeweils geringere gegen Phospholipase A, Melittin, MCD-Peptid und Apamin. Bei Messung der spezifischen IgG-Antikörper der Subklassen 1–4 gegen Gesamt-Bienengift und Phospholipase A wurden die höchsten Titer in den Subklassen 4 und 2, die niedrigsten in der Subklasse 1 gefunden. Nach 5 Monaten ohne Bienenstiche wiesen alle untersuchten Imker einen Antikörper-Abfall auf. Die klinisch stärkste Reaktion auf Bienenstiche zeigten Imker mit den niedrigsten spezifischen IgG-Spiegeln. Diese Untersuchungen zeigen, daß spezifische IgG-Antikörper eine wichtige Rolle bei der Verhinderung von allergischen Symptomen nach Bienenstich spielen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478932
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  • 3
    Electronic Resource
    Electronic Resource
    Micro-enzyme-linked immunoassay for the quantitation of platelet-associated IgG (PAIgG) (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 165-167 
    Details
    ISSN: 1432-1440
    Keywords: Platelet-associated IgG ; Micro-enzyme-linked immunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An enzyme linked immunoassay was developed using the microtiter system to measure platelet-associated IgG (PAIgG). One single determination needs 2×106 platelets usually obtained from 3 ml blood anticoagulated with EDTA. Platelets are incubated with peroxidase-conjugated anti-human IgG. Its unbound fraction is adsorbed to an IgG coated microtiter plate, quantitated by a colour reaction and found to be inversely related to the amount of PAIgG. Healthy donors (n=40, aged 1 day to 35 years) possessed 3.6±2.0 (mean±S.D.) fg IgG/platelet. Increased levels of PAIgG were found in patients with acute (n=16) and chronic (n=5) idiopathic thrombocytopenic purpura. Postrecovery platelets had normal values of PAIgG. Widely varying levels of PAIgG were found in patients with freshly diagnosed acute lymphocytic leukemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486372
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  • 4
    Electronic Resource
    Electronic Resource
    Enzyme-linked immunosorbent assay of allergen-specific IgG antibodies in bee sting allergic patients hyposensitized with pure bee venom (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 421-422 
    Details
    ISSN: 1432-1440
    Keywords: Enzym-Immun-Test ; IgG-Antikörper ; Bienenstich-Allergie ; reines Bienengift ; Schnell-Hyposensibilisierung ; ELISA ; IgG antibody ; Bee sting allergy ; Pure bee venom ; Rapid hyposensitization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary An ELISA is presented for detection of IgG antibodies to bee venom. By this method, sera of 11 bee sting allergic patients, who were treated with rapid hyposensitization with pure bee venom, were tested. The highest antibody titers were observed after 30 days of treatment, a maximum rise of 7.4±1.5 log 2-titer steps. Pure bee venom is shown to be more potent immunologically than whole body bee extract. Prediction of the clinical success, measured by tolerance to a bee sting challenge, is not yet possible using venom specific IgG determinations.
    Notes: Zusammenfassung Es wird ein Enzym-Immun-Test zur Bestimmung von IgG-Antikörpern gegen Bienengift vorgestellt. Mit dieser Methode wurden Seren von 11 Bienenstich-Allergikern untersucht, bei denen eine Schnell-Hyposensibilisierung mit reinem Bienengift durchgeführt wurde. Die höchsten Antikörper-Titer wurden 30 Tage nach Behandlungsbeginn beobachtet, ein maximaler Anstieg um 7,4±1,5 log 2-Titerstufen. Die Immunogenität des reinen Bienengiftes ist höher als die des Ganzkörperextraktes, mit dem einige Patienten vorbehandelt waren, gemessen jeweils an der Menge der gebildeten IgG-Antikörper. Eine Voraussage über den klinischen Erfolg der Hyposensibilisierung (Bienenstich-Exposition) ist gestützt allein auf die IgG-Aantikörper-Titer derzeit noch nicht möglich.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01480482
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  • 5
    Electronic Resource
    Electronic Resource
    The essential amino-acid requirements of the prawnPalaemon serratus. The growth of prawns on diets containing proteins of different amino-acid compositions (1971)
    Springer
    Marine biology 10 (1971), S. 77-81 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Two specimens ofPalaemon serratus Pennant (of about 4 g wet weight) were each given intrahaemocoelic injections of [U-14C] acetate. They were maintained under controlled conditions, and the release of14CO2 and other labelled metabolites was followed for 6 days. The prawns were then sacrificed and fractionated into trichloroacetic acid soluble compounds, lipids, nucleic acids and a protein/chitin residue. Little or no14C had been incorporated into arginine, methionine, valine, threonine, isoleucine, leucine, lysine, histidine, phenylalanine and tryptophan. It was inferred thatP. serratus cannot synthesize these amino acids from ordinarily available materials, and that the prawns have an absolute dietary requirement for them. The glucosamine isolated from the protein/chitin residue contained more radioactivity than any of the other compounds examined. This implies a rapid turnover of glucosamine and chitin inP. serratus. The gain in weight of prawns fed on compound diets containing freeze-dried cod muscle was about 70% that of prawns fed on fresh mussel mantle. Predigestion of freeze-dried cod muscle with proteolytic enzymes did not significantly enhance its nutritional valve as assessed by increases in weight. Prawns fed two other compounded diets containing proteins of low nutritional value (gelatin and zein, respectively) grew at about 1/5 the rate of prawns fed fresh mussel mantle. Supplementation of the gelatin and zein in these diets with tryptophan, and with lysine plus tryptophan, respectively, failed to augment their nutritional value significantly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02026769
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  • 6
    Electronic Resource
    Electronic Resource
    Rubella vaccination (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 570-573 
    Details
    ISSN: 1432-1076
    Keywords: Rubella virus ; Congenital infection ; Vaccination ; Eradication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rubella vaccination programmes aim to prevent congenital rubella infections. Previously differing programmes have now converged according to the following principle: First vaccination should be given at the age of 15 months (together with measles and mumps vaccine) to both boys and girls, in order to diminish the circulation of the wild virus. Teenage girls require (re-)vaccination to ensure their immunity. Also non-immune women have to be identified and vaccinated before they become pregnant. A low acceptance rate increases the risk of infection of pregnant women, independent of the vaccination omitted. As a rule natural and vaccine-induced immunity prevents congenital rubella infections. These infections are exceedingly rare in children born to immune mothers, and are always caused by the wild virus. This minimal risk will disappear only with the eradication of rubella virus, still a distant goal in countries offering vaccination only on a voluntary basis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442464
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  • 7
    Electronic Resource
    Electronic Resource
    The prognostic significance of specific IgG antibodies in insect sting allergy (1981)
    Springer
    European journal of pediatrics 136 (1981), S. 31-34 
    Details
    ISSN: 1432-1076
    Keywords: Specific IgG antibodies ; IgG-subclasstyping ; Bee-sting allergy ; Hyposensitization ; bee keepers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Specific IgG antibodies against bee venom and bee venom components were studied in the serum of 40 bee-sting allergic patients, 60 bee keepers, and 31 control subjects. The highest titres were observed in successfully hypothesized patients and in bee keepers. Subclass-typing in bee-sting allergic patients showed the highest antibody levels in subclass IgG 2, followed by IgG 3, IgG 4 and IgG 1. During hyposensitization, a rise in specific IgG antibodies in all subclasses and against bee venom and all its components was found. The allergic reaction to bee stings disappeared with the rise of specific IgG antibodies, as demonstrated by a bee-sting challenge. After 6 months of hyposensitization therapy, the specific IgG antibodies remained above, and the specific IgE antibodies fell below, the pretreatment levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441707
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  • 8
    Electronic Resource
    Electronic Resource
    Characterization of antigens and allergens in hypo-allergenic infant formulae (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 289-294 
    Details
    ISSN: 1432-1076
    Keywords: Key words Hypo-allergenic infant formula ; Allergen ; Antigen ; Immunoblotting ; RAST
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The antigenicity and allergenicity of so-called hypo-allergenic infant formulae is mainly determined by the degree of hydrolysis and ultra-filtration. Five different formulae were investigated by means of immunoblotting and RAST in order to characterize the antigens and allergens regarding their molecular weights, molecular origin and their ability to bind human IgG and IgE antibodies: A non hydrolysed infant formula (I-F), a mixture of the major cow's milk proteins (PM), a whey-based infant formula (W-H), a whey-based and ultra-filtrated infant formula (U-H), a casein/whey-based infant formula (CW-H). By immunoblotting we demonstrated that all tested formulae still contain antigens with molecular weights from 3 to 67 kD. But when compared with I-F and PM the antigen content of the hydrolysed formulae was considerably lower. The lowest antigen content could be demonstrated in U-H, which contains casein fragments (3–6 kD) and beta-lactoglobulin and its fragments (6–18 kD). W-H and CW-H contain bovine serum albumin, beta-lactoglobulin, casein and their fragments (3–67 kD). All hydrolysed formulae tested showed a reduced IgE-binding capacity. Three out of 12 cow's milk allergic children possessed IgE binding to U-H or W-H, and 5 of them IgE against CW-H. Conclusion The enzymatic hydrolysis plus ultra-filtration seems to be the most efficient method to reduce the antigen content of so-called hypo-allergenic infant formuale.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957364
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  • 9
    Electronic Resource
    Electronic Resource
    Prospektive Studie zur JCR-Oligo I der Arbeitsgemeinschaft Kinder- und Jugendrheumatologie (2000)
    Springer
    Zeitschrift für Rheumatologie 59 (2000), S. 122-123 
    Details
    ISSN: 0340-1855
    Keywords: Schlüsselwörter Juvenile chronische Arthritis –¶Oligoarthritis Typ I –¶intraartikuläre Steroidinjektion – nichtsteroidale antiinflammatorische Therapie – randomisierte klinische Studie ; Key words Juvenile rheumatoid arthritis – oligoarthritis type I –¶intra-articular corticosterid injection – non steroidal anti-inflammatory drugs – randomized clinical trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Intra-articular injection of corticosteroids is a powerful anti-inflammatory treatment with relatively few side effects. To date no prospective RCT exists on its use in children with oligoarthritis type I. Thus, in January 2000 the Arbeitsgemeinschaft started a multicenter RCT to compare in children with this diagnosis the initial treatment recommended in the textbooks, which is NSAID plus physiotherapy, with the early use of intra-articular injection of Triamcinolonhexacetonite. In the synovial fluid the presence of cytokines and the specific reactivity of T cells will be explored, and a highly sensitive screening for infectious agents will be performed.
    Notes: Zusammenfassung Die intraartikuläre Steroidinstallation ist ein rasch wirksames lokal-antiinflammatorisches Behandlungskonzept und hat in geübten Händen wenig Nebenwirkungen. Es gibt jedoch keine prospektive vergleichende Studie zur Anwendung bei Patienten mit Oligoarthritis Typ I. Die Arbeitsgemeinschaft für Kinder- und Jugendrheumatologie wird daher am 1. Januar 2000 eine multizentrische kontrollierte Studie beginnen, die bei Kindern unter 8 Jahren die derzeitige „Lehrbuch-Therapie” (nicht steroidale antiinflammatorische Therapie plus Physiotherapie) mit frühzeitiger intraartikulärer Injektion von Triamzinolonhexacetonit plus Physiotherapie verglichen werden soll. Begleitforschung findet an der Synovialflüssigkeit (lokale Zytokinproduktion, spezifische Reaktivität der T-Zellen und Erregersuche mit empfindlichsten Methoden (PCR)) statt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003930050216
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  • 10
    Electronic Resource
    Electronic Resource
    Empfehlungen der Arbeitsgemeinschaft Kinder- und Jugendrheumatologie zur Therapie mit Etanercept (P75 TNF-α-Rezeptor- Immunglobulinfusionsprotein) (2000)
    Springer
    Zeitschrift für Rheumatologie 59 (2000), S. 365-369 
    Details
    ISSN: 0340-1855
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003930070043
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