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  • 1995-1999  (2)
  • Key words: Vøring Basin, crustal structure, 3-component OBSs.  (1)
  • Key words 5-Fluorouracil  (1)
Materialart
Erscheinungszeitraum
  • 1995-1999  (2)
Jahr
  • 1
    ISSN: 1420-9136
    Schlagwort(e): Key words: Vøring Basin, crustal structure, 3-component OBSs.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Physik
    Notizen: Abstract —Semi-regional Ocean Bottom Seismograph (OBS) data acquired in the central and northern part of the Vøring Basin, mid-Norway margin, have been modeled by use of 2-D ray-tracing. The semi-regional model, derived from the study of twenty-five OBSs deployed along a 120-km long profile, is compared with a regional model consisting of five OBSs from the same profile. The semi-regional model is somewhat more detailed than the regional model, due to the considerably closer receiver spacing. The overall geometry and velocity distribution of the two models are remarkably similar, however, proving that the regional procedure with large OBS spacing provides a reliable regional model.¶Intrusions of sills, related to early Tertiary continental rifting and break up, are important at intermediate and deep sedimentary levels (2–10 km below sea floor) in most parts of the area. The semi-regional modeling suggests that one of the deepest sills extends much further east and is substantially thicker (locally more than 500 m) than indicated in the regional model. Another important difference is a high-velocity body within the upper crystalline crust at 11–12 km depth in the NW part of the area, indicating that the closer OBS spacing in the semi-regional modeling allows detection of local intra-crustal intrusions. Local differences are also inferred in the lower crust; at about 20 km depth a structure is inferred within the lower crust from wide-angle reflections. This might suggest that the high-velocity lower crustal layer, interpreted as magmatic underplating, consists of a mixture of underplated/intruded magmatic material and blocks of continental lower crust.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-1041
    Schlagwort(e): Key words 5-Fluorouracil ; Hair analysis; adjuvant chemotherapy ; oral administration ; compliance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract.  Objective: Little is known about patient compliance with oral adjuvant chemotherapy. It is estimated to be poor especially in Japan, where it is still unusual for patients to be directly informed of their diagnosis of malignancy. 5-Fluorouracil (5-FU) was measured in hair samples to assess patient exposure to 5-FU, and its potential usefulness is discussed as an index of compliance with postoperative adjuvant chemotherapy. Methods: Hair samples obtained from 55 patients, who had received oral 5-FU (total dose 27-41 g) as postoperative adjuvant chemotherapy over a 6-month period, were used for the analysis of 5-FU. The drug was extracted from the hair using ethyl acetate, and its fluorescence derivatization was employed for measurement with HPLC. The detection limit of 5-FU in hair was 0.01 ppm. Results: In 22 out of 55 samples 5-FU content was under the detection limit, whereas in the remaining 33 samples the drug was detected in a range of 0.006-2.125 ng per hair strand; in addition, drug content showed a log-normal distribution. 5-FU was detected in the hair collected from those patients who were possibly compliant with the postoperative oral adjuvant chemotherapy. Conclusion: As many as 40% of the patients analysed were supposed to be much less compliant. Even in the possibly compliant patients, the degree of compliance with the therapy varied according to a log-normal distribution.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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