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Digitale Medien

Overexpression of p53 nuclear protein in premalignant and malignant laryngeal lesions (1999)

Nakashima, T. ; Wang, X.-F. ; Masuda, M. ; [weitere]

Springer

European archives of oto-rhino-laryngology and head & neck 256 (1999), S. S56

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Details

ISSN: 1434-4726

Schlagwort(e): Key words p53 nuclear marker ; Laryngeal ; hyperkeratosis ; Laryngeal carcinoma ; Immunohistochemistry

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract To investigate the role of p53 nuclear protein mutations in the initiation and progression of laryngeal carcinoma, 111 premalignant and malignant laryngeal lesions (19 specimens with hyperkeratosis and 92 with carcinoma) were studied immunohistochemically. Overexpression of p53 was observed in 8 cases (42%) of laryngeal hyperkeratosis and 44 cases (47%) of laryngeal carcinoma. However, the expression of p53 showed no relationship to patients’ clinical courses. Our study confirms that p53 overexpression can be found in laryngeal carcinogenesis and is an early event but not a useful prognostic marker.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/PL00014155

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