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  • 1
    Electronic Resource
    Electronic Resource
    Epstein-Barr virus in tumours (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 29 (1996), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The Epstein-Barr virus (EBV) is the best characterized human virus known to infect most people all over the world. In most cases, primary infection with EBV is asymptomatic and the virus persists life-long without causing any disease. The availability of sensitive detection methods, however, has led to the identification of a wide array of EBV-associated disease entities. Although nearly 9000 publications have been written since the first description of this virus in 1964, many questions concerning its function and infection patterns remain unanswered. The direct involvement of EBV in the pathogenesis of a disease has only been established for infectious mononucleosis and lymphoproliferative disorders in the setting of congenital or acquired immunodeficiency. Extensive investigations on the role of EBV infection in the pathogenesis of all other EBV-associated lymphoid and epithelial proliferations have led to the conclusion that EBV is not the primary causative agent but it can promote tumour development. Since the early steps in neoplastic development are difficult to assess, further studies are required to clarify the precise role of EBV infection. Furthermore, the clinical significance of the presence of EBV in neoplasia is largely unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1996.tb01414.x
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  • 2
    Electronic Resource
    Electronic Resource
    Low incidence of Epstein–Barr virus presence in primary cutaneous T-cell lymphoproliferations (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Multíple bíopsíes taken from 76 European human Immunodeficiency virus (HIV)-negative patients with primary cutaneous T-cell lymphoproliferations, including mycosis fungoides (MF), pleomorphic T-cell lymphoma (PMTCL). anaplastic large cell lympboma (ALCLI and lymphomatoid papulosis (LyP) were investigated for the presence of Epstein-Barr virus (EBV) through a combined approach. Polymerase chain reaction (PCR) was employed for EBV-DNA detection, in situ hybridization (ISH) for cellular localization of EBV-encoded nuclear RNAs (EBKR1 and EBER2) and immediate early Bam H-fragment: lower frame (BHLF) RNA. and immunohistology (IH) for the identification of EBV-encoded latent membrane protein 1 (LMP1) and of nuclear antigen (EBNA) 2 expression. EBV-DNA was detectable by PCR in 15 of 76 cases (19·7%). EBER-ISH combined with IH identified a variable, usually very low, number of infected neoplastic cells in only seven of the 15 EBV-ONA-harbouring cases. This discrepancy between the results obtained with PCR and ISH is apparently caused by the low number of the infected cells per tissue section. The PMTCL entity produced the greatest number of positive cases, whilst ALCL and LyP cases were almost constantly devoid of the virus. BHLF transcripts were not detectable in any case, nor did any of the EBER-positive cells show an LMP1 or EBNA2 expression. These data show that primary cutaneous T-cell lymphoproliferations display an infrequent association with a latent EBV infection and that the pathogenic role of the virus in the positive cases remains obscure as the virus frequently infects only a minority of the atypical cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb07613.x
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  • 3
    Electronic Resource
    Electronic Resource
    Primäre Hirnlymphome bei erworbenem Immundefektsyndrom Immunphänotypische und molekularpathologische Charakterisierung in der stereotaktischen Biopsie, Autopsie und Liquorzytologie (1995)
    Springer
    Der Pathologe 16 (1995), S. 75-80 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Aids ; Primäre Hirnlymphome ; Epstein-Barr Virus ; Immunglobulinschwerketten-Genumlagerung ; Key words AIDS ; Primary malignant lymphoma of the brain ; Epstein-Barr virus ; Ig heavy-chain rearrangements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In this study we present morphological, cytological, immunophenotypical, and molecular genetic features of ten cases of AIDS-related primary brain lymphomas obtained as sterotactic biopsies, autopsy specimens, or cerebrospinal fluid samples. Histologically, a very characteristic perivascular and diffuse lymphomatous spread in the brain parenchyma was observed. By applying a highly sensitive in situ hybridization technique (ISH) using digoxigenin-labeled anti-sense riboprobes, abundant Epstein-Barr virus (EBV)-encoded small nuclear RNAs (EBER) transcripts could be demonstrated in each case studied. A combination of ISH with immunohistochemical staining for latent membrane protein (LMP-1) and EBV nuclear antigen-2 (EBNA-2) showed different patterns of EBV latency with a predominance of the broad spectrum (EBER+/EBNA-2+/LMP-1+). Clonal rearrangements of immunoglobulin heavy chain (IgH) genes were demonstrated in four cases using a sensitive polymerase chain reaction. In one patient the rearrangement pattern suggested biclonal lymphoproliferation. Our observations confirm the implication of the EBV in the etiology of AIDS-related primary malignant lymphomas of the brain. The demonstration of EBV gene products and clonal IgH rearrangements even in small biopsy samples is a useful tool for distinguishing between reactive and neoplastic lymphocytic infiltrates, which are frequently observed in brain and cerebrospinal fluid specimens obtained from AIDS patients.
    Notes: Zusammenfassung In der vorliegenden Untersuchung stellen wir typische morphologische, zytologische, immunphänotypische und molekulargenetische Merkmale von 10 Fällen Aids-assoziierter Hirnlymphome vor, die als stereotaktische Biopsien, Autopsiematerial oder Liquorpunktate vorlagen. Mit einer hochsensitiven In-situ-Hybridisierungstechnik (ISH) unter Verwendung von digoxigeninmarkierten Antisensesonden konnten sehr zahlreiche Epstein-Barr-Virus(EBV-)kodierte kurze nukleäre RNA(EBER)-Transkripte in jedem der untersuchten Fälle dargestellt werden. Eine Kombination der ISH mit immunhistochemischen Färbungen zum Nachweis des latenten Membranproteins (LMP-1) und des EBV-Kernantigens-2 (EBNA-2) zeigte unterschiedliche Muster der EBV-Latenz mit Prädominanz des sog. „breiten Spektrums“ (EBER+/EBNA-2+/LMP-1+). Mit einer sensitiven Polymerasekettenreaktion (PCR) konnten klonale Immunglobulinschwerketten (IgH)-Genumlagerungen in 4 Fällen nachgeweisen werden. Bei einem Patienten war eine biklonale Lymphoproliferation nicht auszuschließen. Unsere Beobachtungen unterstreichen die Bedeutung des EBV bei der Entstehung primärer Aids-assoziierter Hirnlymphome. Der Nachweis von EBV-Genprodukten und die Klonalitätsanalyse mit Hilfe der PCR können einen wichtigen Beitrag zur differentialdiagnostischen Abgrenzung von reaktiven entzündlichen gegenüber neoplastischen lymphoiden Infiltraten leisten, die bei Aids-Patienten häufig im Hirngewebe und Liquor beobachtet werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050079
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  • 4
    Electronic Resource
    Electronic Resource
    Non-Hodgkin-Lymphome (1997)
    Springer
    Der Onkologe 3 (1997), S. 488-497 
    Details
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Für die meisten malignen Tumoren des Menschen existieren weltweit akzeptierte einheitliche Klassifikationsschemata. Dies trifft leider nicht für die Non-Hodgkin-Lymphome (NHL) zu. Seit 1966 wurden mehr als 8 verschiedene Klassifikationen vorgeschlagen (Tabelle 1). Davon haben sich die „working formula- tion” (WF) auf den amerikanischen Kontinenten und die Kiel-Klassifikation in Europa durchgesetzt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007610050146
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