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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 24 (1998), S. 313-321 
    ISSN: 1432-1238
    Keywords: Key words Cardiopulmonary bypass ; Hypothermic ; Pulsatile ; Heart ; open heart surgery ; Coronary artery bypass graft ; Haematocrit ; Haemoglobin ; concentration ; Oxygen ; content ; Perfusion ; splanchnic ; Tonometry ; gastric ; Gastric mucosal pH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Acute normovolaemic haemodilution with subsequent autologous blood transfusion after surgery is widely used to reduce homologous blood requirements during cardiac surgery. The hypothesis tested was whether a low intraoperative haematocrit (Hct) resulting from haemodilution decreases gastric mucosal pH (pHi). Design: Prospective clinical investigation. Setting: University Hospital of Vienna, Austria. Patients: 16 consecutive patients scheduled for elective cardiac surgery. Interventions: The patients were randomly assigned to one of two groups: In 10 patients (group 1), 500 ml of blood was withdrawn and stored after anaesthesia induction. An equal amount of 6 % hydroxyethyl starch was simultaneously infused. After discontinuation of cardiopulmonary bypass (CPB), the autologous blood unit was transfused. Six patients (group 2), who were not subjected to haemodilution and autologous blood transfusion served as controls. In all patients, a gastric tonometry probe was inserted. Measurements and results: Measurements of pHi and Hct were performed before and after acute normovolaemic haemodilution, during pulsatile hypothermic (30–32 °C) CPB, after rewarming, and 30 min after autologous blood transfusion in group 1, and at corresponding time intervals in group 2. Repeated measures analysis of variance and the Mann–Whitney U test were used for statistical analysis. Data are presented as means ± standard error of the mean. Haemodilution in group 1 caused a significant and persistent decrease in Hct (after haemodilution in group 1 34 ± 1 vs 40 ± 1 % in group 2). In both groups, pHi decreased during rewarming and after termination of CPB. However, in group 1, pHi was better preserved than in group 2 (rewarming: 7.44 ± 0.02 vs 7.34 ± 0.04; after CPB: 7.38 ± 0.03 vs 7.28 ± 0.02; p 〈 0.05). Conclusions: Acute normovolaemic haemodilution does not aggravate gastric mucosal acidosis during cardiac surgery.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 398 (1999), S. 694-697 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The El Niño/Southern Oscillation (ENSO) phenomenon is the strongest natural interannual climate fluctuation. ENSO originates in the tropical Pacific Ocean and has large effects on the ecology of the region, but it also influences the entire global climate system and affects the societies ...
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1476-5535
    Keywords: Keywords: Bacillus subtilis; riboflavin; 3,4-dihydroxy-2-butanone 4-phosphate synthase; GTP cyclohydrolase II
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: One of the proteins encoded by the riboflavin operon of Bacillus subtilis, RibA, was identified as the rate limiting enzyme in an industrial riboflavin producing strain. An additional single copy of the ribA gene was introduced into the sacB locus of the riboflavin production strain and was expressed constitutively from the medium strength vegI promoter. This led to improved riboflavin titers and yields of riboflavin on glucose of up to 25%. Both enzymatic activities of RibA, the 3,4-dihydroxy-2-butanone 4-phosphate synthase activity located in the N-terminal half of the protein and the GTP cyclohydrolase II activity of the C-terminal domain, are necessary for the improved riboflavin productivity.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0894
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract. The interannual variability associated with the El Niño/Southern Oscillation (ENSO) cycle is investigated using a relatively high-resolution (T42) coupled general circulation model (CGCM) of the atmosphere and ocean. Although the flux correction is restricted to annual means of heat and freshwater, the annual as well as the seasonal climate of the CGCM is in good agreement with that of the atmospheric model component forced with observed sea surface temperatures (SSTs). During a 100-year simulation of the present-day climate, the model is able to capture many features of the observed interannual SST variability in the tropical Pacific. This includes amplitude, lifetime and frequency of occurrence of El Niño events and also the phase locking of the SST anomalies to the annual cycle. Although the SST warming during the evolution of El Niños is too confined spatially, and the warming along the Peruvian coast is much too weak, the patterns and magnitudes of key atmospheric anomalies such as westerly wind stress and precipitation, and also their eastward migration from the western to the central equatorial Pacific is in accord with observations. There is also a qualitative agreement with the results obtained from the atmospheric model forced with observed SSTs from 1979 through 1994. The large-scale dynamic response during the mature phase of ENSO (December through February) is characterized by an eastward displacement and weakening of the Walker cell in the Pacific while the Hadley cell intensifies and moves equatorward. Similar to the observations, there is a positive correlation between tropical Pacific SST and the winter circulation in the North Pacific. The deepening of the Aleutian low during the ENSO winters is well captured by the model as well as the cooling in the central North Pacific and the warming over Canada and Alaska. However, there are indications that the anomalies of both SST and atmospheric circulation are overemphasized in the North Pacific. Finally, there is evidence of a coherent downstream effect over the North Atlantic as indicated by negative correlations between the PNA index and the NAO index, for example. The weakening of the westerlies across the North Atlantic in ENSO winters which is related to a weakening and southwestward displacement of the Icelandic low, is in broad agreement with the observations, as well as the weak tendency for colder than normal winters in Europe.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Climate dynamics 14 (1998), S. 725-740 
    ISSN: 1432-0894
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract  This work concerns an analysis of inter-basin and inter-layer exchanges in the component ocean part of the coupled ECHAM4/OPYC3 general circulation model, aimed at documenting the simulation of North Atlantic Deep Water (NADW) and related thermohaline circulations in the Indian and Pacific Oceans. The modeled NADW is formed mainly in the Greenland– Iceland–Norwegian Seas through a composite effect of deep convection and downward cross-isopycnal transport. The modeled deep-layer outflow of NADW can reach 16 Sv near 30 °S in the South Atlantic, with the corresponding upper-layer return flow mainly coming from the “cold water path” through Drake Passage. Less than 4 Sv of the Agulhas “leakage” water contributes to the replacement of NADW along the “warm water path”. In the South Atlantic Ocean, the model shows that some intermediate isopycnal layers with potential densities ranging between 27.0 and 27.5 are the major water source that compensate the NADW return flow and enhance the Circumpolar Deep Water (CDW) flowing from the Atlantic into Indian Ocean. The modeled thermohaline circulations in the Indian and Pacific Oceans indicate that the Indian Ocean may play the major role in converting deep water into intermediate water. About 16 Sv of the CDW-originating deep water enters the Indian Ocean northward of 31 °S, of which more than 13 Sv “upwell” mainly near the continental boundaries of Africa, South Asia and Australia through inter-layer exchanges and return to the Antarctic Circumpolar Current (ACC) as intermediate-layer water. As a contrast, only 4 Sv of Pacific intermediate water is connected to “upwelling” flow southward across 31 °S while the magnitude of northward deep flow across 31 °S in the Pacific Ocean is significantly greater than that in the Indian Ocean. The model suggests that a large portion of the deep waters entering the Pacific Ocean (about 14 Sv) “upwells” continually into some upper layers through the thermocline, and becomes the source of the Indonesian throughflow. Uncertainties in these results may be related to the incomplete adjustment of the model’s isopycnal layers and the sensitivity of the Indonesian throughflow to the model’s geography and topography.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0894
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract  The new version of the atmospheric general circulation model (AGCM), ECHAM4, at the Max Planck Institute for Meteorology, Hamburg, has been coupled to the OPYC3 isopycnic global ocean general circulation and sea ice model in a multi-century present-day climate simulation. Non-seasonal constant flux adjustment for heat and freshwater was employed to ensure a long-term annual mean state close to present-day climatology. This study examines the simulated upper ocean seasonal cycle and interannual variability in the tropical Pacific for the first 100 years. The coupled model’s seasonal cycle of tropical Pacific SSTs is satisfactory with respect to both the warm pool variation and the Central and Eastern Pacific, with significant errors only in the cold tongue around April. The cold phase cold tongue extent and strength is as observed, and for this the heat flux adjustment does not play a decisive role. A well-established South Pacific convergence zone is characteristic for the new AGCM version. Apart from extending the southeast trades seasonal maximum to midbasin, wind stress pattern and strength are captured. Overall the subsurface structure is consistent with the observed, with a pronounced thermocline at about 150 m depth in the west and rising to the surface from 160 °W to 100 °W. The current system is better resolved than in some previous global models and, on the whole, has the expected shape. The equatorial undercurrent is correctly positioned but the core is only half as strong as observed. The north equatorial current and counter-current also have reduced maximum speeds but the April minimum is captured. As with the companion publication from Roeckner et al. this study finds pronounced tropical Eastern and Central Pacific interannual variability. Simulated and observed NINO3 sea surface temperature (SST) variability is represented by a single, rather broadband, maximum of power spectral density, centered on about 28 months for the simulation and four years for the observations. For simulation and observations, SST, windstress, and upper ocean heat content each exhibit a single dominant large-scale amplitude and phase pattern, suggesting that the model captures the essential dynamics. The amplitude of the essentially standing oscillation in SST in the NINO3 region attains the observed strength, but is weaker at the eastern boundary. Anomalies of upper ocean heat content show off-equatorial westward and equatorial eastward propagation, the latter’s arrival in the east of the basin coinciding with the SST anomalies. Equatorial wind stress anomalies near the date line provide the appropriate forcing and clearly form a response to the anomalous SST.
    Type of Medium: Electronic Resource
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