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  • 1
    Electronic Resource
    Electronic Resource
    Calcitonin gene-related peptide- and substance P-immunoreactive axons in the nucleus gracilis of the rat with special reference to axonal dystrophy: light and electron microscopic observations (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 347-355 
    Details
    ISSN: 1432-0533
    Keywords: Nucleus gracilis ; Axonal dystrophy ; Calcitonin gene-related peptide ; Substance P ; Immunoelectron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Calcitonin gene-related peptide (CGRP) and substance P (SP)-immunoreactive (IR) axons in the nucleus gracilis of normal rats (1–15 months of age) were studied by light and electron microscopy. Besides many CGRP-IR and SP-IR varicosities with normal appearance, we found a few swollen (nearly round or oval) varicosities with either CGRP or SP immunoreactivity. Swollen CGRP-IR varicosities were more frequently seen than SP-IR ones, appearing from 3 months of age and increasing in number and size (up to approximately 25 μm in diameter) with advancing age. At the electron microscopic (EM) level, CGRP-IR and SP-IR swollen varicosities showed dystrophic changes, i.e., many membranous dense bodies, and proliferation of microtubules and neurofilaments. CGRP-IR or SP-IR dystrophic axons also contained many mitochondria and sometimes made synaptic contacts with nonreactive dendrites (occasionally with non-IR axons). These findings suggest that the dystrophic CGRP and SP axonal profiles represent a functionally distinct subpopulation of axonal dystrophy in the nucleus gracilis and use CGRP or SP as a neuroactive substance. Using a double-immunostaining method, many of normal CGRP-IR axons were identified to be SP-IR. However, no single dystrophic varicosity was found to contain both CGRP and SP immunoreactivities. These findings suggest that CGRP and SP afferents are independently affected and progress to dystrophic changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315008
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  • 2
    Electronic Resource
    Electronic Resource
    Peripheral cholangiocarcinoma: comparison of MRI with CT (1995)
    Springer
    Abdominal imaging 20 (1995), S. 357-360 
    Details
    ISSN: 1432-0509
    Keywords: Liver ; Cholangiocarcinoma ; CT ; Magnetic resonance ; Liver neoplasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the clinical utility of computed tomography (CT) and magnetic resonance imaging (MRI) in the diagnosis of peripheral cholangiocarcinoma of the liver, 11 patients with pathologically proven peripheral cholangiocarcinoma were examined with both CT and MRI. On CT scans in 10 cases, the tumors appeared as irregular, low-attenuation masses with a wide variation in heterogeneity. Contrast enhancement of the tumors was mild in nine cases and moderate in one case, at the periphery. Tumor was not identified in one case. On T1-weighted MRIs, the tumors showed low intensity in eight cases and isointensity in three cases. On T2-weighted images, the tumors showed high intensity in all 11 cases. Focal dilatation of the intrahepatic bile ducts around the tumor was seen in one case on MRIs and in four cases on CT scans. Portal vein invasion of the tumors was seen in one case, and lymphadenopathy was seen in four cases on both MRIs and CT scans. MRI was slightly superior to CT in detecting the tumors, was inferior to CT in delineating focal ductal dilatation around the tumors, and was equal to CT in assessing extent of the tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203371
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Hepatic involvement in hypereosinophilic syndrome: value of portal venous phase imaging (1998)
    Springer
    Abdominal imaging 23 (1998), S. 154-157 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Liver, hypereosinophilic syndrome—Liver, utrasonography—Liver, CT—Liver, MRI.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. US, portal venous phase CT, and MRI-CSE (MRI with conventional spin-echo sequence) findings in three cases of hepatic involvement in hypereosinophilic syndrome are presented. These showed varied imaging findings, but portal venous phase CT showed multiple, poorly marginated, and hypodense hepatic lesions in all three cases. The result suggested that portal venous phase CT is the optimal method for depicting hepatic involvement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900310
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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