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  • 1995-1999  (2)
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  • 1
    ISSN: 1365-3180
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: A total of 74 independently run bioassays with soil incorporated metsulfuron-methyl from 12 different laboratories was analysed by a logistic dose-response curve to assess the precision of regression parameters and relate ED50 to soil properties. The potency in terms of ED50 of metsulfuron-methyl in Brassica rapa L., which was used by all laboratories, varied between 0.05 and 3.9 g a.i. ha-1. ED50 was negatively correlated with pH and positively correlated with organic matter. The majority of laboratories had ED50 within the interval 0.1-1.0 g a.i. ha-1. At one laboratory using three test species, the most sensitive species was Beta vulgaris L. followed by Brassica rapa L. and Lepidium sativum L. The coefficients of variation were smallest for the ED50 and ED90 response levels and largest for the ED10. The slope of the response curves had considerably lower coefficients of variation than the EDs. The results are discussed in relation to a previous collaborative bioassay study. Finally it is suggested that standardization of bioassays with herbicides could be achieved in the same way as standardization of chemical analyses.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation 20 (1996), S. 11-21 
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Extracellular adenosine has pharmacological activity on a wide variety of cell types and may play an important role as an inflammatory modulator with both pro- and anti-inflammatory activities. These studies examine the effects of adenosine on guinea pig pulmonary eosinophils. Adenosine alone did not directly induce superoxide (O 2 − ) production. Pretreatment with adenosine primed the O 2 − response of guinea pig pulmonary eosinophils following the addition of 1 or 10μM plateletactivating factor (PAF). Priming was seen at adenosine concentrations greater than 1 μM and was maximal at 100μM. At this maximal dose, adenosine priming increased the O 2 − response to 1μM and 10μM PAF by 86% and 51%, respectively. Priming by adenosine was not seen when ionomycin or phorbol myristate acid (PMA) were used as agonists. In fura-2 loaded eosinophils, the addition of 100 μM adenosine resulted in a small but significant rise in intracellular calcium of 54.4 ±9.2 nM above baseline. In contrast, similar adenosine concentrations had no effect on cytosolic calcium levels in guinea pig neutrophils. These data demonstrate a pro-inflammatory role for adenosine in elicited guinea pig pulmonary eosinophils.
    Type of Medium: Electronic Resource
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