Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Regional body composition determined by dual-energy x-ray absorptiometry. Relation to Training, Sex Hormones, and serum lipids in male long-distance runners (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of medicine & science in sports 8 (1998), S. 0 
    Details
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: This study investigated the regional distribution of fatty and lean tissue in long-distance runners, and the relation to training, sex hormones, and serum lipids. One hundred and twenty lean men (22 elite, 86 recreational runners and 12 non-running controls) aged 32±8.1 years (mean±SD) participated. Body composition (adipose and lean tissue) was measured by dual-energy x-ray absorptiometry in the total body and in the abdomen, the arms and the legs. Regional and total body fat correlated inversely with the performance at an incremental treadmill exercise test (−0.61〈r〈−0.52, P〈0.0001), and the fat percentage in the abdomen and in the legs was 42% and 36% lower in the elite runners in comparison with the non-running controls. Sex hormonal status and serum lipids were unrelated to training. After multiple regression analysis the most significant determinant of the fat percentage in the legs was the weekly distance run (partial r=−0.40, P〈0.0001), whereas in the abdominal region the free testosterone index also contributed strongly (partial r=0.39, P〈0.0001). In conclusion, long-distance runners had very low amounts of fatty tissue in the abdomen and in the extremities, and the fat percentages in the abdomen and in the legs were associated with both the training intensity and androgenic activity. Since the abdominal fatty tissue is a significant risk factor for cardiovascular disease, running may have a positive impact on the long-term risk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0838.1998.tb00176.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Early postmenopausal diminution of forearm and spinal bone mineral density: A cross-sectional study (1995)
    Springer
    Osteoporosis international 5 (1995), S. 35-38 
    Details
    ISSN: 1433-2965
    Keywords: Bone loss ; Dual-energy X-ray absorptiometry ; Lateral ; Postmenopausal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Diminution of bone mineral density (BMD) in the spine and forearm was studied cross-sectionally in 363 women who were 6 months to 10 years postmenopausal. BMD was determined by dual-energy X-ray absorptiometry (DXA) (Hologic QDR-2000) in the lumbar spine, in both the supine lateral (LAT) and anteroposterior (AP) projections, and in the distal third of the forearm. The postmenopausal diminution of BMD was best described by an exponential fit. The initial rate of postmenopausal diminution of BMD was highest in the most trabecular sites (LAT〉AP〉 forearm), but 10-year diminution was similar at all sites (12%–13%, corresponding to about 1.0–1.5 SD), and extrapolation suggested reverse order of the rates of diminution thereafter (forearm〉AP〉LAT). When bone mineral content of the entire L3 vertebra (tBMC) was measured in vivo, AP tBMC could account for only 67% of the variation in LAT tBMC, compared withr 2=0.997 in vitro. This observation suggests an accuracy problem in vivo in one of the spine measurement methods. We conclude that the initial rate of BMD diminution after the menopause seems to be highest in the spine, especially when measured laterally, but that this rate levels off within the first decade. The lower precision error of a forearm measurement (0.8% v 1.6 for AP and 3.1 for LAT) therefore implies that this method may require a shorter observation period than spine measurements for the detection of bone loss 5–10 years after menopause. Long-term longitudinal spine and forearm measurements are, however, needed to confirm these conclusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01623656
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Circadian rhythm in type I collagen formation in postmenopausal women with and without osteopenia (1995)
    Springer
    Osteoporosis international 5 (1995), S. 472-477 
    Details
    ISSN: 1433-2965
    Keywords: Circadian rhythm ; Cosinor analysis ; Osteopenia ; Postmenopause ; Procollagen type I carboxyl-terminal propeptide (PICP)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A circadian rhythm in the serum concentration of the procollagen type I carboxyl-terminal propeptide (sPICP) has previously been demonstrated in premenopausal women. This study was performed to investigate the circadian rhythm in sPICP in healthy and osteopenic postmenopausal women. Blood samples were taken every third hour for 27 h from three groups of women: 12 early postmenopausal women (aged 55±2 years; mean±SD); 12 late postmenopausal women (aged 73±1 years); and 12 osteopenic but otherwise healthy late postmenopausal women (aged 73±1 years). A circadian rhythm in sPICP was found in all three groups, as shown by cosinor analysis (p=0.000003−0.03). The circadian rhythm in sPICP was significantly different between the osteopenic group and the age-matched healthy group (p〈0.008). The amplitude of the circadian rhythm in sPICP was about twice as high in the osteopenic group, and the time of the maximum tended to be about 3 h later, as compared with the age-matched healthy group. The plasma concentration of osteocalcin, as measured by a recently developed two-site enzyme-linked immunosorbent assay, also showed a circadian rhythm in all three groups (p=0.0001−0.05), with no significant differences between groups. In conclusion, we have found a significant circadian rhythm in sPICP in both early and late postmenopausal women. In osteopenic women the nightly peak in sPICP is larger and persists later into the night as compared with non-osteopenic women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01626611
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The impact of degenerative conditions in the spine on bone mineral density and fracture risk prediction (1996)
    Springer
    Osteoporosis international 6 (1996), S. 43-49 
    Details
    ISSN: 1433-2965
    Keywords: Bone densitometry ; Degenerative conditions ; Fracture risk ; Osteophytosis ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the impact of degenerative conditions in the spine (osteophytosis and endplate sclerosis) and aortic calcification in the lumbar region on bone mineral content/density (BMC/BMD) measured in the spine and forearm by absorptiometry and on fracture risk prediction. The radiographs of 387 healthy postmenopausal women, aged 68–72 years, were assessed in masked fashion for the presence of osteophytosis, endplate sclerosis and aortic calcification in the region from L2 to L4. Vertebral deformities/fractures were assessed by different definitions. Osteophytes larger than 3 mm and in numbers of 3 or more resulted in a significantly (12%) higher spinal bone mass (p〈0.001). Endplate sclerosis had a similar effect (p〈0.001). In subjects with both degenerative conditions the BMC/BMD in the spine and forearm were significantly higher than in unaffected women (19% in the spine, 10% in the forearm;p〈0.001). The spinal BMD values were significantly lower in fractured women if both degenerative conditions were absent (p〈0.001), whereas fractured and unfractured women had similar values if degenerative conditions were present. Degenerative conditions did not alter the ability of forearm BMC to discriminate vertebral or peripheral fractures. Receiver operating characteristic (ROC) curves (true positive fraction versus false positive fraction) were generated for BMD of the lumbar spine and BMC of the forearm with regard to the discrimination between women with vertebral and peripheral fractures and healthy premenopausal women. The ROC curves for women without degenerative conditins were consistently above the curves for women affected by osteophytosis and endplate sclerosis in the lumbar spine (p〈0.001). In conclusion, osteophytes and endplate sclerosis have a considerable influence on spinal bone mass measurements in elderly postmenopausal women and affect the diagnostic ability of spinal scans to discriminate osteoporotic women. Our data suggest that in elderly women, unless the spine is radiologically clear of degenerative conditions, a peripheral measurement procedure should be considered an alternative for assessment of bone mineral content/ensity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01626537
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Cost-effectiveness of fracture prevention in established osteoporosis (1995)
    Springer
    Osteoporosis international 5 (1995), S. 136-142 
    Details
    ISSN: 1433-2965
    Keywords: Cost-effectiveness ; Fracture ; Model ; Osteoporosis ; Prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study presents the results of a computer simulation model for calculating the cost-effectiveness and cost-utility of treating patients with established osteoporosis in order to reduce the risk of fractures. The results are based on Swedish data for risk of fracture and costs. The treatment intervention modelled is based on treatment of a 62-year-old woman with established osteoporosis. The cost per hip fracture avoided is 350000 SEK, assuming a 50% reduction in the risk of fracture due to 5 years of treatment. A sensitivity analysis for changes in the cost and effectiveness of treatment, the risk of fracture and the discount rate is performed. The cost per life-year gained and the cost per quality-adjusted life-year (QALY) gained is presented to enable comparison of the cost-effectiveness of treating osteoporosis with that of other health care interventions. A comparison between treating the same woman for osteoporosis and mild hypertension shows a cost per life-year gained of 220000 SEK and 128000 SEK respectively. Cost per QALY gained is very similar for the two interventions: 105 000 SEK and 103 000 SEK respectively. This model provides a tool to enable clinicians, administrators and health policy makers to analyze and understand the economic aspects of a major health policy issue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01623315
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Biochemical markers of bone turnover to monitor the bone response to postmenopausal hormone replacement therapy (1995)
    Springer
    Osteoporosis international 5 (1995), S. 276-280 
    Details
    ISSN: 1433-2965
    Keywords: Bone loss ; Bone markers ; Treatment follow-up
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hormone replacement therapy (HRT) prevents postmenopausal bone loss, and is therefore increasingly prescribed to prevent the development of postmenopausal osteoporosis. Because of individual differences in the response to HRT as well as problems with compliance, it has been debated how the skeletal response to HRT should be monitored. When estrogen production decreases at the menopause, a number of biochemical markers of bone turnover increase considerably in the order of 50%–100% from baseline. When HRT is instituted, the markers decrease again within the following 3–6 months. In the present prospective study we investigated whether the determination of biochemical markers of bone turnover may be useful for monitoring the skeletal effect of HRT. Seventy-six early postmenopausal women received HRT and 43 received placebo. The treatment period was 24 months and the women were followed with repeated bone mass measurements (every 3 months) which allowed calculation of the bone loss. Serum and urine samples were collected at 3, 6, 12 and 24 months. The placebo group lost a significant amount of bone mineral density in both the forearm and the spine (p〈0.001), whereas the HRT group did not. There was, however, a relatively large overlap of values between the HRT and placebo groups, especially in the spine. After 3 months' treatment the correlation between the changes in the markers and the bone loss wasr=0.59, and this value increased tor=0.66 at 6 months andr=0.76 andr=0.77 at 12 and 24 months, respectively. The present study thus indicates that biochemical markers of bone turnover may be of value for monitoring the bone response to HRT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01774018
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    A 2-Year Phase II Study with 1-Year of Follow-up of Risedronate (NE-58095) in Postmenopausal Osteoporosis (1997)
    Springer
    Osteoporosis international 7 (1997), S. 488-495 
    Details
    ISSN: 1433-2965
    Keywords: Keywords: Bisphosphonates; Postmenopausal osteoporosis; Risedronate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: This paper presents the results of a two-center, double-masked, placebo-controlled, randomized, oral-dose study of risedronate treatment in postmenopausal osteoporosis. Patients had at least one, but no more than four prevalent vertebral fractures at baseline. They received either 2.5 mg continuous risedronate, 2.5 mg cyclic risedronate, or placebo for 2 years. Both risedronate and placebo were formulated as hard gelatin capsules. All women furthermore received a daily calcium supplement of 1 g which was taken separately from the study drug. During the 1-year of follow-up, all women received only a daily calcium supplement of 1 g. A total of 132 patients were enrolled (44 in each treatment group), of which 73% completed the 2-year treatment period and 70% all 3 years. Generally the outcome of the study was negative. Lumbar spine bone mineral density (BMD) increased 1.2% (NS) and 0.8% (NS) and after 2 and 3 years in the group treated with continuous risedronate, 1.7% (NS) and 2.3% (p 〈 0.05) in the group treated with cyclic risedronate, and 0.6% (NS) and 1.7% (NS) in the placebo group. BMD in the femoral neck increased 2.9% (p 〈 0.05) and 0.9% (NS) after 2 and 3 years in the group treated with continuous risedronate, 1.3% (NS) and 2.4% (p 〈 0.01) in the group treated with cyclic risedronate, and 1.3% (NS) and 2.6% (p 〈 0.01) in the placebo group. The differences between all three groups in spinal and femoral BMD after 2 years were not statistically significant, bur reached statistical significance after 3 years (p 〈 0.01) in the femoral neck. Only minor changes were observed in the measured markers of bone turnover. Both the incidence and rate of new vertebral fractures showed no overall differences between the groups. The distribution of adverse events was similar across treatment groups. None of the serious adverse events were considered causally related to risedronate. The lack of effect shown in the present study may be explained by insufficient dose regimen and/or impaired absorption from the intestinal tract. Further investigations (ongoing phase III trials) are needed to define future dose regimens in order to validate the effect on bone mass, fracture rate and biochemical markers. In these studies another formulation of the drug and other dosing instructions are used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00004152
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Sex Steroid Analogs (1999)
    Springer
    Osteoporosis international 9 (1999), S. S62 
    Details
    ISSN: 1433-2965
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00004163
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Anteroposterior and lateral spinal DXA for the assessment of vertebral body strength: Comparison with hip and forearm measurement (1996)
    Springer
    Osteoporosis international 6 (1996), S. 37-42 
    Details
    ISSN: 1433-2965
    Keywords: Bone strength ; Human spine ; Lateral DXA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Spinal bone mineral density (BMD) is traditionally measured by dual-energy X-ray absorptiometry (DXA) in the anteroposterior (AP) projection which includes both the vertebral body and the posterior elements in the measurement. The posterior elements, however, contribute little to the compressive strength of the spine. It has therefore been suggested that spinal BMD measured in the lateral projection, including only the vertebral body in the measurement, might be more appropriate for the prediction of fracture risk. To date little clinical evidence has been presented to support this assumption. To address the issue, we measured vertebral, hip and forearm BMD in situ in 14 human cadavers and remeasured BMD in vitro in excised vertebrae. Lateral spinal measurements were performed in the decubitus position. Fracture force and other bio-mechanical measures were determined for 32 vertebrae in a mechanical testing machine and compared with BMD values in situ and in vitro. Correlations of BMD with vertebral fracture force werer=0.48/0.51 (in situ/in vitro) for the AP spinal measurements,r=0.45/0.71 (in situ/in vitro) for the lateral spinal measurements, andr=0.64 andr=0.53 for total hip and forearm measurements in situ, respectively. Thus, despite an apparent diagnostic advantage in vitro, lateral spinal BMD measurement was not superior to AP measurement when performed in situ. This observation corresponds well with previous clinical findings and is probably due to the larger accuracy error in the lateral than in the AP projection resulting from a lower ratio of bone to soft tissue. The high correlation between hip BMD and vertebral fracture force suggests that hip measurement may prove as useful for vertebral fracture risk assessment as spinal measurement in any projection, especially in the elderly with a high prevalence of degenerative changes in the spine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01626536
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Sex steroids and the cardiovascular system (1997)
    Springer
    Osteoporosis international 7 (1997), S. 8-11 
    Details
    ISSN: 1433-2965
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary HRT decreases significantly the risk of cardiovascular disease in postmenopausal women. More and more data indicate that this is true not only for unopposed oestrogen but also for combined oestrogen/progestin therapy. The latter point is of utmost importance since the global treatment strategy for women with an intact uterus includes a progestin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01674806
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...