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Xenoislet transplantation: experimental and clinical aspects (1999)

Groth, C. G. ; Tibell, A. ; Wennberg, L. ; [et al.]

Springer

Journal of molecular medicine 77 (1999), S. 153-154

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ISSN: 1432-1440

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Ten diabetic renal transplant patients had porcine fetal islet-like cell clusters (ICC) injected intraportally or placed under the kidney capsule. In some patients, temporary graft survival was achieved, as evidenced by the urinary excretion of small amounts of porcine C-peptide (4 patients) and the identification of some intact insulin-staining cells in a biopsy specimen (1 patient). Glucose metabolism remained unaffected. To improve the results, better islets and better immunosuppressive protocols are required. We found that, while fetal porcine ICC produced insulin only after several weeks, adult islets gave immediate insulin production. The search for an optimal immunosuppression was conducted in the pig-to-rat islet transplant model. A clear inhibitory effect on the xenograft rejection was observed when using some of the new drugs. The best results were achieved with a triple drug regimen consisting of cyclosporine, mycophenolate mofetil and leflunomide.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s001090050325

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No viral disease after xenotransplantation (1998)

Tibell, A. ; Groth, C. G.

[s.l.] : Macmillan Magazines Ltd.

Nature 392 (1998), S. 646-646

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] SirYou refer in your Briefing on xenotransplantation (Nature 391, 320–325; 1998) to a study on seroreactivity to porcine viruses in the ten diabetic patients transplanted with fetal pig islets in Stockholm, Sweden, ...