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  • 1
    Electronic Resource
    Electronic Resource
    Long-term metabolic control after pancreas transplantation with enteric exocrine diversion (1991)
    Springer
    Diabetologia 34 (1991), S. S76 
    Details
    ISSN: 1432-0428
    Keywords: Glucose ; Lipids ; Lipoproteins ; Pancreatic graft rejection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Long-term metabolic control after pancreatic transplantation with enteric exocrine diversion was evaluated in 42 Type I (insulin-dependent) diabetic pancreas recipients with functioning grafts for 1 to 7 years. Glycaemic control (fasting blood glucose, glycosylated haemoglobin A1c, oral and intravenous glucose tolerance tests) was normal or near-normal in most patients, and showed no deterioration with time. In ten patients with functioning grafts for 5 years there was a small, but significant, improvement in the glucose control at 3 to 5 years as compared with that at 6 months post-operatively. In the latter recipients the number of acute rejection episodes correlated negatively with the intravenous glucose tolerance at 6 months (r=−0.64, p〈0.01) and at 5 years (r=−0.60, p〈0.01) after transplantation, respectively. The glycaemic control at 6 and 12 months after transplantation was similar whether segmental (n=35) or whole-organ (n=7) pancreatic grafts had been used. In six non-uraemic recipients who had received a pancreas transplant alone the serum cholesterol increased in all but one patient (0.05〈p〈0.1), and the LDL/HDL-cholesterol ratio was significantly higher (p〈0.005) one year after transplantation than before. Conversely, in six diabetic patients who had lost the function of their single pancreatic grafts the lipid and lipoprotein profiles remained unaltered. It is concluded that the long-term glycaemic control after segmental or whole-organ pancreatic transplantation with enteric exocrine diversion remains essentially normal in most recipients, and it may even improve with time. The short- and long-term glucose control seems to be adversely influenced by the number of acute rejections. Moreover, in non-uraemic pancreas transplant recipients the lipoprotein profile changed towards a more atherogenic pattern. The latter findings are probably attributable to the immunosuppressive therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587625
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  • 2
    Electronic Resource
    Electronic Resource
    The Stockholm experience with pancreatic transplantation using enteric exocrine diversion (1991)
    Springer
    Diabetologia 34 (1991), S. S21 
    Details
    ISSN: 1432-0428
    Keywords: Pancreatic transplantation ; Human ; Enteric diversion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between April 1974 and June 1990, 128 pancreatic transplantations were performed. Of these 117 were with pancreatico-enterostomy. In four consecutive series of combined transplantations in uraemic diabetic patients the 1-year graft survival rate have successively improved (27%, 65%, 68% and 73%). In three similar series of single pancreatic transplantations the results also improved but still remained inferior (0%, 33% and 33%). In a series of combined transplantations performed in preuraemic diabetic patients the 1-year actuarial graft survival rate was only 25%. The results with pancreatic transplantation with pancreatico-enterostomy are now satisfactory. However, immunological loss graft function still constitute a major problem in the non- or preuraemic recipients. The metabolic control in patients with functioning grafts is normal or near-normal in the majority of patients followed for at least 1 year.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587613
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  • 3
    Electronic Resource
    Electronic Resource
    Xenoislet transplantation: experimental and clinical aspects (1999)
    Springer
    Journal of molecular medicine 77 (1999), S. 153-154 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ten diabetic renal transplant patients had porcine fetal islet-like cell clusters (ICC) injected intraportally or placed under the kidney capsule. In some patients, temporary graft survival was achieved, as evidenced by the urinary excretion of small amounts of porcine C-peptide (4 patients) and the identification of some intact insulin-staining cells in a biopsy specimen (1 patient). Glucose metabolism remained unaffected. To improve the results, better islets and better immunosuppressive protocols are required. We found that, while fetal porcine ICC produced insulin only after several weeks, adult islets gave immediate insulin production. The search for an optimal immunosuppression was conducted in the pig-to-rat islet transplant model. A clear inhibitory effect on the xenograft rejection was observed when using some of the new drugs. The best results were achieved with a triple drug regimen consisting of cyclosporine, mycophenolate mofetil and leflunomide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050325
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  • 4
    Electronic Resource
    Electronic Resource
    No viral disease after xenotransplantation (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 392 (1998), S. 646-646 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SirYou refer in your Briefing on xenotransplantation (Nature 391, 320–325; 1998) to a study on seroreactivity to porcine viruses in the ten diabetic patients transplanted with fetal pig islets in Stockholm, Sweden, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/33517
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  • 5
    Electronic Resource
    Electronic Resource
    Cyclosporine A in Fat Emulsion Carrier: Immunosuppressive Effect In Vitro (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 35 (1992), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have recently shown in a rut model that the acute decrease in glomerular filtration rate caused by intravenous Sandimmun® can be avoided if Cyclosporine A (CyA) is given in a fat emulsion carrier instead. The present study was undertaken to determine the immunosuppressive effect in vitro of this new formulation.The inhibitory effect on the lymphocyte responsiveness of CyA in fat emulsion carrier was compared with that of CyA dissolved in alcohol, using mitogens as well as alloantigens as stimuli. In the mixed lymphocyte culture and cell-mediated lympholysis tests and in the interleukin-2 assay, both formulations seemed equally effective. CyA in fat emulsion was somewhat less effective than CyA in alcohol in the mitogen tests. In clinical practice the fat emulsion would be rapidly metabolized, and to further evaluate our new formulation, studies in experimental Organ transplantation are needed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1992.tb02855.x
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  • 6
    Electronic Resource
    Electronic Resource
    Dissolving intravenous cyclosporin A in a fat emulsion carrier prevents acute renal side effects in the rat (1993)
    Springer
    Transplant international 6 (1993), S. 69-72 
    Details
    ISSN: 1432-2277
    Keywords: Cyclosporin A, carrier, in the rat ; Soybean oil, cyclosporin A ; Cremophore EL, cyclosporin A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cyclosporin A (CyA)-induced nephrotoxicity is still a serious clinical problem. The nephrotoxicity seems to be more pronounced when CyA (solubilized in water with Cremophore EL, as in Sandimmun) is given intravenously than when it is given orally. Using soybean oil in which CyA was dissolved, we prepared an intravenous fat emulsion without an artificial detergent, such as Cremophore EL. The renal effects of our new formula were compared with those of Sandimmun and Cremophore EL in a rat model. CyA in the fat emulsion did not significantly affect the glomerular filtration rate (GFR). Both Sandimmun and Cremophore EL significantly reduced the GFR. These results suggest that a change in the vehicle may obviate the acute nephrotoxic side effects caused by intravenous administration of CyA solubilized by Cremophore EL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336647
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  • 7
    Electronic Resource
    Electronic Resource
    Cyclosporin A in fat emulsion carriers: studies on the immunosuppressive potential, using the heterotopic heart transplant model in rats (1994)
    Springer
    Transplant international 7 (1994), S. 438-441 
    Details
    ISSN: 1432-2277
    Keywords: Cyclosporin A, fat emulsion ; Fat emulsion, CyA, heart transplantation ; Immunosuppression, CyA, fat emulsion ; Heart transplantation, rat, CyA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cyclosporin A (CyA) is an extremely lipophilic drug that needs a solubilizing agent to become soluble in water. In the commercially available intravenous formulation-Sandimmun-Cremophor EL is used for this purpose. It is likely that Cremophor EL contributes to some of the side effects produced by i. v. Sandimmun. We have recently shown that if Cremophor EL is replaced by a soybean oil (SBO)-based fat emulsion carrier, the acute renal side effects following i. v. administration of CyA are avoided in a rat model. It is then important to ascertain whether the use of a fat emulsion carrier alters the immunosuppressive effect of CyA. Moreover, fatty acids can themselves influence the immune system, and both omega-3 and omega-6 fatty acids have been reported to possess immunosuppressive properties. In the present study, the effect on graft survival of i. v. CyA administered in five different formulations, using fat emulsions or liposomes as carriers, was compared to that of conventional Sandimmun infusion substance in the heterotopic heart transplant model in rats. The new formulations tested did not reduce the immunosuppressive effect of CyA. On the contrary, a small but significant increase in graft survival was noted in the groups given CyA in the SBO-based fat emulsion carrier (17.0±0.82 days) and CyA in liposomes (16.0±0.63 days) as compared to the results in the Sandimmun-treated group (15.0±0.58 days: P〈0.01 and P〈0.05, respectively).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00346039
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  • 8
    Electronic Resource
    Electronic Resource
    Fibromuscular dysplasia in donor kidneys — experience with three cases (1989)
    Springer
    Transplant international 2 (1989), S. 228-231 
    Details
    ISSN: 1432-2277
    Keywords: Fibromuscular dysplasia in kidney transplantation ; Kidney transplantation, fibromuscular dysplasia ; Arterial stenosis in kidney transplantation, fibromuscular dysplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 1987, three patients received kidney grafts bearing medial fibroplasia at our hospital. Two of the grafts were from a cadaveric donor and one was from a living related donor kidney. The vascular affection was known before transplantation. Only one of the recipients developed stenosis and hypertension. With balloon catheter dilatation, the progressive stenosis of the renal graft artery could, however, be successfully corrected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02414540
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  • 9
    Electronic Resource
    Electronic Resource
    Non-specific reactivity in HIV antigen assay of sera from organ transplant recipients (1989)
    Springer
    Infection 17 (1989), S. 168-169 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01644020
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