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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacological Characterization of RJR-2403: A Nicotinic Agonist with Potential Therapeutic Benefit in the Treatment of Alzheimer's Disease (1997)
    Oxford, UK : Blackwell Publishing Ltd
    CNS drug reviews 3 (1997), S. 0 
    Details
    ISSN: 1527-3458
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1527-3458.1997.tb00331.x
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  • 2
    Electronic Resource
    Electronic Resource
    Efficacy of amlodipine in pediatric patients with hypertension (1999)
    Springer
    Pediatric nephrology 13 (1999), S. 304-310 
    Details
    ISSN: 1432-198X
    Keywords: Key words Amlodipine ; Hypertension ; Ambulatory blood pressure ; Quality of life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We designed a study to determine the efficacy and safety of amlodipine given once daily in the pediatric population. Twenty-one patients (mean age 13.1 years) with either essential (n=160) or renal (n=5) hypertension, and newly diagnosed (n=15) or poorly controlled or intolerant on existing antihypertensive therapy (n=6), were included. Patients received amlodipine once daily at a starting mean dose of 0.07±0.04 mg/kg per day. The total daily dose of amlodipine was increased 25%–50% every 5–7 days if the mean home blood pressure measurements (HBPM) were above the 95th percentile for age and gender. A baseline followed by a repeat 24-h ambulatory blood pressure monitor study (ABPM) was performed in 20 patients when the mean HBPM was below the 95th percentile goal. The mean titrated dose required to control BP was 0.29±0.11 mg/kg per day for those 〈13 years, 0.16±0.11 mg/kg per day for those ≥13 years, 0.23±0.14 mg/kg per day for essential, hypertension and 0.24±0.13 mg/kg per day for renal hypertension. The ABPM demonstrated that amlodipine provided effective BP control as primary therapy in 14 essential patients. Adverse effects included fatigue (n=6), headache (n=5), facial flushing (n=4), dizziness (n=3), edema (n=3), abdominal pain (n=3), chest pain (n=2), nausea (n=1), and vomiting (n=1). Quality of life appeared to improve during therapy. Amlodipine was an effective once daily antihypertensive agent with an acceptable safety profile. Higher doses of amlodipine were required for younger patients, and monotherapy was effective in patients with essential hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050614
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  • 3
    Electronic Resource
    Electronic Resource
    The X-ray/Gamma-ray Spectrometer on the Near Earth Asteroid Rendezvous Mission (1997)
    Springer
    Space science reviews 82 (1997), S. 169-216 
    Details
    ISSN: 1572-9672
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract An X-ray/gamma-ray spectrometer has been developed as part of a rendezvous mission with the near-Earth asteroid, 433 Eros, in an effort to answer fundamental questions about the nature and origin of asteroids and comets. During about 10 months of orbital operations commencing in early 1999, the X-ray/Gamma-ray Spectrometer will develop global maps of the elemental composition of the surface of Eros. The instrument remotely senses characteristic X-ray and gamma-ray emissions to determine composition. Solar excited X-ray fluorescence in the 1 to 10 keV range will be used to measure the surface abundances of Mg, Al, Si, Ca, Ti, and Fe with spatial resolutions down to 2 km. Gamma-ray emissions in the 0.1 to 10 MeV range will be used to measure cosmic-ray excited elements O, Si, Fe, H and naturally radioactive elements K, Th, U to surface depths on the order of 10 cm. The X-ray spectrometer consists of three gas-filled proportional counters with a collimated field of view of 5° and an energy resolution of 850 eV @ 5.9 keV. Two sunward looking X-ray detectors monitor the incident solar flux, one of which is the first flight of a new, miniature solid-state detector which achieves 600 eV resolution @ 5.9 keV. The gamma-ray spectrometer consists of a NaI(Tl) scintillator situated within a Bismuth Germanate (BGO) cup, which provides both active and passive shielding to confine the field of view and eliminate the need for a massive and costly boom. New coincidence techniques enable recovery of single and double escape events in the central detector. The NaI(Tl) and BGO detectors achieve energy resolutions of 8.7% and 14%, respectively @ 0.662 MeV. A data processing unit based on an RTX2010 microprocessor provides the spacecraft interface and produces 256-channel spectra for X-ray detectors and 1024-channel spectra for the raw, coincident, and anti-coincident gamma-ray modes. This paper presents a detailed overview of the X-ray/Gamma-ray Spectrometer and describes the science objectives, measurement objectives, instrument design, and shows some results from early in-flight data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005052720796
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  • 4
    Electronic Resource
    Electronic Resource
    Near Magnetic Field Investigation, Instrumentation, Spacecraft Magnetics and Data Access (1997)
    Springer
    Space science reviews 82 (1997), S. 255-281 
    Details
    ISSN: 1572-9672
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The primary objective of the investigation is the search for a body-wide magnetic field of the near Earth asteroid Eros. The Near Earth Asteroid Rendezvous (NEAR) 3-axis fluxgate magnetometer includes a sensor mounted on the high-gain antenna feed structure. The NEAR Magnetic Facility Instrument (MFI) is a joint hardware effort between GSFC and APL. The design and magnetics approach achieved by the NEAR MFI effort entailed low-cost, up-front attention to engineering solutions which did not impact the schedule. The goal of the magnetometer is reliable magnetic field measurements within 5 nT, which necessitates the use of an extensive spacecraft magnetic interference model but is achievable with the full year's orbital data set. Such a goal has been shown viable with recent in-flight calibration data and comparisons to the WIND magnetometer data. The NEAR MFI effort has succeeded in providing magnetic field measurements for the first flight in NASA's Discovery line.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005089829882
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    Paper (German National Licenses)
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