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  • 1
    Electronic Resource
    Electronic Resource
    Rat amylin mediates a pressor response in the anaesthetised rat: implications for the association between hypertension and diabetes mellitus (1997)
    Springer
    Diabetologia 40 (1997), S. 256-261 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Amylin ; hypertension ; calcitonin ; ACE inhibition ; calcitonin gene related peptide.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Amylin (or islet amyloid polypeptide) has been reported to have binding sites in the central nervous system and the kidney and has been shown to activate plasma renin. It has been postulated that this peptide may be an important mechanistic link between hypertension and diabetes in the insulin resistance syndrome. To explore this issue, the effects of rat amylin on mean arterial blood pressure were investigated in anaesthetised rats. Amylin elicited a pressor response of approximately 10 mmHg (maximal at 100 pmol · kg–1) which was apparent within 30–60 s and persisted over 15 min. At higher concentrations amylin elicited a hypotensive response (negative log IC50 8.52 mol · kg–1). The novel amylin receptor antagonist AC413 (12 nmol · kg–1· min–1) reduced the pressor response but not the hypotensive effects of amylin. The peptide antagonist calcitonin gene-related peptide (CGRP)8–37 (12 nmol · kg–1· min–1) reduced the pressor response elicited by amylin and also antagonized the hypotensive effect of amylin. Pre-treatment of animals with the ganglion blocker mecamylamine (3 mg · kg–1 s. c.) reduced the pressor effect of amylin. Following the administration of the angiotensin converting enzyme inhibitor ramiprilat (300 nmol · kg–1 i. v.) the pressor response to amylin was reduced. Salmon calcitonin also elevated blood pressure in the anaesthetised rat; doses of amylin and salmon calcitonin associated with a pressor effect were associated with increases in plasma renin activity. We conclude that amylin may act centrally to elevate blood pressure in the anaesthetised rat, possibly through activation of the renin angiotensin system. [Diabetologia (1997) 40: 256–261]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050672
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  • 2
    Electronic Resource
    Electronic Resource
    Simian Immunodeficiency Virus DNA Vaccine Trial in Macaques (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 772 (1995), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1995.tb44746.x
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  • 3
    Electronic Resource
    Electronic Resource
    Life history and population dynamics of the western mosquitofish: a comparison of natural and introduced populations (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 46 (1995), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Life history and population dynamic patterns of Gambusia affinis in southeastern Louisiana varied spatially and temporally in 1990 and 1991, but were consistent with previous reports of this species in the southern regions of its natural range. Several differences exist among populations in different geographic regions within the United States, as reported in the literature, which do not follow a‘ native v. introduced’ dichotomy: (1) brood size decreases and offspring size increases from north to south; (2) large overwintered females in northern areas produce more broods within a season than those in southern populations, while the reverse is true for young-of–year females; (3) minimum size at first reproduction follows a seasonal pattern within populations, but tends to be smaller in southern and larger in northern and Hawaiian populations; (4) synchronous reproduction early in the season is characteristic of northern populations, but does not occur in southern areas; and (5) mosquitofish reproduce year–round in Hawaii, while 'southern’ populations within the continental U.S. cease reproduction during winter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1995.tb01407.x
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  • 4
    Electronic Resource
    Electronic Resource
    Characterization of Alumina Scales Formed During Isothermal and Cyclic Oxidation of Plasma-Sprayed TBC Systems at 1150°C (1999)
    Springer
    Oxidation of metals 52 (1999), S. 31-76 
    Details
    ISSN: 1573-4889
    Keywords: SCALE FRACTURE ; OXIDE SCALES ; ALUMINA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The isothermal- and cyclic-oxidation behavior ofthermal barrier coating (TBC) systems consisting ofvacuum plasma-sprayed (VPS) Ni-22Cr-10Al-1Y (wt.%) bondcoatings and air plasma-sprayed (APS)Y2O3-stabilized ZrO2 (YSZ) top coatings (onsingle-crystal superalloys) was investigated. Themicrostructures, flaw contents, and fracture behavior ofthe Al2O3 scales formed duringoxidation testing at 1150°C were characterized (by analysis of coating andscale fracture surfaces and metallographic crosssections). Significant localized fracture and bucklingof the Al2O3 scales that formedalong the bond-coat-top-coat interfaces were observed after cyclic oxidationof TBCs. However, substantial amounts of localized scaledamage did not induce rapid TBC failure. Decohesion ofthe columnar alumina scales on the rough bond-coat surfaces occurred by both internalAl2O3 fracture (parallel to themetal surface) and oxide-metal delamination. There weremicrostructural indications ofAl2O3 scale crack healing bysintering into planar arrays of voids. Alumina scales that formed onconvex NiCrAlY surfaces (with radii of 50 μm or less)often contained significant amounts of internal voids(along grain boundaries) after cyclic oxidation, whereas scales formed by isothermal oxidationcontained few visible voids. Accelerated void growth inAl2O3 scales on the irregularNiCrAlY surfaces appeared to be creep-related and wasattributed to the synergistic effects of geometric and thermalstresses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018870923397
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  • 5
    Electronic Resource
    Electronic Resource
    Experimental infection of pigs with the newly identified swine hepatitis E virus (swine HEV), but not with human strains of HEV (1998)
    Springer
    Archives of virology 143 (1998), S. 1405-1415 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  A novel virus of pigs, swine hepatitis E virus (swine HEV), was recently identified and shown to be antigenically and genetically related to human HEV. In the present study, we attempted to infect specific-pathogen-free (SPF) pigs experimentally with swine HEV or with human strains of HEV. Serum samples collected from naturally infected pigs were used as the source of swine HEV. Pigs inoculated intravenously with serum samples containing swine HEV seroconverted to anti-HEV 4 to 8 weeks postinoculation, and the virus spread to an uninoculated pig. Swine HEV was detected in nasal and rectal swab materials as early as 2 weeks postinoculation and for 4 to 8 weeks thereafter. Viremia appeared 4 to 6 weeks postinoculation and lasted 1 to 3 weeks. The inoculated pigs appeared clinically normal and serum liver enzymes were not significantly elevated. In contrast, pigs were not infected when inoculated intravenously with about 105 monkey infectious doses of one of two human strains of HEV (Sar-55 or Mex-14).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007050050384
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of foliar supplements of potassium nitrate and urea on the yield of winter wheat (1995)
    Springer
    Nutrient cycling in agroecosystems 44 (1995), S. 217-223 
    Details
    ISSN: 1573-0867
    Keywords: foliar fertilizer ; nitrate ; potassium ; urea ; wheat ; yield
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Winter wheat crops were grown with ostensibly adequate supplies of all soil nutrients in 1990 and 1991 with the aim of testing if late foliar supplements of K and N, applied at key development stages, could improve grain yield and grain N content. Foliar sprays of KNO3 solution, supplying up to 40 kg K ha−1 in total, at flag leaf unfolded, inflorescence completed and the watery-ripe stage of grain filling, had no effect on yield, yield components or grain N. Urea, supplying 40 kg N ha−1 at flag leaf unfolded, had no effects on grain yield and grain N in 1990, but in 1991 grain N was increased by 0.14% whilst yield was reduced by up to 0.6 t ha−1. Urea scorched flag leaf tips in both years. In 1990, the spring was very dry and foliar supplements might have been expected to have had an effect, but on this highly fertile soil all crop K and N requirements were met from the soil.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00750928
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