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  • 1
    Electronic Resource
    Electronic Resource
    Antigen-stimulated lung CD4+ cells produce IL-5, while lymph node CD4+ cells produce Th2 cytokines concomitant with airway eosinophilia and hyperresponsiveness (1999)
    Springer
    Inflammation research 48 (1999), S. 602-612 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Th2 — Airway inflammation — Antigen — T cell — Cytokines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: We investigated whether airway inflammation in a mouse model of allergic asthma is related to antigen-specific T cell responses in the effector organ, the lung, and in the lung draining lymph nodes (LN). ¶Materials and Subjects: In BALB/c mice pathophysiological parameters were measured in vivo, and lung draining LN and lung cells were restimulated in vitro. ¶Treatment: Mice were sensitized with ovalbumin and repeatedly challenged with ovalbumin or saline inhalation. ¶Methods: Airway reactivity, inflammation in the airways, serum levels of IgE were measured, and cytokine levels and proliferative responses were determined in antigen-stimulated lymphocyte cultures. ¶Results and Conclusions: Sensitization results in antigen-specific Th0-like LN cells, despite the presence of antigen-specific IgE. Repeated antigen inhalation induced airway hyperresponsiveness and eosinophil infiltration concomitant with a shift towards Th2 cytokine production exclusively by lung draining LN T cells. Furthermore, these airway symptoms are associated with antigen-specific CD4+ effector T cells in the airway tissue producing only IL-5, but not IL-4, which are unable to proliferate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050510
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  • 2
    Electronic Resource
    Electronic Resource
    Does lowering of cholesterol levels influence functional properties of large arteries? (1995)
    Springer
    European journal of clinical pharmacology 48 (1995), S. 217-223 
    Details
    ISSN: 1432-1041
    Keywords: Hypercholesterolaemia ; HMG-CoA-reductase inhibitors ; Pravastatin ; vessel wall properties ; arterial distensibility ; arterial compliance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Hypercholesterolaemia is a risk factor for atherosclerosis and induces endothelial dysfunction. Endothelial dysfunction may increase vascular tone and arterial stiffness and as a consequence may decrease arterial distensibility (DC) and arterial compliance (CC). It is hypothesized that lipid-lowering therapy may enhance DC and CC. Therefore, the present study investigates the effect of lipid-lowering therapy with pravastatin on the haemodynamics, DC and CC of the elastic common carotid artery (CCA), and the muscular femoral (FA) and brachial (BA) arteries in patients with primary hypercholesterolaemia. After an 8-week placebo run-in period with a low-cholesterol diet, 19 patients with total cholesterol concentrations of between 6.5 and 9.0 mmol·l−1 and triglyceride concentrations 〈4 mmol·l−1 entered a double-blind placebo controlled crossover study. Patients received pravastatin 40 mg o.d. or placebo, each for 8 weeks. Throughout the study the lipid-lowering diet was continued. With pravastatin, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides were decreased (total cholesterol 26%, LDL-C 35%, triglycerides 16%), while high-density lipoprotein cholesterol (HDL-C) was not changed. Other laboratory values remained within the normal range. Blood pressure, heart rate, cardiac function and systemic vascular resistance were not influenced by pravastatin. Compared to placebo, diameter, distensibility and compliance of all arteries were not statistically significantly changed with pravastatin. These data suggest that, in patients with mild to moderate primary hypercholesterolaemia, short-term lowering of plasma cholesterol does not alter the haemodynamics and vessel wall properties of large arteries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198301
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacological properties of nebivolol in man (1997)
    Springer
    European journal of clinical pharmacology 51 (1997), S. 379-384 
    Details
    ISSN: 1432-1041
    Keywords: Key words Nebivolol ; β-adrenoceptor blockers ; β1-selectivity ; pharmacological properties
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objectives: The aims of the present study were to determine (1) the β1-blocking potency and (2) the β1-adrenoceptor selectivity of nebivolol in man after repeated dosing (7 days) compared with that after a single oral intake and with that after atenolol for 7 days. In addition, it was investigated whether (3) nebivolol has α1-blocking properties which might at least in part explain the vasodilating property of the compound. Methods: Twelve healthy subjects were randomized in an open, two-way cross-over study. β1-Blocking potency and β1-adrenoceptor selectivity of nebivolol 5 mg once daily (o.d.) were compared with those of atenolol at three doses (25, 50 and 100 mg) o.d. Measurements were performed after 1 and 7 days of drug intake. β1-Adrenoceptor potency was assessed by the percentage decrease in exercise-induced tachycardia (ΔEIT) during β-blockade. β1-Selectivity of nebivolol and atenolol were investigated using the heart rate response to isoprenaline at equipotent β1-blocking dosages of both drugs. α1-Blockade of nebivolol was measured using the phenylephrine dose-response test. Results: ΔEIT after a single oral dose of nebivolol 5 mg (10%) was significantly smaller than after nebivolol 5 mg o.d. for 7 days (15%). After 1 week of treatment no difference was seen in ΔEIT between nebivolol 5 mg o.d. and atenolol 25 mg o.d. (16%). At these dosages the suppression in isoprenaline-induced tachycardia by both drugs did not differ (CD20 ratio 1.7). In contrast to atenolol 25 mg, after 1 week of nebivolol 5 mg o.d., blood pressure decreased. This decrease averaged 10% and – like in a study with hypertensive patients – was similar with that after atenolol 100 mg o.d. None of the phenylephrine test parameters changed from pre-study values after nebivolol. Conclusions: β1-Blockade of nebivolol 5 mg is larger after repeated dosing than after a single oral intake. After once daily repeated dosing nebivolol 5 mg and atenolol 25 mg are equipotent in β1-antagonism. No difference in β1-selectivity is observed between the two drugs. Nebivolol has no additional α1-blocking property, which may at least in part explain its vasodilating effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050217
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    An unwanted side effect of hydroxyurea in a patient with idiopathic myelofibrosis (1995)
    Springer
    Annals of hematology 70 (1995), S. 279-280 
    Details
    ISSN: 1432-0584
    Keywords: Key words Hydroxyurea ; Idiopathic myelofibrosis ; Side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A patient with idiopathic myelofibrosis is reported who developed a drug fever after treatment with hydroxyurea, a generally effective and well-tolerated drug in chronic myeloproliferative syndromes. Typically, this form of fever develops after a few weeks of exposure to the drug and disappears with discontinuation of the drug. Possible interactions with prostaglandin or leukotriene metabolism may play a role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01784049
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    An unwanted side effect of hydroxyurea in a patient with idiopathic myelofibrosis (1995)
    Springer
    Annals of hematology 70 (1995), S. 279-280 
    Details
    ISSN: 1432-0584
    Keywords: Hydroxyurea ; Idiopathic myelofibrosis ; Side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A patient with idiopathic myelofibrosis is reported who developed a drug fever after treatment with hydroxyurea, a generally effective and well-tolerated drug in chronic myeloproliferative syndromes. Typically, this form of fever develops after a few weeks of exposure to the drug and disappears with discontinuation of the drug. Possible interactions with prostaglandin or leukotriene metabolism may play a role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01784049
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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