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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 254 (1997), S. 150-152 
    ISSN: 1434-4726
    Keywords: β2 integrins ; Otitis media ; Neutrophil migration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract β2 integrins are located on the surface of neutrophils and have important roles in cell migration to an inflammatory site. We investigated the inhibitory effect of antibodies to the β2 integrin family for neutrophil migration into middle ear effusion (MEE) during acute otitis media in children and chronic otitis media with effusion in both children and adults. Neutrophil migration to MEE samples was assessed in vitro in a 48-well Boyden chamber. The migration index value and the activity of chemo-attractants in MEE was found to be proportional to the number of infiltrated cells. Migration of activated neutrophils into MEE was significantly inhibited by blocking surface-expressed cell adhesion molecules (CAM) with anti-CD11b (Mac-1α) and anti-CD18 (common β2 subunit) antibodies (P 〈 0.001) but not with anti-CD11a (LFA-1α) antibody. These inhibitory effects of anti-CAM antibodies were found in all types of MEE in all age groups studied. A new therapeutic approach to inflammation has been considered recently that utilizes inhibition of neutrophil migration with a blocking antibody to CAM. Our in vitro data support a possible therapeutic effect of anti-CAM antibody, indicating that administration of anti-CD11b and CD18 antibodies may be useful for treating human otitis media.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Hyperfine interactions 118 (1999), S. 217-222 
    ISSN: 1572-9540
    Keywords: muonic molecule ; muon catalyzed fusion ; initial sticking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The initial αμ sticking probability, $$\omega _S^0 $$ , is revisited by a new sophisticated calculation which does not assume the three approximations taken usually in the literature calculations. It is found that magnitude of $$\omega _S^0 $$ increases very slightly by the removal of the approximations.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Hyperfine interactions 101-102 (1996), S. 325-328 
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract In order to investigate a discrepancy between existing literature values for the normalization constant in the asymptotic form of three-body wave functions for (dtµ)+, we report the results of a new calculation of the normalization constants for this system as well as the related system (ddµ)+. These were obtained by fitting to accurate variational wave functions with special care being taken to describe the long-range behavior.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Hyperfine interactions 101-102 (1996), S. 191-196 
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We calculated the (dµ) n=1 +t scattering in the energy region of the (dtµ)* resonant states below then=2 level of the tµ atom. From the cross sections, we estimated the resonant energies, widths and branching ratios. We found eleven resonant states with angular momentumJ=0, and some of their resonant energies relative to then=2 level of tµ are small enough to form the [(dtµ)* dee] by the Vesman mechanism. These resonant states decay to (dµ)[inn=1 +t or (tµ) n=1 + d scattering states. The total decay rates are about 1011 s−1 which is three orders of magnitude larger than the fusion rates of (dtµ)*→4 He + n+ 17.6 MeV + µ. The main part of the decaying channel from the shallow resonant states is the (dµ) n=1 +t channel. The branching ratios of the (dµ) n=1 +t decay channel are around 0.9. Most of the muons that reach to then=2 states of tµ can transfer to then=1 state of du through (tµ) n=2 + D2 → [(dtµ)*dee] and (dtµ)* → (dµ) n=1 +t processes.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Hyperfine interactions 101-102 (1996), S. 319-324 
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using the coupled rearrangement channel method, we have calculated resonance energies for meta-stable states of the molecular ion dtµ* associated with the adiabatic 3σ potential. The vacuum polarization effect was taken into account by direct inclusion of the Uehling potential in our three-body Hamiltonian. Comparing with the solution of the pure Coulombic Schrödinger equation a shift of approximately +0.1 eV is found. Thus the infinite series of states of the Coulombic Schrödinger equation becomes truncated. Eleven states remain semi-bound, five of them with binding energy smaller than the dissociation energy of the D2 molecule, facilitating formation of dtµ* in tµ(2s)-D2 scattering by means of the Vesman-mechanism.
    Type of Medium: Electronic Resource
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