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  • 1
    Electronic Resource
    Electronic Resource
    Photostimulated Luminescence in KCI〈sub〉x〈/sub〉Br〈sub〉1-x〈/sub〉: Eu Phosphor Ceramics for Two-Dimensional X-Ray Imaging Sensor (1996)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 239-241 (Nov. 1996), p. 303-306 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/02/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.239-241.303.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    T-Cell Receptor Diversity Expressed by CD4+ T Cells Activated by Primary Allogeneic HLA-DR Stimulation: Estimation of the Degree of CDR3 Diversity (1996)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 43 (1996), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In order to analyse the diversity of T-cell receptors (TCRs) expressed by the T-cell population activated by allogeneic HLA-DR stimulation, TCRβ cDNA was synthesized from mRNA of human CD4+ T cells that had been stimulated in a primary mixed lymphocyte reaction (MLR). The TCRβ cDNA was amplified by the polymerase chain reaction (PCR), subjected to bacterial cloning, and sequenced from Vβ through Jβ. Twenty-six different Vβ genes and 10 different Jβ segments were detected among 56 randomly selected cDNA clones. Occurrences of Vβ17.1 and Jβ1.5 were higher than those found in the CD4+ T-cell population activated with a CD3-specific antibody. A total of 53 different CDR3 sequences, two of them occurring more than once, were detected among the 56 cDNA clones. In order to estimate the degree of CDR3 diversity, amino acid similarity in the CDR3 region of the cDNA was calculated and compared with those of the anti-CD3-activated T-cell sequences as well as those of various published T-cell clone sequences, each directed to either alloantigens or single antigenic peptides. It was found that the similarity score among CDR3 sequences obtained from the MLR (56.4 ± 10.3) was comparable to those of anti-CD3-activated T cells (55.7 ± 10.7) and those of T-cell clones directed toward alloantigens (range, 48.4 ± 12.4−59.4 ± 13.1), but significantly smaller than those of T-cell clones directed toward single antigenic peptides such as those derived from myelin basic protein (75.6 ± 17.9) and cytochrome c (76.9 ± 20.5). These results provide quantitative proof that TCRs of T cells activated by primary allogeneic HLA-DR stimulation have a larger diversity than those recognizing single antigenic peptides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.1996.d01-67.x
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  • 3
    Electronic Resource
    Electronic Resource
    Granulocyte and monocyte apheresis suppresses symptoms of rheumatoid arthritis: a pilot study (1998)
    Springer
    Rheumatology international 18 (1998), S. 113-118 
    Details
    ISSN: 1437-160X
    Keywords: Key words Rheumatoid arthritis ; Granulocyte and monocyte apheresis ; Iliac bone marrow ; CD15+CD16 ; cells ; Joint counts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate if granulocyte and monocyte apheresis mitigates the symptoms of rheumatoid arthritis (RA), and influences production of panmyelocytes (CD15+ CD16– cells) at the bone marrow level, 27 RA patients who had elevated granulocyte counts were recruited. The granulocyte and monocyte apheresis column (G-1 column) is an extracorporeal type device packed with 220 g cellulose acetate beads to which granulocytes and monocytes specifically adhere. Patients received apheresis of 1 hr duration twice per week, 8 times over a period of 4 weeks. To prepare CD15+CD16– cells, iliac bone marrow aspirate was obtained at baseline and at 2 weeks after completion of the apheresis course. Ex-vivo proliferation of bone marrow low density cells and production of IgM-RF were also investigated. Following granulocyte and monocyte apheresis, there was a suppressed tendency in the number of CD15+CD16– cells in patients with high bone marrow CD15+CD16– cell counts at baseline. Clinical assessments 2 weeks after the completion of apheresis therapy showed improvements in swollen joint count (P〈0.001), tender joint count (P〈0.001) and duration of morning stiffness (P〈0.005). The results suggest that granulocytes and monocytes/macrophages have a pathological role in RA and apheresis treatment to reduce or suppress these cells should benefit patients with RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002960050068
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