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  • 1
    Electronic Resource
    Electronic Resource
    Serum lipoprotein(a) concentrations and apolipoprotein(a) phenotypes in the families of NIDDM patients (1995)
    Springer
    Diabetologia 38 (1995), S. 1434-1442 
    Details
    ISSN: 1432-0428
    Keywords: Apolipoprotein(a) ; diabetes mellitus ; family study ; lipids ; lipoprotein(a) ; lipoproteins ; phenotypes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the quantitative and qualitative characteristics of lipoprotein(a) [Lp(a)] as a function of apolipoprotein(a) [apo(a)] phenotype in 87 members (42 males, 45 females) of 20 diabetic families, 26 of whom were diagnosed with non-insulin-dependent diabetes mellitus (NIDDM) with moderate glycaemic control (HbA1c7.1±1.2%). Apo(a) phenotyping was performed by a sensitive, high-resolution technique using SDS-agarose/gradient PAGE (3–6%). To date, 26 different apo(a) phenotypes, including a null type, have been identified. Serum Lp(a) levels of NIDDM patients and non-diabetic members of the same family who had the same apo(a) phenotypes were compared, while case control subjects were chosen from high-Lp(a) non-diabetic and low-Lp(a) non-diabetic groups with the same apo(a) phenotypes in the same family. Serum Lp(a) levels were significantly higher in NIDDM patients than in non-diabetic subjects (39.8±33.3 vs 22.3±19.5 mg/dl, p〈0.05). The difference in the mean Lp(a) level between the diabetic and non-diabetic groups was significantly (p〈0.05) greater than that between the high-Lp(a) non-diabetic and low-Lp(a) non-diabetic groups. An analysis of covariance and a least square means comparison indicated that the regression line between serum Lp(a) levels [log Lp(a)] and apo(a) phenotypes in the diabetic patient group was significantly (p〈0.01) elevated for each apo(a) phenotype, compared to the regression line of the control group. These data, together with our previous findings that serum Lp(a) levels are genetically controlled by apo(a) phenotypes, suggest that Lp(a) levels in diabetic patients are not regulated by smaller apo(a) isoforms, and that serum Lp(a) levels are greater in diabetic patients than in non-diabetic family members, even when they share the same apo(a) phenotypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400604
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The usage of variable regions of the human T cell receptor in patients with IgA nephropathy (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 4 (1998), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1797.1998.tb00456.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of Indomethacin Administration on Bone Turnover and Bone Mass in Adjuvant-Induced Arthritis in Rats (1996)
    Springer
    Calcified tissue international 59 (1996), S. 385-391 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Bone formation rate — Osteoclast — Osteocalcin — Indomethacin — Histomorphometry.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. We examined the bone turnover and bone mass in adjuvant-induced arthritis in rats and assessed the effects of indomethacin in this model. One hundred ten SD rats, 6 weeks of age, were assigned to 11 groups and injected with adjuvant or solvent in the right foot. Adjuvant-injected rats were orally administered indomethacin at doses of 0 (vehicle), 0.1 (low), 0.5 (medium), and 1.5 (high) mg/kg body weight from the start (day 0). Animals were sacrificed on days 0, 14 (acute phase), and 28 (chronic phase). In the arthritic-control group, serum osteocalcin level and bone mineral content of the fourth lumbar body (L4) and the femur were significantly reduced on day 14. Serum alkaline-phosphatase was increased on day 28. Trabecular bone volume of L4 was decreased on day 14, and the value was further decreased on day 28. Bone formation rate (BFR/BS) was significantly reduced on day 14, and then osteoclast number (Oc.N/BS) increased on day 28. Indomethacin treatment dose-dependently prevented increases in paw volume and osteoclast number. In the high dose group, these indices were maintained at the same level with those in the normal group. However, indomethacin treatments were not able to maintain the parameters of bone formation such as serum osteocalcin and BFR/BS values, and the trabecular bone mass decrease was only partially prevented. These data clearly indicated both reduced bone formation and increased bone resorption as the causes of bone loss in adjuvant-induced arthritis in rats. Increased bone resorption seemed to be due to the increased activity of prostaglandins, but bone formation defect would be related to other factors in this animal model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900144
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Ultrastructure and ion permeability of the two types of epithelial cell arranged alternately in the gill of the fresh water branchiopod Caenestheriella gifuensis (Crustacea) (1997)
    Springer
    Zoomorphology 117 (1997), S. 53-62 
    Details
    ISSN: 1432-234X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  The adult freshwater branchiopod, Caenestheriella gifuensis, has, as respiratory organs, fifteen pairs of slender cone-shaped gills composed of a thick epithelium. The silver nitrate/nitric acid technique revealed that the gill epithelium consisted of two kinds of cell, types I and II, which were alternately arranged with irregular interdigitations to form a unique, daisy pattern. Only type I cells were darkly stained by this technique, indicating high permeability of these cells to chloride ions and appearing to be responsible for the ion transport and osmoregulation. Further, electron microscopy disclosed fine structural characteristics of the two distinct types of epithelial cell covered by an extremely thin and soft cuticle layer, suggesting high permeability to gases and ions. The type I epithelial cell was characterized by an abundance of mitochondria, well-developed infoldings of the basal cell membrane exceeding two-thirds of the epithelial thickness, (which produce a magnification of the basolateral surface area of the cell), sparse microvillous projections of the apical border, and complicated interdigitations with the other type of epithelial cell. In the type II epithelial cell, on the other hand, these characteristics were less developed. These results suggest that in addition to their respiratory function, type I epithelial cells are of the ion-transporting type and play an important role in the active absorption of electrolytes to maintain a constant osmotic pressure of the hemolymph in extremely salt-deficient, freshwater environments. The type II epithelial cells may function mostly as respiratory epithelial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004350050030
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Dominantly inherited leukodystrophy showing cerebellar deficits and spastic paraparesis: a new entity? (1997)
    Springer
    Journal of neurology 244 (1997), S. 446-449 
    Details
    ISSN: 1432-1459
    Keywords: Key words Hereditary spastic ; paraparesis ; White-matter disease ; Dominant inheritance ; Leukodystrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied a dominant hereditary disorder showing progressive spastic paraparesis. The symptoms began in early childhood, with cerebellar deficits and mild mental deterioration, and the subsequent appearance of limb spasticity resulted in severe disability in the 3rd-4th decades of life. None of the patients were associated with any somatic abnormalities. Brain MRI showed diffuse white-matter involevement in all affected patients, but not in unaffected siblings. Although dominant, recessive, or X-linked leukodystrophies cause similar clinical features, our family did not show any known biochemical or gene deficits characteristic of these disorders. The clinical, radiological, and biochemical findings of this family are reported and suggest a possible novel genetic disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050120
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Influence of cold-rolling and annealing conditions on formability of aluminium alloy sheet (1995)
    Springer
    Journal of materials science 30 (1995), S. 957-963 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Using an Al-Mg-Cu alloy developed for auto body panels, strip sheets are experimentally produced by various cold-rolling and annealing procedures. Tensile and metallographic properties of the sheets and their relations are examined to attain high formability. The elongation is closely related to the grain size, and increases with the final annealing temperature. The rolling texture influences the plastic anisotropy, the Lankford value of the sheets. The comparatively high Lankford values are obtained under the condition that both the intermediate and the final annealing temperatures are higher and the reduction ratio after the intermediate annealing is smaller.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01178430
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