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  • 1
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Skinresurfacing ; Laser-Faltenbehandlung ; Er:YAG-Laser ; CO2-Laser ; Scanner ; Key words Laser skin resurfacing ; Er:YAG laser ; CO2 laser ; Flashscanner
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We compared a cw carbon dioxide flash-scanning laser system to an Er:YAG laser in laser skin resurfacing of facial rhytides. In all patients, CO2 laser treatment showed a better cosmetic result whereas erythema and postinflammatory hyperpigmentation were less marked in Er:YAG laser therapy.
    Notes: Zusammenfassung Anhand einer klinischen Studie vergleichen wir einen cw-CO2-Laser mit Scannersystem mit einem Er:YAG-Laser hinsichtlich Wirksamkeit und Nebenwirkungsspektrum bei der Laser-Faltenbehandlung. Bei sämtlichen behandelten Patienten zeigte sich der CO2-Laser bezüglich des kosmetischen Endergebnisses dem Er:YAG-Laser deutlich überlegen. Erythem und postinflammatorische Hyperpigmentierung als in jedem Fall reversible Nebenwirkungen waren beim Er:YAG-Laser dagegen deutlich geringer ausgeprägt als beim CO2-Laser.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 141 (1999), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford BSL : Blackwell Science Ltd
    British journal of dermatology 140 (1999), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We describe a 65-year-old woman who had had wart-like lesions on the hands, lower arms and forehead for about 45 years. She had already had several basal cell carcinomas excised. Histological study, electron microscopy and in situ hybridization [human papilloma virus (HPV)-types 5/8/12/14/19–23/25/36] of skin biopsies confirmed a diagnosis of epidermodysplasia verruciformis (EV). Photodynamic therapy (PDT) was performed using a 20% 5-aminolaevulinic acid ointment applied for 6 h to the lesions and irradiating using an incoherent light source (λ = 580–740 nm, 160 mW/cm2, 160 J/cm2). Following PDT, blistering and crusting of the lesions occurred, but these healed completely within 2–3 weeks without scarring, and the cosmetic result was excellent. Six months after PDT a skin biopsy was taken. In situ hybridization was positive for HPV type 8 in skin which was clinically and histologically normal. Twelve months after PDT a few lesions had recurred on the hands. Although permanent cure of EV cannot be achieved by any therapy at present and single lesions continue to appear in this patient, topical PDT might result in better control of HPV-induced lesions.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 137 (1997), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Wells’ syndrome, or eosinophilic cellulitis, is characterized by recurrent cutaneous swellings which resemble acute bacterial cellulitis, and by distinctive histopathological changes. Skin lesions show dermal eosinophilic infiltration and the characteristic‘flame figures, which are composed of eosinophil major protein deposited on collagen bundles. The idiopathic hypereosinophilic syndrome is a multisystem disease with a high mortality rate. It is characterized by peripheral blood eosinophilia and eosinophilic infiltration of many organs, including the skin. The most common skin lesions are pruritic maculopapules and nodules over the trunk and limbs, with urticaria and angio-oedema. In contrast to Wells’ syndrome, the pathology of these skin lesions is non-specific with variable eosinophil infiltration. We report overlapping clinical and histopathological findings characteristic of both syndromes in one patient. Our data favour the hypothesis that both syndromes represent an abnormal eosinophilic response to a variety of underlying diseases or causative agents and thus are different expressions of one disease entity linked to theimmunobiology of eosinophils.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 133 (1995), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a child with scalp aplasia cutis congenita, whose mother was treated with methimazole during pregnancy. The relationship between antithyroid drug administration during pregnancy and the occurrence of scalp defects is discussed, and the pertinent literature is reviewed.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 133 (1995), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary We report three patients with severe, localized scleroderma, and with elevated titres of antinuclear antibodies, who were treated by plasmapheresis in combination with systemic steroid therapy. The therapeutic effectiveness of plasmapheresis was assessed on the basis of improvement in cutaneous and joint lesions. In all cases, significant improvement occurred after 2 months of therapy. Thus, in addition to treating systemic sclerosis, plasmapheresis can also be recommended for treatment of severe cases of localized scleroderma with elevated titres of antinuclear antibodies and antibodies to ss-DNA.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 133 (1995), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A total of 37 haemangiomas were treated in 28 patients by means of the flashlamp-pumped pulsed dye laser (FPDL). Twenty-nine haemangiomas were classified as superficial, and eight as mixed type. With FPDL treatment, excellent or good results were obtained in nearly 60% of superficial haemangiomas and 40% of mixed haemangiomas. In three of four patients with mixed type haemangiomas good results were obtained by means of Nd: YAG laser irradiation. In two patients, small superficial haemangiomas were removed by argon laser coagulation or CO2 laser vaporization, respectively.These results indicate that many children benefit from laser therapy of haemangiomas. Side-effects were rare.The FPDL is the treatment modality of choice for superficial haemangiomas. and the Nd: YAG laser for thicker lesions. Based on our results and the results reported in the literature, early laser therapy of childhood haemangiomas can be recommended.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The flashlamp-pumped pulsed dye laser (FPDL) was the first laser system specifically developed for the treatment of cutaneous vascular lesions such as port-wine stains (PWS), tckmgiectases and haemangiomas. Its theoretical advantages have been verified by numerous excellent clinical resultsAs there are few systematic studies on the adverse effects of this laser system, we investigated 100 consecutive patients who received FPDL therapy of PWS. Pain during and after laser therapy was a common complaint. Post-treatment erythema occurred in 29%. oedema in 73%. formation of hullae in 1%, and serous crusting in 46–83% of patients (based on our observations and the patients histories, respectively), all of which lasted for a maximum of 7 days. Furthermore, complications such as impetigo-like crusting occurred in 25%, bleeding in 12%. a pyogenic granuloma in 1%. hyperpigmentation in 27%, hypopigmentation in 1%, atrophic scarring in 3%, and an liypertrophic scar in 1%. Although most of these changes were only focal, and were predominantly transient, our results indicate that the incidence of side-effects and complications produced by the FPDI. (wavelength 585 nm, pulsewidth 450μs) may be higher than previously documented in the literature.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The maximum tumour thickness is the most important prognostic factor in malignant melanomas of the skin. However, the clinical outcome of thick nodular melanomas remains unpredictable. Therefore, we investigated possible prognostic markers in this subset of melanomas. From a melanoma data base, 12 patients with thick (〉 3 mm) stage I nodular melanomas of the skin were identified, who were still without signs of progression after five years of follow-up. These tumours were compared to a randomly selected series of 12 cases, who did not survive the first five years after removal of the tumours. We performed immunostaining for the p53-protein and the proliferation associated Ki-67-antigen. For quantification of immunostaining the tumours were entirely scanned. In addition, all tumours were investigated for any differences with conventionally applied prognostic features: the tumour thickness; the level of invasion; the prognostic index (tumour thickness multiplied by mitotic count); and the mean volume-weighted mean nuclear volume. We demonstrated significant differences between survivors and non-survivors exclusively in respect of the staining-indices for p53 and Ki-67 (P 〈 0.03 and 0.02, respectively). With both antibodies the tumours of survivors showed lower counts as compared to non-survivors. However, within both groups we found no significant correlations between the p53- and Ki-67-staining results. We conclude that immunostaining for p53-protein and Ki-67-antigen is helpful to identify individuals with thick nodular melanomas who are at risk of metastatic disease.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Gütegeschalteter Rubinlaser ; Tätowierungen ; Lentigines ; Key words Q-switched ruby laser ; Tattoos ; Lentigines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The Q-switched ruby laser (QSRL) with its wavelength of 694 nm and a pulse duration of around 40 nsec is an effective modality for the removal of tattoos and cutaneous pigmented lesions. Based on the principle of selective photothermolysis, selective damage to cutaneous pigment or pigmented cells is possible, allowing the scar-free elimination of endogenous or exogenous pigment in the skin. Main indications for the treatment with the QSRL are tattoos (amateur, professional, accidental, or cosmetic) and lentigines but the QSRL can also be used for lightening or even removing other pigmented lesions such as nevus spilus or café au lait macules. Furthermore, pigmented lesions of mucous membranes can be removed easily. Since treatment results in postinflammatory hyperpigmentation, melasma, and Becker’ nevus have proven to be inconsistent, the QSRL cannot be routinely recommended for these lesions. Melanocytic lesions are generally not treated, with the exception of nevus of Ota and nevus of Ito where there exacts a lack of therapeutic alternatives. Non-pigmented cells, which exist in nearly all melanocytic lesions, do not absorb the light of the QSRL and, therefore, do not react to this particular treatment. No information is available on the risk of partially damaged cells to become malignant after QSRL treatment. The QSRL is an excellent therapy for the removal of endogenous and exogenous pigment because of both the excellent treatment results and the lack of side effects, which are limited to transient hypo- and hyperpigmentation. The QSRL has accurred a wide range of applications within the field of dermatology.
    Notes: Zusammenfassung Der gütegeschaltete Rubinlaser mit einer Wellenlänge von 694 nm und einer Impulszeit im Nanosekundenbereich stellt eine effektive Behandlungsmöglichkeit für Tätowierungen und kutane pigmentierte Hautveränderungen dar. Aufgrund der selektiven Photothermolyse, dem Wirkungsprinzip des Rubinlasers, ist eine selektive Schädigung der Pigmentpartikel bzw. der pigmenttragenden Zellen in der Dermis möglich. Dadurch ist eine narbenfreie Entfernung von endogenem und exogenem Pigment möglich. Wichtige und häufige Indikationen für die Anwendung des gütegeschalteten Rubinlasers sind Tätowierungen (Amateur- und Profitätowierungen, Schmutztätowierungen, Permanent-Make-Up) und Lentigines solares. Der Rubinlaser eignet sich auch zur Behandlung weiterer pigmentierter Hautveränderungen wie Naevus spilus oder Cafe-au-lait-Flecken. Auch Veränderungen der Mundschleimhaut und der Lippen (Lentigines) können mit dem Rubinlaser problemlos entfernt werden. Da die Behandlung von postinflammatorischen Hyperpigmentierungen, Chloasma/Melasma und Becker-Nävi unterschiedliche Ergebnisse aufweist, ist der gütegeschaltete Rubinlaser für diese Indikationen nur eingeschränkt zu empfehlen. Prinzipiell ist von der Behandlung melanozytärer Hautveränderungen mit dem Rubinlaser abzuraten. Ausnahmen bilden der Nävus Ota sowie der Nävus Ito, da hier keine anderen Therapiemodalitäten zur Verfügung stehen. Nichtpigmentierte Zellen, die in fast allen melanozytären Hautveränderungen vorhanden sind, absorbieren das Rubinlaserlicht nicht und sind somit der Behandlung nicht zugänglich. Ob partiell geschädigte Zellen nach Rubinlaserbehandlung möglicherweise ein größeres Entartungsrisiko besitzen, ist nicht bekannt. Bei richtiger Indikationsstellung ist der gütegeschaltete Rubinlaser eine hervorragende Behandlungsmethode zur Entfernung von endogenem und exogenem Pigment der Haut. Aufgrund der Behandlungserfolge und der im Vergleich zu anderen Therapiemöglichkeiten geringen Nebenwirkungen, die sich auf eine transiente Hyper- oder Hypopigmentierung beschränken, hat der Rubinlaser sicher ein festes Anwendungsspektrum in der Dermatotherapie.
    Type of Medium: Electronic Resource
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