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Multidimensional Assessment of Chronic Low Back Pain: Predicting Treatment Outcomes (1997)

Strategier, Leslie D. ; Chwalisz, Kathleen ; Altmaier, Elizabeth M. ; [et al.]

Springer

Journal of clinical psychology in medical settings 4 (1997), S. 91-110

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ISSN: 1573-3572

Keywords: chronic pain ; low back pain ; treatment ; patient type ; physical improvement

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract This study explored responses of chronic low back pain patients to treatment for different types of patients (“dysfunctional,” “interpersonally distressed,” and “minimizer/adaptive coper”), as classified using the Multidimensional Pain Inventory (MPI). In addition, changes in MPI scores during treatment were examined separately for each patient type. Finally, this study explored the relationships between changes in MPI scores and physical improvement. Between-group differences in improvement were significant, with “dysfunctional” patients showing the most improvement on several scales. MPI scales that best predicted physical improvement differed according to patient type. Implications for treatment of low back pain patients are suggested, based upon differential reactions to treatment and different predictors of physical improvement for each patient group.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1026288205401

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Triple-Helix Formation by Pyrimidine Oligonucleotides Containing Nonnatural Nucleosides with Extended Aromatic Nucleobases: Intercalation from the major groove as a method for recognizing C·G and T · A base pairs (1997)

Lehmann, Thomas E. ; Greenberg, William A. ; Liberles, David A. ; [et al.]

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 80 (1997), S. 2002-2022

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ISSN: 0018-019X

Keywords: Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The sequence-specific recognition of double-helical DNA by oligonucleotide-directed triple helix formation is limited primarily to purine tracts. To identify potential lead compounds which are able to extend the sequence repertoire of triple helical complexes, we designed two carbocyclic nucleosides with nucleobases attached via amide bonds. N5-[(1R, 2S, 3R, 4R)-3-hydroxy-4-(hydroxymethyl)-2-methoxycyclopentyl]-2-{[(1H-pyrrol-2-yl)carbonyl]-amino}thiazole-5-carboxamide (L1) and 2-benzamido-N5-[(1R, 2S, 3R, 4R)-3-hydroxy-4-(hydroxymethyl)-2-methoxycyclopentyl]thiazole-5-carboxamide (L2) were synthesized and incorporated into pyrimidine oligonucleotides. The 2-(trimethylsilyl)ethoxymethyl (SEM) protecting group for the 1H-pyrrole NH was found to be compatible with DNA solid-phase synthesis of pyrimidine Oligonucleotides. By quantitative DNase I footprinting analysis, both nonnatural nucleosides L1 and L2 showed preferential binding of pyrimidine over purine bases: L1/2·(C·G) ≈ L1/2·(T · A) 〉 L1/2·(G·C) ≈ L1/2·(A · T). Comparison with the previously reported nonnatural nucleosides with extended aromatic nucleobases 1-(2-deoxy-β-D-ribofuranosyl)-4-(3-benzamidophenyl)-imidazole (D3) and N4-[6-(benzamido)pyridin-2-yl]-2′-deoxycytidine (bzM) suggests that the observed binding selectivity C · G ≈ T · A 〉 G · C ≈ A · T for the nucleoside analogs L1, L2, D3, and bzM is derived from sequence-specific intercalation with preferential stacking of their nucleobases over pyrimidine · purine Watson-Crick base pairs.

Additional Material: 6 Ill.