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  • 1
    Electronic Resource
    Electronic Resource
    Magnetic parameter control for high-density quadrivalued MO recording (invited) (abstract) : The 40th annual conference on magnetism and magnetic materials (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 5686-5686 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: To increase recording density of MO media, several schemes have been proposed. Among them, magnetic multivalued (MMV) recording is one of the most promising methods. We have first realized the quadrivalued MMV media using a field modulation method. Such media is composed of an exchange coupled TbFeCo/PtCo bilayer. By switching the external field in four levels, the separated signal corresponding to the each field is obtained as a four leveled output. For the acutal device application for high-density and high-speed recording, it is necessary to reduce the external field as small as possible. In the previous experiment, about ±900 Oe was necessary to record the whole levels. For such MMV media, the quadrivalued signal response depends on the magnetic characteristics of the TbFeCo/PtCo bilayer, which is so called dual write state. The higher field level on the MMV media is defined by the threshold field of the dual write state. It is found that the threshold field is controllable to tune the magnetic parameter, especially the exchange coupling force between the TbFeCo and PtCo. As a result, the reduction of the recording field less than 350 Oe is realized on a new media. Using such tuned media, high-density quadrivalued recording is experimentally carried out. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.362217
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  • 2
    Electronic Resource
    Electronic Resource
    Clinical implications of mRNA expression of KAI1 in ovarian cancer with or without metastasis (1999)
    Springer
    International journal of clinical oncology 4 (1999), S. 343-347 
    Details
    ISSN: 1437-7772
    Keywords: Key words KAI1, Ovarian tumors ; PCR ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. KAI1 is a potential metastasis suppressor gene for prostate cancer. Decreased expression of KAI1 mRNA has been shown to be associated with the formation of metastasis and the progression of prostate, lung, breast, pancreatic, and bladder cancer. It has also been reported, however, that KAI1 expression is unchanged in metastatic and nonmetastatic esophageal and gastric cancer. We performed the present study to investigate the function of KAI1 in the progression and/or metastasis of ovarian cancer. Methods. We investigated the mRNA expression levels of the KAI1 gene, using quantitative polymerase chain reaction (PCR), in 29 ovarian tumors (1 adenoma, 2 low- malignant potential tumors, 9 adenocarcinomas without metastasis, and 17 adenocarcinomas with metastasis), seven ovarian cancer cell lines, and two normal ovaries. Using a thermal cycler, we found that the KAI1 gene was amplified in parallel with an internal control gene, β-Actin. The relative expression ratio (KAI1/β-Actin) as measured by densitometry was used to evaluate gene expression. Immunohistochemical localization of the KAI1 protein in ovarian cancer tissues was confirmed by the avidin-biotin peroxidase complex (ABC) method. Results. The mRNA expression levels of KAI1 were consistent in normal ovary, ovarian tumor samples, and ovarian cancer cell lines. No statistically significant difference in the KAI1 mRNA expression level was found in ovarian cancer samples with or without metastasis. Immunohistochemistry revealed that the KAI1 protein was expressed in the cell membranes of ovarian cancer cells. Conclusions. Our results suggest that reductions in KAI1 mRNA expression are not involved in either the progression or metastasis of ovarian carcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101470050082
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  • 3
    Electronic Resource
    Electronic Resource
    Vapor condensation behind a shock wave propagating through a large molecular-mass medium (1996)
    Springer
    Shock waves 5 (1996), S. 287-292 
    Details
    ISSN: 1432-2153
    Keywords: Dual-step pressurization ; Film condensation ; Retrograde fluid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics , Technology
    Notes: Abstract Measurements of film condensation were made behind the incident shock wave propagating through a vapor-liquid two-phase medium. Major objective of the study is to identify condensing heat transfer rates of the vapor to the shock-tube side wall as well as to learn the condensing main flow field. Ethanol and E-10 (a heavy liquid named Afluid by the manufacturer) were extensively used as working fluid. Steady accumulation of the condensing vapor was confirmed on the wall surface, as similarly seen in the end-wall experiment conducted elsewhere. A most significant result is that “dual-step” shock pressurization was observed in E-10. The first pressure rise is a normal one created by an incident shock front, whereas the second pressure rise is taken place by some large disturbance in the main flow. The reason for this is not certain yet, but is speculated to be a long relaxation time or inefficient compressibility of the fluid. The visualized shock front and its vicinity of E-10 is completely different from those of normal gases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02425221
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  • 4
    Electronic Resource
    Electronic Resource
    Vapor condensation behind a shock wave propagating through a large molecular-mass medium (1996)
    Springer
    Shock waves 5 (1996), S. 287-292 
    Details
    ISSN: 1432-2153
    Keywords: Key words: Dual-step pressurization, Film condensation, Retrograde fluid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics , Technology
    Notes: Abstract. Measurements of film condensation were made behind the incident shock wave propagating through a vapor-liquid two-phase medium. Major objective of the study is to identify condensing heat transfer rates of the vapor to the shock-tube side wall as well as to learn the condensing main flow field. Ethanol and E-10 (a heavy liquid named Afluid by the manufacturer) were extensively used as working fluid. Steady accumulation of the condensing vapor was confirmed on the wall surface, as similarly seen in the end-wall experiment conducted elsewhere. A most significant result is that "dual-step" shock pressurization was observed in E-10. The first pressure rise is a normal one created by an incident shock front, whereas the second pressure rise is taken place by some large disturbance in the main flow. The reason for this is not certain yet, but is speculated to be a long relaxation time or inefficient compressibility of the fluid. The visualized shock front and its vicinity of E-10 is completely different from those of normal gases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00003873
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  • 5
    Electronic Resource
    Electronic Resource
    BMP-Induced osteogenesis on the surface of hydroxyapatite with geometrically feasible and nonfeasible structures: Topology of osteogenesis (1998)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 39 (1998), S. 190-199 
    Details
    ISSN: 0021-9304
    Keywords: BMP ; geometry ; carriers ; hydroxyapatite ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Bone morphogenetic protein (BMP) is known to require a suitable carrier to induce ectopic bone formation in vivo. Hydroxyapatite ceramics have been reported to be effective in some forms but ineffective in others as a carrier of BMP-induced bone formation. In this study we compare three geometrically different forms of hydroxyapatite to examine their functions as carriers of BMP-induced bone formation. A fraction containing all the active BMPs (BMP cocktail) was partially purified from a 4M guanidine extract from bovine bone by a three-step chromatographic procedure. The BMP cocktail was combined with each of three forms of hydroxyapatite - solid particles (SPHAP), porous particles (PPHAP), and coral-replicated porous tablets (coral-HAP) - and implanted subcutaneously into rats. Both the PPHAP and coral-HAP systems induced osteogenesis 2 weeks after implantation, as evidenced by morphological and biochemical observations. Details of the osteogenetic process were followed by double-fluorescence labeling in the coral-HAP system to confirm bone formation on the surface of hydroxyapatite. However, there was no evidence of osteogenesis or chondrogenesis in the SPHAP system. The results indicate that the geometry of the interconnected porous structure in PPHAP and coral-HAP create spaces for vasculature that lead to osteogenesis while the smooth structure and close contact of particles in SPHAP inhibit vascular formation and proliferation of mesenchymal cells, preventing bone and cartilage formation. It was concluded that the geometrical structure in hydroxyapatite ceramics that induces vasculature is crucial as a carrier for BMP-induced bone formation. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 39, 190-199, 1998.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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