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  • 1
    Electronic Resource
    Electronic Resource
    Phylogenetic relationships among species of Calyptogena (Bivalvia: Vesicomyidae) collected around Japan revealed by nucleotide sequences of mitochondrial genes (1995)
    Springer
    Marine biology 122 (1995), S. 401-407 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Phylogenetic relationships among the seven species of deep-sea giant clams Calyptogena (Bivalvia: Vesicomyidae) collected around Japan were examined using parts of nucleotide sequences of mitochondrial genes for cytochrome oxidase I (COI) and cytochrome oxidase III (COIII) and the encoded amino acid sequences. The seven species were C. soyoae (Sagami Bay), C. fausta (Suruga Bay), C. kaikoi (Nankai Trough), C. nautilei (Nankai Trough), C. phaseoliformis (Japan Trench), C. solidissima (Minami-Ensei Knoll, Okinawa Trough) and Calyptogena sp. (Iheya Ridge, Okinawa Trough). A clear phylogenetic split was observed between one group of three species (C. kaikoi, C. phaseoliformis and C. fausta) and the remaining species. This clustering corresponds to the two previously described subgenera within the genus Calyptogena (Calyptogean and Ectenagena) with the exception of the placement of C. nautilei, which had been placed in the subgenus Ectenagena. Genetic distances between two haplotypes of C. soyoae were 0.043 for the COI region and 0.055 for the COIII region, and three amino acid substitutions were detected with the COIII region. Calyptogena sp. from the Iheya Ridge could be distinguished from one of the two haplotypes (type A) of C. soyoae by only a single nucleotide substitution, a result that suggests that Calyptogena sp. of the Iheya Ridge diverged from C. soyoae after the two haplotypes had diverged, and it is now isolated from C. soyoae in Sagami Bay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00350872
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  • 2
    Electronic Resource
    Electronic Resource
    Seasonal variation in reproduction and population structure of the bivalve Limopsis tajimae in the upper bathyal zone of Suruga Bay, Japan (1998)
    Springer
    Marine biology 132 (1998), S. 471-481 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Seasonal variation in reproduction and population size structure was investigated for the suspension-feeding bivalve Limopsis tajimae Sowerby inhabiting the upper bathyal zone (300 m deep) of Suruga Bay, central Japan. The bivalve was collected at 1- to 4-month intervals for a period of 22 months, and bottom environment was monitored concurrently to detect factors affecting seasonality in the bivalve. Bottom water temperature, organic carbon and nitrogen contents in the sediments did not exhibit seasonal variation. Size-adjusted soft-tissue weight varied slightly, but statistically significantly between stations and months. However, its seasonal pattern was not obvious, and the pattern of temporal variation was totally different between stations. The sex ratio did not deviate from 1:1, and there was no significant difference between shell lengths of females and males. Females possess both immature small oocytes and large developed oocytes in their ovaries throughout the year, suggesting that they can potentially undergo year-round continuous reproduction. The proportion of developed oocytes in each female varied greatly from month to month, although no seasonal cycle was obvious. Population size structure of L. tajimae was polymodal. A mode of the smallest size class occurred in most months, suggesting long periods of bivalve recruitment. These findings indicate that seasonal variation in reproduction of the bivalve was negligible, probably reflecting constant physical and nutritive conditions of the bottom environment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002270050413
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular phylogeny of vestimentiferans collected around Japan, revealed by the nucleotide sequences of mitochondrial DNA (1997)
    Springer
    Marine biology 127 (1997), S. 507-513 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The phylogenetic relationships among local populations of undescribed vestimentiferan species that belong to the genera Lamellibrachia and Escarpia and had been collected at six sites around Japan were analyzed on the basis of the partial (1023 bp) nucleotide sequences of the mitochondrial gene for cytochrome oxidase I (COI), using a pogonophoran and a polychaete as outgroups. The identical amino acid sequence was deduced from the nucleotide sequence obtained from each of the vestimentiferans analyzed. The strong similarity among deduced amino acid sequences of COI suggested a close relationship between vestimentiferans and pogonophorans. On the basis of the phylogenetic relationships, the analyzed vestimentiferan populations were classified tentatively as five species. The genetic differentiation of vestimentiferans was suggested to occur bathymetrically as well as being a consequence of horizontal segregation. Two of these tentatively identified species inhabit both a hydrothermal area and a cold seep area, as is the case for some species of bivalves that belong to the genera Bathymodiolus and Calyptogena.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002270050039
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  • 4
    Electronic Resource
    Electronic Resource
    Possible mechanism to induce protein kinase C-dependent arterial smooth muscle contraction after subarachnoid haemorrhage (1995)
    Springer
    Acta neurochirurgica 137 (1995), S. 217-225 
    Details
    ISSN: 0942-0940
    Keywords: Subarachnoid haemorrhage ; vasospasm ; 12-hydroxyeicosatetraeonic acid (12-HETE) ; 1,2-diacylglycerol (DAG) ; protein kinase C (PKC)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A possible mechanism for the induction of protein kinase C (PKC)-dependent vascular contraction independent to the increase of intracellular Ca++ was investigated in the pathogenesis of cerebral vasospasm in the double subarachnoid haemorrhage (SAH) model. The level of 1,2-diacylglycerol (DAG), which is an intrinsic PKC activator, significantly increased from days 4 to 7 in the basilar artery after the initial SAH, and the continuous administration of 1,2-bis(nicotinamido)-propane (AVS), a novel free radical scavenger, not only lowered the concentration of lipid peroxides in the CSF but also successfully suppressed the basilar arterial narrowing and the increase of DAG in the basilar arterial wall in the same model. It was suggested that lipid peroxides generated in the subarachnoid clot affect the DAG content of the cerebral artery. Analysis of hydroxy-eicosatetraenoic acids (HETEs) with high performance liquid chromatography (HPLC) revealed the production of relatively large amount of 12-HETE in the subarachnoid clot. To examine the potential effect of exogenous 12-HETE on the DAG content of the cerebral artery, the basilar artery was incubated with 12-HETE in vitro. 12-HETE induced a concentration-dependent slow increase in DAG content in the arterial wall after 6 hours of incubation. Under conditions in which DAG formation was facilitated by the Ca++-ionophore, DAG accumulation in the basilar artery was enhanced in the presence of 12-HETE. It was suggested that 12-HETE generated in the subarachnoid clot, induced DAG accumulation in the arterial wall by inhibition of DAG metabolism, resulting in the induction of prolonged PKC-dependent smooth muscle contraction in the pathogenesis of cerebral vasospasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02187196
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  • 5
    Electronic Resource
    Electronic Resource
    Neural Activity of the Subthalamic Nucleus in Parkinson's Disease Patients (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 1287-1291 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Parkinson's disease; subthalamic nucleus; stereotactic surgery.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  The neural activity pattern of the subthalmic nucleus (STN) was investigated in five patients with Parkinson's disease who were scheduled for electrode implantation for chronic stimulation of the STN.  The initial target was placed 8 mm or 10 mm lateral to the midline, 3 mm to 4 mm posterior to the midcommissural point, and 5 mm to 6 mm below the intercommissural (AC-PC) line. The STN was identified by semi-microelectrode recordings with a trajectory moving laterally in 2-mm steps. The amplitudes of multi-unit activities were relatively low at depths from 8 mm to 5 mm above and from 1 mm to 4 mm below the target, while those 4 mm to 0 mm above the target were significantly higher than at the other sites (ANOVA, Fisher's test, p〈0.05), with the highest amplitude at 2 mm above the target (91.0±23.3μv, n=15). In the mediolateral direction, amplitudes were relatively higher in the lateral portion, and amplitudes at 14 mm lateral to the midline were significantly higher than at the other sites (ANOVA, Fisher's test, p〈0.05). The target for chronic electrical stimulation was determined to be at the midpoint of the hyperactive STN, i.e., 12 mm lateral to the midline in three patients and 13 mm lateral in two patients. Movement-related neural activity was observed at 5 sites, i.e., 3 sites responded to passive movement of the contralateral wrist and 2 sites to passive knee and/or ankle movement.  In conclusion, our data show that the lateral part of the STN is hyperactive in PD, and recordings of neural activities contributed greatly to identifying the STN and determining the target for chronic stimulation within it.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050251
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  • 6
    Electronic Resource
    Electronic Resource
    Characterization of Thermal Degradation of Stainless Steel with Ultrasonic Velocities and Backscattering Noise (1996)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 210-213 (May 1996), p. 283-288 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/01/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.210-213.283.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Acquired acrodermaties enteropathica during chemotherapy For acute lymphocytic leukaemia in a child with Down syndrome (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb03862.x
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  • 8
    Electronic Resource
    Electronic Resource
    Cytotoxicity of endogenous isoquinolines to human dopaminergic neuroblastoma SH-SY5Y cells (1997)
    Springer
    Journal of neural transmission 104 (1997), S. 59-66 
    Details
    ISSN: 1435-1463
    Keywords: Cytotoxicity ; isoquinolines ; N-methylsalsolinol ; 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion ; neuroblastoma SH-SY5Y cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Endogenous isoquinolines with and without catechol structure have been proposed to be neurotoxins specific for dopamine neurons. In this paper they were examined for the cytotoxicity of human dopaminergic neuroblastoma SH-SY5Y cells. The cytotoxicity was quantitatively determined using Alamar Blue assay, by which the reduction-oxidation potency in the living cells can be measured spectrometrically. 1,2-Dimethyl-6,7-dihydroxyisoquinolinium ion [1,2-DMDHIQ+], an oxidation product of a parkinsonism-inducing isoquinoline, 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahyroisoquinoline [N-methyl-(R)salsolinol, NM(R)Sal] was found to be the most potent toxin among isoquinolines examined. In general, catechol isoquinolines were more toxic than isoquinolines without catechol structure. With and without catechol structure, the oxidized isoquinolinium ion having methyl groups at C-1 and N-2 positions proved to be more cytotoxic than the simple isoquinolines. The involvement of 1,2-DMDHIQ+ to the neurotoxicity of NM(R)Sal was suggested and discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271294
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  • 9
    Electronic Resource
    Electronic Resource
    Effects of various tetrahydroisoquinoline derivatives on mitochondrial respiration and the electron transfer complexes (1998)
    Springer
    Journal of neural transmission 105 (1998), S. 677-688 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Parkinson's disease ; mitochondria ; complex I ; neurotoxins ; tetrahydroisoquinolines ; pathogenesis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. We report effect of various tetrahydroisoquinoline derivatives on mitochondrial respiration and the electron transfer complexes. Generally these compounds were potent inhibitors of NADH-linked mitochondrial state 3 respiration and complex I. Presence of a phenyl group at the C1 position or oxidation of N-methylated isoquinones into N-methylisoquinolinium ion augmented the potency to inhibit mitochondrial respiration and complex I. Many of these compounds have been identified in human brains. In view of the mitochondrial and oxidative stress hypothesis, our results suggest involvement of these neurotoxins as potential causes of mitochondrial failure in Parkinson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050087
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  • 10
    Electronic Resource
    Electronic Resource
    Progress in preclinical and clinical studies for the development of new anticancer drugs in Japan, with emphasis on taxanes (1996)
    Springer
    Cancer chemotherapy and pharmacology 38 (1996), S. S11 
    Details
    ISSN: 1432-0843
    Keywords: Key words Taxane ; Anticancer drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800051030
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