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Digitale Medien

Crystallization and structure solution of p53 (residues 326–356) by molecular replacement using an NMR model as template (1998)

Mittl, Peer R. E. ; Chène, Patrick ; Grütter, Markus G.

Copenhagen : International Union of Crystallography (IUCr)

Acta crystallographica 54 (1998), S. 86-89

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ISSN: 1399-0047

Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001

Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik

Notizen: The molecular replacement method is a powerful technique for crystal structure solution but the use of NMR structures as templates often causes problems. In this work the NMR structure of the p53 tetramerization domain has been used to solve the crystal structure by molecular replacement. Since the rotation- and translation-functions were not sufficiently clear, additional information about the symmetry of the crystal and the protein complex was used to identify correct solutions. The three-dimensional structure of residues 326–356 was subsequently refined to a final R factor of 19.1% at 1.5 Å resolution.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1107/S0907444997006550

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Digitale Medien

Comparative reject analysis in conventional film-screen and digital storage phosphor radiography (1999)

Peer, S. ; Peer, R. ; Walcher, M. ; [weitere]

Springer

European radiology 9 (1999), S. 1693-1696

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ISSN: 1432-1084

Schlagwort(e): Key words: Reject analysis ; Digital radiography ; Quality control

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract. The aim of this study was comparative analysis of rejected radiographs in conventional and digital radiology under the aspects number of rejected images and reasons for rejection. During 2 months waste films of conventional radiography were collected; in digital radiography each image-delete command at the postprocessing workstation was documented. Rejected images were analysed and assigned to four categories. The overall reject rate was 27.6 % in the conventional and 2.3 % in the digital department. Whereas in the conventional department the main reason for rejection was “exposure” and “others” (i. e. problems related to film handling), the main reason in the digital environment was “positioning”. The high exposure tolerance of digital systems markedly reduces the amount of faulty images. This is not only economically rewarding, but may also reduce unnecessary X-ray exposure of patients due to image retake.