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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Cellular and molecular life sciences 51 (1995), S. 245-248 
    ISSN: 1420-9071
    Schlagwort(e): Protein synthesis ; CA2+ activity ; ischemia ; hippocampus ; slice ; in vitro
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Increase in intracellular calcium concentration is a prominent feature of ischemia and has been considered a major factor in the initiation of ischemic pathology, which involves inhibition of protein synthesis. A reduction of calcium ion activity during and immediately after in vitro ischemia did not prevent inhibition of protein synthesis in hippocampae slices. When slices were overloaded with calcium by NMDA receptor activation or by the calcium ionophore A23187, no significant inhibition of protein synthesis was observed. We conclude that calcium overload plays only a limited role in ischemic inhibition of protein synthesis.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 0942-0940
    Schlagwort(e): Keywords: Gangliosides; microbore HPLC; astrocytoma; glioma.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary ¶ The composition and the content of gangliosides changes during physiological growth and differentiation as well as in neoplastic cell transformation. In order to determine if ganglioside profiles correlate with brain tumour malignancy, the ganglioside distribution was determined in 31 gliomas of astrocytic origin and in non-tumour tissue by a recently developed microbore high performance liquid chromatography (HPLC) method. Glioma malignancy was graded according to the grading system proposed by the World Health Organization (WHO) in 1993. In general, an increase of GD3 and a decrease of normal brain gangliosides correlated with a higher grade of malignancy. Pilocytic astrocytomas Grade I had a distinctive ganglioside profile, histologically as well as biochemically. Although they are low-grade gliomas, the pilocytic astrocytomas exhibited a GD3 content comparable to anaplastic gliomas and could only be biochemically distinguished from other tumour grades by relatively high type “b” ganglioside levels. Thus, ganglioside composition not only reflects anaplasia but can also be used to indicate biological characteristics of tumours of different histogenetic origin.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Surgical and radiologic anatomy 17 (1995), S. 325-327 
    ISSN: 1279-8517
    Schlagwort(e): Radiographs ; Colorcoding ; Monochromatic MoK α-radiation ; Intervertebral disc ; Chemonucleolysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé Les radiographies sont largement utilisées dans le domaine de la pathologie ostéo-articulaire. Des procédés spéciaux peuvent être utilisés pour améliorer la qualité de l'image. Nous rapportons une nouvelle technique radiographique qui utilise un rayonnement monochromatique de molybdène Kα associée à un codage couleur digital secondaire pour obtenir des images bien contrastées. Afin d'évaluer l'apport diagnostique de cette technique, des specimens de disques intervertébraux de cadavres ayant fait l'objet d'une chimio-nucléolyse par injection de chymopapaine ont été étudiés. Les radiographies des specimens réalisés avec un tube à rayons X avec anode en molybdène et un filtre de zirconium ont fait l'objet d'un traitement informatique et d'un codage couleur. Cette technique améliore la résolution et le contraste des images et ainsi l'analyse des modifications morphologiques.
    Notizen: Summary Radiographs are used in a wide variety of musculoskeletal examinations. Special procedures are required to improve image quality. We report a new radiologic technique that uses monochromatic molybdenumK α-radiation together with secondary digital color-coding to produce well contrasted images of supporting tissue. In order to investigate the diagnostic capability of this approach we studied specimens of the intervertebral disc, harvested from cadavers undergoing chemonucleolysis following an injection of chymopapain. Radiographs of the specimen taken using a Mo X-ray tube with a zirconium filter were scanned into a computerised image-processing system and color-coded. This method improves resolution and contrast in the images and allows the differentiation of morphologic changes.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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