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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 22 (1996), S. 964-967 
    ISSN: 1432-1238
    Keywords: Tissue oedema ; Total body water ; Pulsation ; Paediatric intensive care ; Open heart surgery ; Hospital beds ; Critical illness ; Bioelectrical impedance ; Specialty beds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To evaluate the effects of a pulsating air bed on the relief of tissue oedema and duration of intensive care unit (ICU) stay of children post-cardiac surgery. Design Random allocation. Setting Paediatric cardiac ICU. Patients and Participants Sixteen patients, aged 3–48 months, who underwent the surgical repair of atrioventricular sepatal defect. Intervention The treatment group received continuous postoperative management on a pulsating low airloss bed. The control group was managed on a standard non-pulsating bed. The end point of the study was that total body water (TBW) returned to preoperative levels. Measurements The TBW was measured by bioelectrical impedance and expressed as a percentage change of body weight as determined prior to treatment. Measurements were made before surgery, upon arrival on the ICU, and serially until TBW returned to preoperative levels. All patients were treated according to the standard ICU protocol, which includes strict fluid and diuretic regimens. Urine output, mean blood pressure and central venous pressure were measured. Results All patients developed a 2–20% increase in TBW above baseline after open heart surgery. Preoperative measurements and ICU admission values were identical. The maximum increase in TBW was reached 3–6 h after return to the ICU. These values were higher in the control group (p〈0.01). The TBW returned to normal in the treatment group at 24 h after surgery, and at 48–72 h after surgery in the control group (p〈0.001). There was a tendency for higher urine output and central venous pressure in the treated group. The duration of stay in the ICU was significantly less for the treated group (p〈0.05). Conclusions Continuous air pulsation by a specialty ICU bed reduced TBW, relieved tissue oedema, and improved hemodynamics in oedematous post-operative paediatric cardiac surgery patients. This reduced morbidity may have cost-effective implications relating to decreased ICU stay and resource consumption. Further studies to evaluate the use of this technology in critically ill children are warranted.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 22 (1996), S. 964-967 
    ISSN: 1432-1238
    Keywords: Key words Tissue oedema ; Total body water ; Pulsation ; Paediatric intensive care ; Open heart surgery ; Hospital beds ; Critical illness ; Bioelectrical impedance ; Specialty beds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To evaluate the effects of a pulsating air bed on the relief of tissue oedema and duration of intensive care unit (ICU) stay of children post-cardiac surgery. Design: Random allocation. Setting: Paediatric cardiac ICU. Patients and Participants: Sixteen patients, aged 3–48 months, who underwent the surgical repair of atrioventricular septal defect. Intervention: The treatment group received continuous postoperative management on a pulsating low air-loss bed. The control group was managed on a standard non-pulsating bed. The end point of the study was that total body water (TBW) returned to preoperative levels. Measurements: The TBW was measured by bioelectrical impedance and expressed as a percentage change of body weight as determined prior to treatment. Measurements were made before surgery, upon arrival on the ICU, and serially until TBW returned to preoperative levels. All patients were treated according to the standard ICU protocol, which includes strict fluid and diuretic regimens. Urine output, mean blood pressure and central venous pressure were measured. Results: All patients developed a 2–20% increase in TBW above baseline after open heart surgery. Preoperative measurements and ICU admission values were identical. The maximum increase in TBW was reached 3–6 h after return to the ICU. These values were higher in the control group (p〈0.01). The TBW returned to normal in the treatment group at 24 h after surgery, and at 48–72 h after surgery in the control group (p〈0.001). There was a tendency for higher urine output and central venous pressure in the treated group. The duration of stay in the ICU was significantly less for the treated group (p〈0.05). Conclusions: Continuous air pulsation by a specialty ICU bed reduced TBW, relieved tissue oedema, and improved hemodynamics in oedematous post-operative paediatric cardiac surgery patients. This reduced morbidity may have cost-effective implications relating to decreased ICU stay and resource consumption. Further studies to evaluate the use of this technology in critically ill children are warranted.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 73 (1998), S. 3399-3401 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have investigated the evolution of molecular beam epitaxy (MBE)-grown, CdSe self-assembled quantum dots on ZnSe surfaces using microphotoluminescence techniques. Bare CdSe dots at room temperature undergo Ostwald ripening over a time scale measured in days. At the elevated temperatures maintained for MBE growth and dot formation, ripening is expected to progress much faster. Capping the dots with a thin ZnSe layer "freezes" the ripening, allowing one to sample different stages of the dot evolution and subsequent characterization. We have grown eleven samples, each with a different time interval, or growth interruption, between dot formation and capping; the growth interruption times ranging from 0 to 300 s, during which the samples were kept at 300 °C. Using microphotoluminescence spectroscopy, we have resolved the sharp emission peaks due to individual dots in each sample and, by analyzing the ensemble characteristics, have identified a new regime in the evolution of CdSe dots. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 24 (1995), S. 117-140 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Peptide aldehyde inhibitors of the chymotrypsin-like activity of the proteasome (CLIP) such as N-acetyl-Leu-Leu-Nle-H (or ALLN) have been shown previously to inhibit the secretion of β-amyloid peptide (Aβ) from cells. To evaluate more fully the role of the proteasome in this process, we have tested the effects on Aβ formation of a much wider range of peptide-based inhibitors of CLIP than published previously. The inhibitors tested included several peptide boronates, some of which proved to be the most potent peptide-based inhibitors of β-amyloid production reported so far. We found that the ability of the peptide aldehyde and boronate inhibitors to suppress Aβ formation from cells correlated extremely well with their potency as CLIP inhibitors. Thus, we conclude that the proteasome may be involved either directly or indirectly in Aβ formation.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Oto-palato-digital syndrome type 1 is a rare condition with several features of concern to the anaesthetist. We report a patient who developed respiratory depression 5 h after general anaesthesia. This was subsequently found to be due to brainstem compression secondary to congenital deformities of the skull base and cervical vertebrae.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Decision sciences 27 (1996), S. 0 
    ISSN: 1540-5915
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Managing credit risk in financial institutions requires the ability to forecast aggregate losses on existing loans, predict the length of time that loans will be on the books before prepayment or default, analyze the expected performance of particular segments in the existing portfolio, and project payment patterns of new loans. Described in this paper are tools created for these functions in a large California financial institution. A forecasting model with Markovian structure and nonstationary transition probabilities is used to model the life of a mortgage. Logistic and regression models are used to estimate severity of losses. These models are integrated into a system that allows analysts and managers to depict the expected performance of individual loans and portfolio segments under different economic scenarios. With this information, analysts and managers can establish appropriate loss reserves, suggest pricing differentials to compensate for risk, and make strategic lending decisions.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 4 (1997), S. 880-894 
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Current amplification of heavy-ion beams is an integral feature of the induction linac approach to heavy-ion fusion (HIF). In this paper we report on amplification experiments conducted on a single beam of the Multiple Beam Experiment (MBE-4), a heavy-ion (Cs+) induction linac. Earlier MBE-4 experiments [H. Meuth et al., Nucl. Instrum. Methods Phys. Res. A 278, 153 (1989)] had demonstrated up-to-9× current amplification but had been accompanied by an up-to-2× increase of normalized transverse emittance. Experiments to pinpoint the causes of this emittance growth indicated various factors were responsible, including focusing aberrations and mismatch difficulties between the injector diode and the accelerator transport lattice, a localized quadrupole misalignment problem, and the interaction of transversely large beams with the nonlinear elements of the focusing lattice. Following ameliorative measures, new current amplification experiments, both with and without acceleration, showed that current amplifications of up to 3× and line charge density increases of up to (approximate)2× could be achieved without increasing the beam's normalized transverse emittance. Finally, both the transverse beam dynamics, and beam current and energy measurements were accurately modeled by numerical particle-in-cell simulations and longitudinal dynamics codes, respectively. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 7 (1995), S. 1455-1466 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In this paper we report measurements of differential diffusion in nonreacting jet flows. Pulsed laser Raman scattering spectroscopy is used to measure species concentrations in nonreacting jets of H2/CO2 into air over a range of Reynolds numbers from 1000 to 64 000. Measurements are also made in strained laminar opposed flows of H2/CO2 against air, where differential diffusion effects on relative species concentrations are observed to be independent of strain rate. In laminar opposed flows and in a laminar jet (Re=1000), measurements of average species concentrations show significant differential diffusion effects. In jet flows of higher Reynolds numbers, only instantaneous species concentrations are affected by differential diffusion; measured species concentrations are the same, on average, as the species concentrations that would have been observed if all species diffusivities were equal. Instantaneous differential diffusion effects in turbulent jets are quantified by the variance of a differential diffusion variable z, where z is the difference between the normalized mole fractions of H2 and CO2 (and normalization refers to dividing each species mole fraction by the mole fraction of that species in pure jet fluid). Measurements show that zRMS diminishes with increasing Reynolds number. Histograms of z show negative skewness in the low Reynolds number jet. At higher Reynolds numbers the histograms become more symmetric, although asymmetries do remain at higher Reynolds numbers in the data obtained near the jet edge, where there is an interface between jet fluid and coflowing air. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 9 (1997), S. 667-678 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: An experimental investigation of the non-reactive mixing processes associated with a lobed fuel injector in a coflowing air stream is presented. The lobed fuel injector is a device which generates streamwise vorticity, producing high strain rates which can enhance the mixing of reactants while delaying ignition in a controlled manner. The lobed injectors examined in the present study consist of two corrugated plates between which a fuel surrogate, CO2, is injected into coflowing air. Acetone is seeded in the CO2 supply as a fuel marker. Comparison of two alternative lobed injector geometries is made with a straight fuel injector to determine net differences in mixing and strain fields due to streamwise vorticity generation. Planar laser-induced fluorescence (PLIF) of the seeded acetone yields two-dimensional images of the scalar concentration field at various downstream locations, from which local mixing and scalar dissipation rates are computed. It is found that the lobed injector geometry can enhance molecular mixing and create a highly strained flowfield, and that the strain rates generated by scalar energy dissipation can potentially delay ignition in a reacting flowfield. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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