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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Mineralium deposita 33 (1997), S. 98-110 
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Resumen (translated by E. Pascual) Las formaciones ígneas asociadas con los depósitos de sulfuros masivos de la Faja Pirítica Ibérica (IPB) se componen esencialmente de doleritas y lavas básicas y de rocas volcánicas dacíticas a riolíticas; las lavas intermedias son poco abundantes. Las rocas básicas muestran caracteres geoquímicos variables: lavas y doleritas comparables a basaltos alcalinos intraplaca recientes parecen hasta ahora restringidos a las partes W y S de la IPB, mientras que rocas básicas de caracteres comparables a las de toleítas continentales o basaltos relacionados con arcos aparecen en toda la zona. Las rocas ácidas se clasifican como calcoalcalinas del tipo “low-Al2O3, high-Yb”. Para un contenido dado en SiO2, Al2O3 y TiO2, muestran contenidos variables en Zr, Nb y REE. El contenido en tierras raras pesadas decrece de dacitas a riolitas ([Gd/Yb]N ∼ 1), al tiempo que la anomalía de Eu se hace más pronunciada. La modelización de elementos trazas sugiere que las rocas evolucionaron a partir de un magma parental dacítico mediante cristalización fraccionada de hornblenda y plagioclasa. La fusión parcial de un protolito anfibolítico, que parece el modelo más plausible para el origen del magma dacítico, requiere un elevado gradiente T/P en la corteza. La existencia de basaltos alcalinos y de toleítas continentales es congruente con la formación de la IPB en un entorno tectónico distensivo. El emplazamiento en una cuenca “fore-arc”, en un segmento cortical de reciente acreción, se contempla como una hipótesis posible para explicar los caracteres geológicos y petrológicos. Un alto gradiente térmico, junto con la erupción en una cuenca submarina extensional, pueden haber sido los dos ingredientes clave en el desarrollo de los depósitos de sulfuros masivos en la IPB.
    Notes: Abstract Igneous formations associated with massive sulphide deposits in the Iberian Pyrite Belt (IPB) are essentially composed of basic lavas and dolerites, and dacitic to rhyolitic volcanites; intermediate lavas are subordinate. The basic rocks show variable geochemical characteristics: lavas and dolerites comparable to recent within-plate alkaline basalts seem restricted to the western and southern parts of the IPB, whereas basic rocks comparable to continental tholeiites or arc-related basalts occur across the whole belt. The felsic rocks are classified as calc-alkaline and belong to the “low-Al2O3 and high-Yb type”. At given SiO2, Al2O3 and TiO2 contents, they show variable Zr, Nb, and HREE contents. Heavy-rare-earth element fractionation decreases from the dacites to the rhyolites ([Gd/Yb]N ∼ 1), whereas the negative Eu-anomaly becomes more pronounced. The characteristics of the rhyolites are typical of sulphide-fertile volcanic packages. Trace-element modelling suggests that the felsic rocks evolved from a dacitic parent magma through fractional crystallization of hornblende and plagioclase. Partial melting of an amphibolite protolith, which appears as the most probable model for the origin of this dacitic magma, requires a high T/P gradient in the crust. The occurrence of alkaline basalts and continental tholeiites is consistent with formation of the IPB in a tensional tectonic setting. However, the associated island-arc tholeiites suggest a location in a domain of plate convergence. Emplacement in a fore-arc basin over a recently accreted crustal segment is envisaged as a possible hypothesis to account for the geological and petrological constraints. A high geothermal gradient and eruption in a submarine tensional basin could have been two key ingredients for the development of massive sulphide deposits within the IPB.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1041
    Keywords: Key words  Cancer patients ; Cytokines ; Mistletoe extract ; Viscum album ; Peripheral blood mononuclear cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: Mistletoe extracts are used in adjuvant cancer treatment, but little is known concerning their mode of action. There is, however, evidence that antigens in these extracts may stimulate cells of the immune system, thereby modifying the altered immunological reactivity in tumour patients. Methods: In order to find out whether the postulated immunomodulatory properties of mistletoe extracts are mediated by cytokines, a spectrum of different cytokines was analysed in the supernatants of peripheral blood mononuclear cells (PBMC) from healthy (n = 23) and allergic (n = 16) individuals after stimulation with the fermented mistletoe lectin-1 (ML-1) free mistletoe extract Iscador Pini (IP) in vitro, and their cytokine patterns were compared to those from tumour patients with either breast cancer (n = 20) or colorectal tumours (n = 22). Results: PBMC from healthy and allergic individuals produced high levels of TNF-α and IL-6 and to a lesser extent Th1- and Th2-related cytokines. This finding was in contrast to data obtained in tumour patients. Thus, the concentration of TNF-α was significantly lower in the cell cultures from breast cancer patients than in controls, and patients with colorectal tumours released IFN-γ/IL-2 (5%) in the supernatants significantly less frequently than PBMC from healthy controls (26%). Similar results were obtained when the Th1- and monocyte/macrophage-related cytokines were analysed in the unstimulated cell cultures. Conclusions: These in vitro studies provide evidence that there is a reduced immunological reactivity to the fermented ML-1 free mistletoe extract in tumour patients and may give some clues as to how mistletoe-derived antigens could act on immune cells involved in the tumour defence.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 318-320 (Oct. 1999), p. 151-160 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 318-320 (Oct. 1999), p. 261-270 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 318-320 (Oct. 1999), p. 161-166 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 318-320 (Oct. 1999), p. 167-174 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1438-2199
    Keywords: Amino acids ; ADPKD ; Renal failure ; Renal amino acid-/sodium handling ; Hypertension ; Nitric oxide ; Cyclic GMP ; Na+/K+-ATPase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Although ADPKD is one of the first kidney diseases to be understood from the gene to the pathogenesis of clinical abnormalities, there were no data concerning the renal handling of amino acids and possible disorders of amino acid (AA) pattern in these patients. Therefore, in 9 patients suffering from ADPKD and in 8 healthy normal persons (NP) renal amino acid excretion was measured before and after extracellular volume expansion (ECVE) (21 of physiological electrolyte solution). Renal function was stable in both groups (serum creatinine: ADPKD: 85.1 ± 18.4 vs. NP 84.4 ± 13.5 μmol/l; GFR: 93.8 ± 16.4 vs. 104.4 ± 9.4 ml/min/1.73 m2). Mean blood pressure was higher in ADPKD patients than in NP (99.4 ± 2.6 vs. 85.5 ± 2.4 mmHg), but did not change after ECVE. After ECVE in both groups, urine volume increased distinctly, whereas GFR was only slightly enhanced. The plasma concentrations of leucine, glycine, valine, threonine, glutamine, and alanine were significantly higher in controls than in ADPKD patients. The amino acid reabsorption capacity was reduced in ADPKD patients in 12 of 21 amino acids before ECVE. After ECVE, the fractional excretion of amino acids (FEAA) increased only in NP. In parallel with changes in amino acid handling, the FENa (%) after ECVE increased both in ADPKD patients and in NP (before ECVE - ADPKD: 1.22 ± 0.23 vs. NP: 1.53 ± 0.23; after ECVE: 3.17 ± 0.25 (ADPKD) vs. 2.74 ± 0.22/NP; (ADPKD p ≤ 0.01, NP p ≤ 0.02) whereas FELi (%) increased significantly only in ADPKD (p ≤ 0.045) range (before ECVE - ADPKD: 25.8 ± 8.9 vs. NP: 20.5 ± 4.0; after ECVE: 41.4 ±15.4 vs. 25.2 ± 3.9). Furthermore, concentrations of cGMP (pmol/ml) in plasma increased after ECVE (before ECVE - ADPKD: 5.31 ± 0.56 vs. NP: 6.65 ±0.79; after ECVE: 11.31 ± 1.66 vs. 11.30 ± 1.91; p ≤ 0.05). Na+-dependent and, perhaps, NO-mediated processes in the reabsorption of AA in the proximal tubule seem to be different in ADPKD and may be related to different distributions of receptors and ATP-dependent transport systems with pathogenetic impact on abnormal transtubular fluid transport in ADPKD.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0827
    Keywords: Key words: Rheumatoid arthritis — Osteopenia — Disease activity — Vitamin D metabolites.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. In several studies on patients with rheumatoid arthritis, an association of bone loss with a persistently high disease activity has been found. The aim of our study was to investigate the relation between disease activity and serum levels of vitamin D metabolites, parathyroid hormone (PTH), and parameters of bone turnover in patients with rheumatoid arthritis. A total of 96 patients (83 women and 13 men) were divided into three groups according to disease activity measured by serum levels of C-reactive protein (CRP). In the whole group, serum levels of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) (P 〈 0.001) and PTH (P 〈 0.05) were negatively correlated to disease activity. The urinary excretion of collagen crosslinks—pyridinoline (Pyd) (P 〈 0.001) and deoxypyridinoline (Dpd) (P 〈 0.05)—showed a positive correlation with disease activity. The inverse correlation between serum 1,25(OH)2D3 and disease activity was separately evident in patients with (P 〈 0.001) and without (P 〈 0.01) glucocorticoid treatment, in pre- (P 〈 0.01) and postmenopausal (P 〈 0.001) women, and in men (P 〈 0.01). 1,25(OH)2D3 and PTH serum levels were positively correlated to serum bone alkaline phosphatase (ALP) (P 〈 0.01). The results indicate that high disease activity in patients with rheumatoid arthritis is associated with an alteration in vitamin D metabolism and increased bone resorption. The decrease of 1,25(OH)2D3 levels in these patients may contribute to a negative calcium balance and inhibition of bone formation. Furthermore, low levels of 1,25(OH)2D3 as an endogenous immunomodulator suppressing activated T cells and the proliferation of cells may accelerate the arthritic process in rheumatoid arthritis.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1041
    Keywords: Key words Hypertensive crisis ; Nifedipine ; Felodipine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: A clinical definition of a hypertensive emergency is excessively high blood pressure in the presence of symptoms indicating end organ damage. Equally high blood pressure without symptoms is called a hypertensive crisis. Patients with hypertensive crisis or emergency need prompt, effective, and specific therapy and a controlled reduction of blood pressure. Methods: We performed a randomized, double-blind multi-centre study, to compare the safety, efficacy and tolerability of an intravenous (IV) infusion of two dihydropyridine calcium channel blockers (either nifedipine or felodipine) in 122 patients, of whom 63 were diagnosed as hypertensive emergencies and 59 as hypertensive crisis, who had not reacted adequately (diastolic blood pressure 〈115 mmHg) to 5 mg of nifedipine PO. Results: Both drugs lowered blood pressure adequately in more than 90% of the patients and were well tolerated. Only one patient had to be withdrawn, because of an excessive decrease in blood pressure. Conclusion: Patients with excessively high blood pressure who do not react to oral nifedipine can be treated equally effectively with felodipine and nifedipine IV. Felodipine is easier to handle because of its lack of light sensitivity.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1437-160X
    Keywords: Systemic lupus erythematosus ; Azathioprine therapy ; dsDNA antibodies ; Incidence of flares
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Many patients with systemic lupus erythematosus (SLE) receive long-term treatment with azathioprine and prednisolone to control disease activity. In a retrospective study we evaluated the efficacy of combined treatment with azathioprine (2 mg/kg body weight/d) and low-dose prednisolone (7–12 mg/d) and the predictors of disease flares during this therapy regimen in 61 patients with SLE. We found three predictors of flares: renal disease, persistence of dsDNA antibodies for at least 1 year after the beginning of treatment and reduction in azathioprine dosage to below 2 mg/kg/d. The occurrence of flares was significantly associated with a higher rate of disease-related death. Furthermore, the persistence of dsDNA antibodies for at least 2 years was associated with progression of renal disease. We concluded that suppression of production of dsDNA antibodies with high avidity is a suitable parameter to determine efficacy of treatment and long-term outcome during combined therapy with azathioprine and low-dose prednisolone in SLE.
    Type of Medium: Electronic Resource
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