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  • 1
    Electronic Resource
    Electronic Resource
    Total Synthesis of the Angucycline Antibiotics Urdamycinone B and 104-2 via a Common Synthetic Intermediate (1995)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 117 (1995), S. 8472-8473 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00137a026
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  • 2
    Electronic Resource
    Electronic Resource
    Incorporation of 15-hydroxyeicosatrienoic acid in specific phospholipids of cultured human keratinocytes and psoriatic plaques (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 4 (1995), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract 15-hydroxyeicosatrienoic acid, 15-HETrE, the 15-lipoxygenase product of dihomogammalinolenic acid (DGLA), can inhibit the biosynthesis of the proinflammatory eicosanoids leukotriene B4 (LTB4) and 12-hydroxyeicosatctraenoic acid (12-HETE). The purpose of the present study was to investigate the incorporation of [I4C] 15-HETrE in specific membrane phospholipids of cultured human keratinocytes in vitro. [I4C] 15-HETrE was rapidly incorporated into keratinocytes. When a plateau was reached after 3 hours, 15% of the added radioactivity was incorporated into lipids; 96.5% into phospholipids (PL) and 3.5%. into neutral lipids (NL). Within the phospholipid classes, [I4C]15-HETrE showed selectivity for incorporation into phosphatidylinositol (PI). The mean proportion of [I4C] 15-HETrE in the PI, phosphatidylcholin (PC) and phosphatidyle-thanolamin (PE) was 83.2%, 8.5% and 8.3%, respectively. We then investigated the incorporation of 15-HETrE in epidermal phospholipids of psoriatic skin intralesionally injected with 15-HETrE. Four patients took part in the study. In each patient four identical plaques were injected with 0.65 ml of 2.0 µM, 6.2 µM, 18.6 µM of 15-HETrE (0.4 µg, 1, 2 µg and 3.6 µg respectively) or 0.65 ml of 0.88% NaCl twice a week. After 3 wk keratome biopsies were obtained from the treated plaques. Phospholipids extracted from the skin biopsies were separated into major classes by two-dimensional thin layer chromatography. 15-HETrE was then released from specific phospholipids after treatment with phospholipase A2 and identified by reverse phase and straight phase high preformance liquid chromatography. There was a dose-dependent incorporation of 15-HETrE into the specific phospholipids PI and PC. When expressed as ng 15-HETrE/ug phospholipid phosphate, 15-HETrE accumulated preferent-ically in PI. After injection of the highest 15-HETrE concentration, the mean amount of 15-HETrE estcrified in PI and PC was 81.9 ng/µg PI phosphate and 19.4 ng/µg PC phosphate, respectively. This incorporation of 15-HETrE incorporated into epidermal PLs was not accompanied by a clinical change of the treated psoriatic plaques. It remains to be determined whether higher 15-HETrE incorporated might induce clinical improvement of psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1995.tb00225.x
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  • 3
    Electronic Resource
    Electronic Resource
    Antitumor Activity of 5-Aryl-2,3-dihydroimidazo[2,1-a]isoquinolines (1995)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 38 (1995), S. 234-240 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00002a004
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  • 4
    Electronic Resource
    Electronic Resource
    Regulation of Synaptotagmin I Phosphorylation by Multiple Protein Kinases (1999)
    Oxford UK : Blackwell Science Ltd
    Journal of neurochemistry 73 (1999), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract : Synaptotagmin I has been suggested to function as a low-affinity calcium sensor for calcium-triggered exocytosis from neurons and neuroendocrine cells. We have studied the phosphorylation of synaptotagmin I by a variety of protein kinases in vitro and in intact preparations. Syntagl, the purified, recombinant, cytoplasmic domain of rat synaptotagmin I, was an effective substrate in vitro for Ca2+/calmodulin-dependent protein kinase II (CaMKII), protein kinase C (PKC), and casein kinase II (caskII). Sequencing of tryptic phosphopeptides from syntagl revealed that CaMKII and PKC phosphorylated the same residue, corresponding to Thr112, whereas CaskII phosphorylated two residues, corresponding to Thr125 and Thr128. Endogenous synaptotagmin I was phosphorylated on purified synaptic vesicles by all three kinases. In contrast, no phosphorylation was observed on clathrin-coated vesicles, suggesting that phosphorylation of synaptotagmin I in vivo occurs only at specific stage(s) of the synaptic vesicle life cycle. In rat brain synaptosomes and PC12 cells, K+-evoked depolarization or treatment with phorbol ester caused an increase in the phosphorylation state of synaptotagmin I at Thr112. The results suggest the possibility that the phosphorylation of synaptotagmin I by CaMKII and PKC contributes to the mechanism(s) by which these two kinases regulate neurotransmitter release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1999.0730921.x
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  • 5
    Electronic Resource
    Electronic Resource
    Sustained Neurotransmitter Release: New Molecular Clues (1997)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 9 (1997), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Chemical synapses convey impulses at high frequency by exocytosis of synaptic vesicles. To avoid failure of synaptic transmission, rapid replenishment of synaptic vesicles must occur. Recent molecular perturbation studies have confirmed that the recycling of synaptic vesicles involves clathrin-mediated endocytosis. The rate of exocytosis would thus be limited by the capacity of the synaptic clathrin machinery unless vesicles could be drawn from existing pools. The mobilization of vesicles from the pool clustered at the release sites appears to provide a mechanism by which the rate of exocytosis can intermittently exceed the rate of recycling. Perturbation of synapsins causes disruption of vesicle clusters and impairment of synaptic transmission at high but not at low frequencies. Both clathrin-mediated recycling and mobilization of vesicles from the reserve pool are thus important in the replenishment of synaptic vesicles. The efficacy of each mechanism appears to differ between synapses which operate with different patterns of activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.1997.tb01679.x
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  • 6
    Electronic Resource
    Electronic Resource
    Special Research Focus on Supply Chain Linkages: Challenges for Design and Management in the 21st Century (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Decision sciences 29 (1998), S. 0 
    Details
    ISSN: 1540-5915
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Supply chain management is a central and important area for academic research due to its impact on firms competing in today's global economy. Managing the flow of materials from supply sources to the ultimate customer represents a major challenge for today's managers. To assist managers, the concept of supply chain management has been adopted by many business leaders as an important way to assist in designing, planning, and controlling the network of facilities and tasks that comprise the many stages of the supply chain. In turn, the flow of academic research in the area has increased to provide a better set of guidelines for effective implementation and execution.This article sets the stage for recently completed research concentrating on supply chain management issues. First, a definition of supply chain management is provided and compared to recent usage in this area and logistics management. Also, a framework is provided that structures this dynamic and complex management task. Second, a review of past research is presented to illustrate the many paths supply chain management has traveled, and important contributions to supply management understanding and decision making. Third, recently completed research articles are introduced that have been selected to be part of this special issue of Decision Sciences. And fourth, future research directions for supply chain management that need to be pursued by interested investigators are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-5915.1998.tb01353.x
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  • 7
    Electronic Resource
    Electronic Resource
    On the turbulent transport of a passive scalar by anisotropic turbulence (1996)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 8 (1996), S. 1312-1320 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The effect of anisotropic turbulence on the vertical transport of a tracer in a fluid layer is investigated numerically. It is found that for a fixed vertical turbulence spectrum an increase in the intensity of horizontal turbulence reduces the efficiency of the vertical transport. The reduction factor is inversely proportional to the anisotropy (defined as the ratio of horizontal to vertical rms velocities) for large Peclet numbers. This effect had been overlooked in studies of turbulent particle transport in stratified media, where the reduction in vertical transport coefficients was entirely attributed to vertical mode suppression by stratification. Our study is based on Gaussian velocity fields. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.868912
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  • 8
    Electronic Resource
    Electronic Resource
    A high spatial resolution distributed optical fiber sensor for high-temperature measurements (1997)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 68 (1997), S. 3772-3776 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: One of the advantages of the use of optical fibers for sensing is their ability to perform distributed measurements. Several distributed sensors that measure temperature along optical fibers are already commercially available. All of them are based on Raman thermometry. However, the spatial resolution that they achieve is limited to 1 m, making them unsuitable for applications where higher spatial resolution is needed. Also, their temperature range is very dependent on the behavior of fibers at high temperature, a subject which still needs investigation. In this article, we present a distributed optical fiber sensor that addresses these two issues. On one hand, the combination of Raman thermometry with the time-correlated single-photon counting technique permits the achievement of high spatial resolutions (0.1 m). On the other hand, the use of specially coated fibers allows measurement of high temperatures. We have investigated the system temperature sensitivity and have evaluated the measurement errors introduced by the high-temperature behavior of carbon- and gold-coated fibers. We demonstrate that the system is very appropriate for high-temperature distributed measurements with high spatial resolution. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1148025
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  • 9
    Electronic Resource
    Electronic Resource
    Nanoindentation investigation of the Young's modulus of porous silicon (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 80 (1996), S. 3772-3776 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Young's modulus of porous silicon samples, with porosity ranging from 36% to 90%, is measured by the nanoindentation technique. The analysis of the nanoindentation data, including the specific problem linked with porous materials, is presented. The Young's modulus values Ep thus obtained appear to be drastically dependent on the porosity and on the doping level (p or p+ type). The dependence of Ep versus the relative density (for a series of p+ type samples) is quadratic, in good agreement with the model of Gibson and Ashby developed for cellular materials. This also shows that highly porous silicon layers exhibit very low Young's modulus (for a porosity of 90% it is about two orders of magnitude smaller than that of the nonporous material). © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.363305
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  • 10
    Electronic Resource
    Electronic Resource
    Dispersant-Binder Interactions in Aqueous Silicon Nitride Suspensions (1999)
    Westerville, Ohio : American Ceramics Society
    Journal of the American Ceramic Society 82 (1999), S. 0 
    Details
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The interaction of dispersant and binder on the surface of particles was studied to identify the effect of these additives on aqueous ceramic powder processing. Poly(methacrylic acid) (PMAA) and poly(vinyl alcohol) (PVA) were used as the dispersant and binder, respectively. The adsorption isotherms of the organic additives on silicon nitride were determined. The adsorption of PMAA was differentiated from PVA in the mixed additive system via ultraviolet spectroscopy. The electrokinetic behavior of silicon nitride was measured by using an electrokinetic sonic amplitude analyzer. As the PMAA concentration increased, the isoelectric point (pHiep) of silicon nitride shifted from pH 6.7 ± 0.1 to acidic pH values. The magnitude of the shift depended on the surface coverage of PMAA. PVA did not affect the pHiep of suspensions but did cause a moderate decrease in the near-surface potential. Finally, the rheological behavior of silicon nitride suspensions was measured to assess the stability of particles against flocculation in aqueous media; this behavior was subsequently correlated with the electrokinetic and adsorption isotherm data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1151-2916.1999.tb01843.x
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