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  • 1
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1420-908X
    Keywords: Key words: Nitric oxide — Tendon healing — Free radical — Wound healing — Nitric oxide synthase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Nitric oxide (NO.) is a small, diffusible free radical that is generated from L-arginine by a family of enzymes, collectively termed the nitric oxide synthases. We investigated the role of NO. in tendon healing. NO. synthase activity and immunoreactivity was absent in un-injured rat Achilles tendon. After surgical division there was a five-fold increase in NO. synthase activity and immunoreactivity within the healing tendon at day 7, with a return to near baseline levels at day 14. Inhibition of NO. synthase activity with oral administration of N〈omega〉-nitro-L-arginine methyl ester (L-NAME) resulted in a significant reduction in cross-sectional area (30% at day 7, p 〈 0.01, 50% at day 15, p 〈 0.001) and failure load (24% at day 7, p 〈0.01) of the healing Achilles tendon constructs. Rats fed the same regimen of the enantiomer of L-NAME, (D-NAME) had normal tendon healing. These results indicate that nitric oxide synthase is induced during tendon healing and inhibition of nitric oxide synthase inhibits this tendon healing.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Abdominal imaging 23 (1998), S. 40-44 
    ISSN: 1432-0509
    Keywords: Key words: Diaphragm disease—Drug-induced enteropathy—Small-bowel inflammation—Small-bowel strictures.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Purpose: To identify the clinical and radiologic findings in patients with diaphragm-like strictures in the small bowel. Patients and methods: We reviewed the histories, radiologic findings, and pathologic findings in two men and two women, all in their sixties, with a history of long-term nonsteroidal antiinflammatory drug (NSAID) or aspirin (ASA) usage and one or more radiologically demonstrated diaphragm-like strictures in the small bowel. Results: Two patients had long histories of NSAID usage, and two of ASA usage. One NSAID user had a long segment of jejunal involvement, and the other three had short segments of duodenal involvement. The ASA users presented with symptoms of esophageal disease, the small bowel lesions were unexpected, and ASA usage was not initially elicited. In one NSAID user and one ASA user, broader strictures with humps rather than diaphragms were also seen producing a lifesaver-like or bagel-like configuration. Conclusions: Multiple diaphragm-like strictures can occur in NSAID injury and are pathognomonic except in the rare patient with ulcerative enteritis complicating celiac disease. Single or few diaphragm-like strictures can occur in NSAID injury and peptic ulceration. ASA should be considered an NSAID with regard to small-bowel toxicity. A careful medication history is required when an unexplained small bowel abnormality is seen radiologically, and a dedicated small bowel examination is required when NSAID injury is suspected.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Bingley : Emerald
    Leadership & organization development journal 16 (1995), S. 35-39 
    ISSN: 0143-7739
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: Most serious organizational change efforts of the last two decadeshave focused on change within groups or the socio-technical system. Harddata on change efforts are both limited and present a mixed picture ofthe effectiveness of these efforts, particularly over an extended periodof time. Presents ideas, notions and concepts about the role of theindividual within organizations which may help to explain some of thefailures and increase the probability of successful change. Likeindividuals, organizations consist of body (participants' common goals,beliefs of background), and spirit (individuals' ideas, assumption andthought processes). The artificial system of an organization (spirit) isman-made and owes its continued existence to the ideas, assumptions andthought processes in the minds of the individual within theorganization. Consistent with this notion, develops the concept that forreal long-term organizational change to occur, the systems existingwithin the minds of individuals must be altered. Further, proposes thatlanguage, values, norms and ethics are the factors which hold anorganization together and, since these factors are developed withinindividuals, they must be accounted for in change efforts. Also focuseson leaders and managers and their roles in organizational change.Specific characteristics of leaders which enable them to promote andfoster change are identified and discussed. It is noted that for leadersto be successful they must (1) free themselves from themselves, (2) freethemselves from the artificial systems of organizations, and (3) takespecific responsibility for their actions.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    Disaster prevention and management 6 (1997), S. 311-317 
    ISSN: 0965-3562
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Technology
    Notes: A reprint of a classic article chronicles the simulated incident of a plane crashing into the John Hancock Tower in Boston, Massachusetts. Recounts how the plan was developed and practised by the scenario team. Inclusion by the practice team of the local fire department and paramedics paralleled reality. The exercise demonstrated that the Tower, even with an emergency plan, needed stronger preparation. This was effective because on 11 August 1992, an actual emergency occurred in the facility and the building was prepared as a result of the simulation.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 799 (1996), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Biotechnology progress 11 (1995), S. 45-49 
    ISSN: 1520-6033
    Source: ACS Legacy Archives
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Microbiology 50 (1996), S. 183-212 
    ISSN: 0066-4227
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract Microorganisms are efficient degraders of starch, chitin, and the polysaccharides in plant cell walls. Attempts to purify hydrolases led to the realization that a microorganism may produce a multiplicity of enzymes, referred to as a system, for the efficient utilization of a polysaccharide. In order to fully characterize a particular enzyme, it must be obtained free of the other components of a system. Quite often, this proves to be very difficult because of the complexity of a system. This realization led to the cloning of the genes encoding them as an approach to eliminating other components. More than 400 such genes have been cloned and sequenced, and the enzymes they encode have been grouped into more than 50 families of related amino acid sequences. The enzyme systems revealed in this manner are complex on two quite different levels. First, many of the individual enzymes are complex, as they are modular proteins comprising one or more catalytic domains linked to ancillary domains that often include one or more substrate-binding domains. Second, the systems are complex, comprising from a few to 20 or more enzymes, all of which hydrolyze a particular substrate. Systems for the hydrolysis of plant cell walls usually contain more components than systems for the hydrolysis of starch and chitin because the cell walls contain several polysaccharides. In general, the systems produced by different microorganisms for the hydrolysis of a particular polysaccharide comprise similar enzymes from the same families.
    Type of Medium: Electronic Resource
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