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  • 1
    Electronic Resource
    Electronic Resource
    Lipidosis of the dorsal root ganglia in rats treated with an almitrine metabolite (1995)
    Springer
    Archives of toxicology 69 (1995), S. 391-396 
    Details
    ISSN: 1432-0738
    Keywords: Key words Almitrine bismesylate ; Detriazinyl ; metabolite of almitrine ; Cationic amphiphilic drugs ; Drug-induced lipidosis ; Neuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Toxic effects of a detriazinyl metabolite of almitrine (DTMA) were evaluated in rats and on cultured rat macrophages. In rats daily treated with DTMA for 16 weeks, spastic gaits with heel-lifting appeared, and lamellated and/or crystalloid bodies formed in sensory neurons, satellite cells, Schwann cells, and vascular endothelial cells of the dorsal root ganglia. The lysosomal lamellated bodies, which were not induced by almitrine, were produced also in cultured rat macrophages exposed to over 1×10–5 M DTMA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050189
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Blood flow rate in jejunal ischemia-reperfusion injury (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 762-764 
    Details
    ISSN: 1420-9071
    Keywords: Blood flow rate ; laser Doppler flowmeter ; jejunal ischemia-reperfusion injury ; anesthetized rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We examined changes in the blood flow rate in the course of jejunal ischemic injury using a laser Doppler flowmeter. For this purpose, we designed a sensor holding system, which involved the fixation of the sensor to the jejunum and allowed their movements to be synthronized. When the jejunum was reperfused after 10 min of ischemia, the blood flow rate markedly increased and then gradually decreased to the initial level. A 30-min period of ischemia produced the slowest recovery of the blood flow rate. This system could be useful for monitoring the blood flow rate in different anatomical regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01922426
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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