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  • Artikel: DFG Deutsche Nationallizenzen  (19)
  • 1990-1994  (19)
  • 1
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 724 (1994), S. 0 
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 125 (1991), S. 0 
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary Hairless mice were exposed to UVB irradiation from a Philips T1 12 light source. Mice that were exposed to UV-light and not protected with 5%p-aminobenzoic acid (PABA) showed a significantly higher number of peripheral blood granulocytes (P〈0·001) and a significantly higher mean weight of both the spleen and the liver (P〈0·001) than the non-irradiated controls. light microscopy of the histology of the enlarged liver and spleen showed a proliferation of granulocytes and the reticuloendothelial cells. Treatment with topical PABA during the whole period of UV-exposure prevented the peripheral blood granulocytosis. These protected mice also had a significantly (P 〈0·001) lower mean weight for the liver and spleen than UV-exposed and non-protected mice.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 28 (1993), S. 0 
    ISSN: 1600-0765
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Colonization or emergence of microbial pathogens may result in tissue destruction by activation of one or more of five distinct host degradative pathways (matrix metalloproteinase pathway, plasminogen-dependent pathway, phagocytic pathway, PMN-serine proteinase pathway and osteoclastic bone resorption) or by direct cleavage of extracellular matrix constituents by microbial proteinases. Activation of endogenous destructive pathways may be mediated by immune responses resulting in expression of degradative cellular phenotypes among both immigrant and resident cell populations. In addition, expression of degradative phenotypes may be triggered by direct influences on host cells of microbial products (LPS, enzymes, toxins). A body of evidence suggests that each of these mechanisms involves local production of proinflammatory cytokines and growth factors. The matrix metalloproteinase pathway is centrally involved in dissolution of all unmineralized connective tissues and perhaps in resorption of bone as well. The matrix metalloproteinase family consists of nine or more genetically distinct Zn++ endopeptidases which collectively cleave all of the constituents of the extracellular matrix. Recent studies have uncovered many essential elements of a complex, but still incomplete, regulatory network that governs tissue destruction. Proinflammatory cytokines and growth factors induce signalling pathways several of which are dependent on protein kinase C and result in transient expression of the transcription factors c-jun and c-fos. Initiation of transcription of most matrix metalloproteinase genes requires binding of the transcription factor AP-1 (c-jun/c-fos) to a specific promoter sequence but attainment of maximal transcription rates is dependent on interaction with other promoter elements as well. Several matrix metalloproteinases have been detected in crevicular fluids and tissues of inflamed human gingiva as have the proinflammatory cytokines (IL-1 and TNF-α) which regulate their transcription. Although the mere presence of enzymes and cytokines does not necessarily impart function per se, these observations suggest that some level of spatial or temporal linkage exists between metalloproteinase/cytokine expression and gingival inflammation.
    Materialart: Digitale Medien
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  • 4
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé Le risque de mortalité à 30 jours a été évalué chez 13854 femmes opérées de cholécystectomie pendant la période 1977–1981. La mortalité globale a été de 1.2%. La mortalité des femmes ayant eu une simple cholécystectomie se rapprochait de celle des femmes ayant eu une hystérectomie. Cette mortalité a été significativement plus importante dans cette population que dans la population féminine en générale (p 〈 0.05). L'âge élevé, l'admission en urgence, à moins de trois mois d'une première admission, le nombre de diagnostics retenus à la sortie, et la région géographique (éloignée ou pas) étaient des facteurs significativement associés avec une mortalité plus élevée. En analyse bifactorielle, la mortalité était significativement plus élevée en cas d'exploration de la voie biliaire principale, mais cette signification disparaissait lorsqu'on a pris en compte le nombre de diagnostics à la sortie. Le type d'hôpital et le taux de cholécystectomie selon la région géographique n'ont pas influencé la mortalité. La cholécystecomie élective est une opération sure avant l'âge de 50–60 ans. L'admission en urgence et l'incertitude diagnostique au moment de la sortie sont associés avec une mortalité plus importante. Par contre, l'exploration de la voie biliaire principale n'est peut-être pas un facteur indépendent aussi important qu'il n'est classique de le dire.
    Kurzfassung: Resumen Este artículo presenta la evaluación de mortalidad ocurrida en los primeros treinta días después de la hospitalización en 13.854 mujeres sometidas a colecistectomía como operación principal en el período 1977–81. La tasa global cruda de mortalidad fue 1.2%. Las mujeres sometidas a colecistectomía electiva simple tuvieron una tasa de mortalidad similar a la de las mujeres sometidas a histectomía simple. La tasa de mortalidad fue significativamente mayor que en la población femenina general (p 〈 0.05). Factores asociados con mortalidad aumentada fueron la edad mayor, hospitalización aguda, hospitalización en los 3 meses anteriores a la fecha de hospitalización para colecistectomía, el número de diagnósticos de egreso y la región geográfica. La exploración del colédoco apareció asociada con una mortalidad mayor en el análisis bivariable, pero tal asociación desapareció cuando se tuvo en cuenta el número de disgnósticos de egreso. El tipo de hospital y la tasa de colecistectomía basada en la población del área de residencia del paciente no aparecieron correlacionados con la mortalidad. En relación con mortalidad temprana, se puede concluir que la colecistectomía electiva simple es un procedimiento seguro en pacientes menores de 50–60 años. Las hospitalizaciones agudas y un número de diagnósticos de egreso mayor de uno aparecieron asociados con mortalidad incrementada, en tanto que la exploración del colédoco puede no ser un factor independiente de importancia, tal como previamente se asumía.
    Notizen: Abstract This paper assesses the risk of dying within 30 days of admission among 13,854 women who had a cholecystectomy performed as the principal operation from 1977 to 1981. The overall crude mortality rate was 1.2%. Women who had a simple elective cholecystectomy performed had a mortality rate similar to women who had a simple hysterectomy. The mortality was significantly higher than in the general female population (p 〈 0.05). Increased age, acute admission, admissions to hospital within 3 months prior to the index admission, the number of discharge diagnoses, and the geographical region were significantly associated with increased mortality. Exploration of the common bile duct was associated with higher mortality in the bivariate analysis, but the association disappeared when the number of discharge diagnoses was taken into account. Type of hospital and the population based cholecystectomy rate of the patient's residential area was not associated with mortality. As regards early mortality, it is concluded that simple elective cholecystectomy is a safe procedure before the age of 50 to 60 years. Acute admissions and more than one diagnosis at discharge were associated with an increased mortality, whereas exploration of the common bile duct may not be as important an independent factor as previously assumed.
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Acta neurochirurgica 124 (1993), S. 114-119 
    ISSN: 0942-0940
    Schlagwort(e): Adaptation ; cerebral blood flow ; hypercapnia ; hypoxia ; indomethacin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In a randomized study of healthy volunteers indomethacin bolus injection followed by continuous infusion decreased CBF from normal levels ranging from 45 to 80 ml/100 g/min to levels ranging from 24 to 57 ml/100 g/min. These low levels were sustained during a six hour infusion period. Periods of hypoxia during inhalation of 17% oxygen and hypercapnia during inhalation of 2–4% CO2 normalized CBF.
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Applied microbiology and biotechnology 41 (1994), S. 560-564 
    ISSN: 1432-0614
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Abstract A recombinant DNA Chinese hamster ovary (CHO) cell line that produces tissue-type plasminogen activator (tPA) was cultivated continuously in suspension with a constant dilution rate of 0.5 day with three different asparagine concentrations in the feed (0.05, 2.55 and 7.55 mm). The up-shift in asparagine concentration caused an up-shift in asparagine consumption [15.7 and 31.4 nmol (106 cells)−1 h−1] and intracellular concentration (2.19 and 18.7 mm). The up-shift was accompanied by an increased production of ammonium, glycine and alanine, and a metabolic shift whereby the cells began to produce aspartate and glutamate, which were consumed before the shift. The tPA production was reduced in the up-shift culture. This might be explained by ammonium inhibition, but alternatively by a surprising down-shift in the intracellular concentration of many amino acids, a down-shift that was not observed in the extracellular concentrations or consumption rates. For efficient physiological engineering of mammalian cells it is necessary to include both extracellular and intracellular measurements and to consider the transport into and out of the cells.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Archives of dermatological research 282 (1990), S. 38-41 
    ISSN: 1432-069X
    Schlagwort(e): PABA ; Sunscreening agent ; Ultraviolet carcinogenesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The efficacy of a 5% solution of para-aminobenzoic acid (PABA) to protect against photocarcinogenesis was tested in 6 groups, each of which contained 30 light pigmented hairless mice. The light source was a Phillips TL 40 W/12, which mainly emits UVB. PABA significantly retarded the tumor induction time (p〈0.05) and reduced both tumor yield and carcinoma yield (p〈0.05). The dorsal skin of the mice was removed and weighed. The mean weight of UVR-exposed mice skin protected with PABA did not differ from that of the controls, but in the non-protected UVR-exposed mice the skin samples were significantly heavier (p〈0.05).
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Bioprocess and biosystems engineering 9 (1993), S. 205-213 
    ISSN: 1432-0797
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Abstract Fed-batch cultivations of hybridoma cell cultures for antibody production were computer simulated by a detailed structured model, that divides the cell mass into four metabolic compartments and makes use of descriptions of the most important metabolic pathways. Surprisingly the simulations indicate, that online or frequent off-line control of fed-batch hybridoma cultures may lead to low and variable yields of antibody product. With less frequently controlled fed-batch cultures the system is more stable; and there is an optimal time interval for control, that depends on the feeds selected. The product yields in optimal fed-batch cultivations, however, are seldom higher than in comparable batch cultivations.
    Materialart: Digitale Medien
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  • 9
    ISSN: 1432-1238
    Schlagwort(e): CPAP ; PEP ; IR-PEP ; Chest physiotherapy ; Heart surgery ; Pulmonary surgery
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Objective An investigation into the incidence of post-operative complications after thoracic surgery with 3 different physiotherapy masks. Design A prospective, consecutive, randomized comparison. Setting Department of Thoracic and Heart Surgery at a University Hospital. The treatments were performed by experienced and specially trained physiotherapists. Patients 160 patients were evaluated. 60 patients undergoing heart surgery, 59 patients having pulmonary resection, and 41 patients with exploratory thoractomy. Interventions In each operative category the patients were treated with one of three face mask systems used in addition to routine chest physiotherapy. These were either continuous positive airway pressure (CPAP), positive expiratory pressure (PEP), or inspiratory resistance — positive expiratory pressure (IR-PEP). Measurements and results Post-operative pulmonary complications were assessed by forced vital capacity (FVC), arterial oxygen tension (PaO2), and chest X-ray examination, all measured pre-operatively and on the fourth and ninth post-operative day. The patients filled in a questionnaire expressing their opinion about their mask treatment. There was an equal decrease in FVC, FVC%, and PaO2, and equal frequency of atelectasis in the 3 mask treatments. More patients with the PEP mask favoured their system than did those with the other 2 systems. Conclusion There was no statistically significant difference between the treatments: continuous positive airway pressure (CPAP), positive expiratory pressure (PEP), and inspiratory resistance — positive expiratory pressure (IR-PEP) on post-operative complications. Any of the three treatments may be used as supplement to standard chest physiotherapy.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Geometriae dedicata 42 (1992), S. 205-213 
    ISSN: 1572-9168
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract The current smallest convex universal cover for sets of unit diameter is described. This reduction of Sprague's cover is by 4 · 10-11 and results in an asymmetrical cover. Another small universal cover of sets of unit diameter with an axis of symmetry reduces Sprague's cover by 0.0019. An indication is given of how to use computers in the solution of this kind of problem.
    Materialart: Digitale Medien
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