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  • Articles: DFG German National Licenses  (3)
  • 1990-1994  (3)
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  • Articles: DFG German National Licenses  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    GABAA Receptor Function in the Early Period After Transient Forebrain Ischaemia in the Rat (1993)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 5 (1993), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this study was to evaluate the function of the GABAA receptor following transient forebrain ischaemia. The GABA-stimulated chloride (36Cl−) uptake into synaptoneurosomes was determined as an indicator of GABAA receptor function. Synaptoneurosomes were isolated from control rats and rats in which the forebrain was made ischaemic by way of the two-vessel occlusion model. Animals subjected to ischaemia were killed at the end of the ischaemic insult and at 30 min or 2 or 5 h of recirculation. The results showed a reduction of 75% in GABA-mediated 36Cl− uptake in synaptoneurosomes isolated from animals shortly (〈0.5 h) after the ischaemic episode (P 〈 0.01). After longer recirculation periods the GABA-mediated 36Cl− uptake reached preischaemic control levels. To investigate whether alterations in 36Cl− uptake were related to the synaptoneurosomal metabolic status, the synaptoneurosomal ATP content was measured. The time course of the ATP recovery correlated with the recovery of the GABA-mediated 36Cl− uptake (r= 0.7, P 〈 0.001). To investigate the importance of ATP in GABA-mediated 36Cl−uptake more directly, synaptoneurosomes isolated from control rats were exposed to chemically induced ATP depletion with rotenone, an inhibitor of oxidative phosphorylation. This resulted in similar reductions in both ATP level and GABA-stimulated 36Cl− uptake as observed after in vivo ischaemia. These findings indicate that GABAA receptor function is transiently impaired in the early postischaemic period in a way which is closely related to alterations in cellular energy metabolism. The relevance of these findings to the development of ischaemic cell death is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.1993.tb00946.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Temporal evolution of focal cerebral ischemia in the rat assessed by T2-weighted and diffusion-weighted magnetic resonance imaging (1992)
    Springer
    Brain topography 5 (1992), S. 171-176 
    Details
    ISSN: 1573-6792
    Keywords: Cerebral ischemia ; Magnetic resonance imaging ; Brain edema ; Diffusion ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study was undertaken to characterize the formation of ischemic brain edema using diffusion-weighted and T2-weighted magnetic resonance imaging in a rat model of focal ischemia. The extent of edema formation was measured from multislice diffusion-weighted and T2-weighted spin-echo images acquired at various times after ischemia. The spin-spin relaxation time (T2) and the apparent diffusion coefficient in normal and ischemic tissue were also determined. The results show that on the diffusion-weighted images the lesion was clearly visible at 30 minutes after ischemia, while on the T2-weighted images it became increasingly evident after 2–3 hours. On both types of images the hyperintense area increased in size over the first 48 hours. After 1 week the hyperintensity on the diffusion-weighted images rapidly disappeared and evolved as a hypointense lesion in the chronic phase. These results confirm the high sensitivity of diffusion-weighted MRI for the detection of early ischemia. The temporal course of the edema observed on T2W-images is in agreement with the reported increase of total water content occurring in this model. The increase of the lesion observed on the diffusion-weighted images during the first 2 days points to an aggravation of cytotoxic edema that parallels the changes in free water shown by the T2-weighted images. It is shown that the highly elevated T2's of the infarcted area several days after ischemia can substantially contaminate the diffusion-weighted images.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01129046
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Focal ischemia in cat brain as studied by diffusion-weighted and dynamic susceptibility-contrast magnetic resonance imaging (1994)
    Springer
    Magnetic resonance materials in physics, biology and medicine 2 (1994), S. 367-370 
    Details
    ISSN: 1352-8661
    Keywords: diffusion-weighted MRI ; susceptibility contrast MRI ; ischemia ; brain ; blood flow ; cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics
    Notes: Abstract Diffusion-weighted and susceptibility-contrast-enhanced magnetic resonance imaging were used to monitor the development of focal ischemia in cat brain. Diffusion-sensitized imaging was used to assess early ischemic tissue damage which was confirmed for the latest time point (∼12 h) with postmortem histological analysis.T*2-sensitized FLASH was used to measure the first passage of a bolus of FeO particles. Gamma function fitting of ΔR*2-time curves resulted in 2D maps of relative hemodynamic parameters, including cerebral blood volume and flow. The present data provide indications for cerebral blood flow thresholds for acute as well as for delayed ischemic tissue damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01705274
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    Paper (German National Licenses)
    Fulltext
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