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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Intensive care medicine 20 (1994), S. 219-221 
    ISSN: 1432-1238
    Schlagwort(e): Buflomedil ; Acute intoxication ; Partial anticholinergic syndrome ; Neuroleptic action ; Mydriasis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A 15-year-old girl was admitted to ICU in a comatose state. She presented with mydriasis, areflexia, hypoxemia and seizures. She was immediately intubated and connected to a ventilator. The seizures were reversed with intravenous diazepam. CT scan was negative. EEG showed a diffuse fast activity and theta waves with spikes in the anterior and temporal regions, bilaterally. The gastric lavage was suggestive of drug ingestion. The patient completely recovered after 6 h of mechanical ventilation and supportive management. Mydriasis was still present after the resolution of neurological symptoms. The girl told us she had ingested 10 tablets (3 g–55 mg/kg) of Loftyl (buflomedil) for suicidal intention. The buflomedil concentrations at 2–3 h from ingestion were 24.8 mg/l in the blood, 324.4 mg/l in the urine and 6.9 mg/l in the gastric content. The p-desmethyl metabolite was also identified in the urine. Buflomedil is a rheological agent largely used as a vasodilator in some European countries. Some recent reports have emphasized the risk of acute intoxication with this drug. Relatively low doses (50–60 mg/kg) have been associated with an important neurological toxicity and a high mortality. We suggest that the clinical picture we observed might be related to a neuroleptic-type action of buflomedil. We bring to attention the risk of a large, uncontrolled diffusion of a drug capable to cause serious consequences at relatively low doses.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-1084
    Schlagwort(e): Chemoembolisation ; Embolisation, hepatic artery ; Hepatocellular carcinoma ; Iodised oil
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract To evaluate the effectiveness of transcatheter arterial embolisation (TAE) as a treatment of hepatocellular carcinoma (HCC) complicating cirrhosis, the survival of 27 untreated patients and 57 TAE-treated patients was compared. Clinical features, laboratory findings and tumour stage were comparable in the two groups of patients. TAE was undertaken with epirubicin, iodised oil and gelatine esponge. Cumulative survival rates at 6, 12, 24 and 36 months were 0.59, 0.47, 0.17 and 0.08 in the untreated group, and 0.87, 0.75, 0.40 and 0.19 in the TAE-treated group (P = 0.01). Patients with Child's grade B cirrhosis and patients with tumour smaller than 25% of the liver volume responded better to TAE. Twenty-four untreated patients and 25 TAE-treated patients died during the follow-up. The complication rate and mortality rate of TAE were 28% and 1.7% respectively. TAE prolongs the survival of patients with HCC complicating cirrhosis; prognosis depends on tumour stage and the degree of hepatic function impairment.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Intensive care medicine 18 (1992), S. 479-484 
    ISSN: 1432-1238
    Schlagwort(e): Unilateral lung atelectasis ; Double lumen tracheostomy tube ; Differential lung ventilation ; Monitoring selective respiratory mechanics ; Compliance ; Intrinsic PEEP
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Two patients with refractory hypoxemia due to unilateral lung atelectasis were treated with differential lung ventilation (DLV) through a Robertshaw-type, double-lumen tracheostomy tube. DLV was applied using two non-synchronized ventilators and maintained for 6 and 3 days, respectively. Ventilator settings were chosen in accord to the clinical, laboratory and chest X-rays results. Particularly, tidal volume and PEEP were set to avoid excessively high alveolar pressure and to obtain the highest possible value of compliance. We investigated the mechanical properties of the two lungs separately by measuring airway pressure and compliance of each lung before the beginning of DLV and at 0, 5, 24, and 48 h after. Initially we observed in both patients very low values of compliance (7–9 cm H2O/I) and a significant level of PEEPi (12–8 cm H2O) of the diseased lung, whereas PEEPi in the healthy lung was negligible. The clinical improvement was assessed by sequential chest X-rays and by significant improvement of arterial blood gas and PaO2/FiO2 ratios and was associated with a progressive increase of compliance (24–22 cm H2O/I) and by a fall of PEEPi levels (5–4 cm H2O) of the diseased lung. We also observed an improvement of S $$\bar v$$ O2, O2AVI, PVRI and $$\dot Q$$ va/ $$\dot Q$$ t values (Case 1). The tracheostomy tube used to apply DLV was very reliable, allowing easy nursing care and selective bronchial aspirations. We conclude that DLV is a very useful technique in unilateral lung pathology, and it can be a life saving procedure in selected patients, by supplying volume and PEEP more efficiently to the affected lung.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    ISSN: 1432-2277
    Schlagwort(e): Neurotoxicity, liver transplantation, cyclosporin ; Liver transplantation, neurotoxicity, cyclosporin ; Cyclosporin, neurotoxicity, liver transplantation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Neurological complications of cyclosporin (CyA) therapy are frequent, usually occurring within the 1st month after transplantation. Though leukoencephalopathy is one of them, it is rarely documented. Here we report the case of an anti-HCV-positive patient with cirrhosis who underwent liver transplantation and developed cyclosporin-induced leukoencephalopathy. The presenting symptoms were dysarthria, difficulty walking, and dysphagia. They were first noted 6 months after transplantation in association with an episode of recurrent HCV acute hepatitis. White matter abnormalities were evident on computed tomography (CT) scanning and magnetic resonance (MR) imaging. This condition improved to some degree after cyclosporin withdrawal. To our knowledge this is the second reported case of CyA neurotoxicity occurring late after liver transplantation. Moreover, the association with acute hepatitis suggests the possibility of graft dysfunction as a contributing and triggering factor.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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