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Digitale Medien

Imaging Bragg spectrometer for pinched plasma experiments (1994)

Hirano, K. ; Hisatome, N. ; Yamamoto, T. ; [weitere]

[S.l.] : American Institute of Physics (AIP)

Review of Scientific Instruments 65 (1994), S. 3761-3765

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ISSN: 1089-7623

Quelle: AIP Digital Archive

Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik

Notizen: A compact Bragg spectrometer for monochromatic imaging in the soft x-ray region was designed and examined. With this spectrometer, a pinhole image is simultaneously recorded with a monochromatic image. This makes it possible to easily identify the wavelength when the location of the soft x-ray source fluctuates from shot to shot, such as in the plasma focus and Z-pinch plasma. An rubidium acid phtalate (RAP) flat crystal was examined and monochromatic images of the argon K lines around 4 A(ring) were successfully obtained and displayed. The resolution power and dispersion obtained in situ were compared with the calculated values. © 1994 American Institute of Physics.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1063/1.1144503

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Digitale Medien

Induction of natural killer suppressive factor in murine peritoneal cavity by intraperitoneal bolus administration of high-dose cisplatin (2000)

Ishikawa, K. ; Shimoda, K. ; Shiraishi, N. ; [weitere]

Springer

International journal of clinical oncology 5 (2000), S. 48-53

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ISSN: 1437-7772

Schlagwort(e): Key words Cisplatin ; Natural killer cell activity ; Natural killer suppressive factor ; Peritoneal cavity ; Intraperitoneal chemotherapy

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Background. Intraperitoneal (i.p.) chemotherapy is frequently utilized in patients with advanced gastric cancer or peritoneal dissemination. We investigated whether i.p. administration of cisplatin at high or low doses would impair host local immunity with respect to the induction of natural killer (NK) cell suppressive factor in the murine peritoneal cavity. Methods. Cisplatin was administered at a total dose of 10 mg/kg according to two schedules: high-dose bolus injection (HB; 10 mg/kg) and low-dose consecutive injections (LC; 2 mg/kg daily for 5 days). The supernatant obtained from the peritoneal lavage fluid was added during normal splenocyte-mediated NK cytotoxicity assay. The phenotypes of peritoneal exudate cells were analyzed using anti-F4/80 monoclonal antibody (MAb) and anti-I-A MAb. Results. NK cell activity was significantly inhibited by the supernatant obtained from the HB group 7 days after the administration of cisplatin (40.6% of NK cell activity in controls; P 〈 0.05). This inhibition was partly restored by prostaglandin E2 (PGE2) antiserum (69.5% of NK cell activity in controls). NK cell activity was not inhibited at any point by exposure to the supernatant of the LC group. I-A− peritoneal macrophages were more abundant in the HB group than in the LC group (2.9 × 106 vs 4.6 × 105 on day 3; P 〈 0.05). Conclusion. These results suggest that intraperitoneal bolus administration of high-dose cisplatin induces NK suppressive factors, including PGE2, in the peritoneal cavity, whereas low-dose consecutive administration does not.