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  • 1
    ISSN: 1432-1912
    Schlagwort(e): Steroids ; [35S]TBPS binding ; Cortical membranes ; Prolactin ; Pituitary ; GABAA receptor complex
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary It has been shown previously that 5α-pregnan-3α-ol-20-one (5α3αP) can inhibit prolactin release from anterior pituitary gland cells in culture through an interaction with a specific modulatory site on the GABAA receptor complex in anterior pituitary gland membranes. In the present work, this receptor site has been labelled with [35S]t-butylbicyclophosphorothionate ([35S]TBPS) to enable a study of the relative binding affinities (RBA) of different steroids for the GABAA receptor complex to be made. We have found a high correlation (r = + 0.88) between the inhibition of [35S]TBPS binding to anterior pituitary membranes and the inhibition of [35S]TBPS binding to cerebral cortical membranes by nine different steroids. There was also a high correlation between the inhibition of prolactin release from anterior pituitary gland cells in culture by these steroids and the inhibition of [35S]TBPS binding to anterior pituitary membranes (r = + 0.99) or to cortical membranes (r = + 0.81). These observations suggest that the measurement of prolactin release from anterior pituitary gland cells in culture is a good indicator of the functional activity of drugs that bind to the allosteric modulatory TBPS-binding site on the GABAA-receptor complex.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Numerische Mathematik 51 (1987), S. 237-250 
    ISSN: 0945-3245
    Schlagwort(e): AMS(MOS): 65N30 ; CR: G1.8
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Summary Two families of mixed finite elements, one based on simplices and the other on cubes, are introduced as alternatives to the usual Raviart-Thomas-Nedelec spaces. These spaces are analogues of those introduced by Brezzi, Douglas, and Marini in two space variables. Error estimates inL 2 andH −s are derived.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 28 (1989), S. 1787-1801 
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: We present in this paper a procedure to establish Reissner-Mindlin plate bending elements. The procedure is based on the idea to combine known results on the approximation of Stokes problems with known results on the approximation of elliptic problems. The proposed elements satisfy the mathematical conditions of stability and convergence, and some of them promise to provide efficient elements for practical solutions.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 19 (1994), S. 275-294 
    ISSN: 0271-2091
    Schlagwort(e): Navier-Stokes ; Fully-coupled solution ; Iterative solvers ; Finite-element methods ; Parallel algorithm ; Block diagonal preconditioning ; CFD ; Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Notizen: This paper presents the parallelization aspects of a solution method for the fully coupled 3D compressible Navier-Stokes equations. The algorithmic thrust of the approach, embedded in a finite element code NS3D, is the linearization of the governing equations through Newton methods, followed by a fully coupled solution of velocities and pressure at each non-linear iteration by preconditioned conjugate gradient-like iterative algorithms. For the matrix assembly, as well as for the linear equation solver, efficient coarse-grain parallel schemes have been developed for shared memory machines, as well as for networks of workstations, with a moderate number of processors. The parallel iterative schemes, in particular, circumvent some of the difficulties associated with domain decomposition methods, such as geometry bookkeeping and the sometimes drastic convergence slow-down of partitioned non-linear problems.
    Zusätzliches Material: 15 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 6 (1986), S. 895-911 
    ISSN: 0271-2091
    Schlagwort(e): Free Surface Flow ; Mixed Finite Elements ; Choice of Velocity Approximation ; Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Notizen: New finite elements have been developed to simulate steady and unsteady two-dimensional free surface flows. The depth-averaged velocity components with the free surface elevation have been used as independent variables in the model. The differences between the various elements presented lie in the choice of velocity approximation. The Newton-Raphson method has been used to solve the non-linear system of equations. Emphasis is put on bench-mark examples to assess the accuracy and efficiency of the elements. A simple stable new element tested herein shows promising advantages for industrial finite element codes.
    Zusätzliches Material: 12 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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