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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 16 (1994), S. 399-407 
    ISSN: 1279-8517
    Keywords: Lymphatics ; Esophagus ; Thoracic duct ; Macroscopic anatomy ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Chez 106 cadavres de japonais adultes, nous avons mis en évidence, aussi bien macroscopiquement que microscopiquement, des vaisseaux lymphatiques péri-oesophagiens qui se drainaient dans le conduit thoracique. Macroscopiquement, le drainage lymphatique de l'oesophage dans le conduit thoracique existait chez 46 des 106 cadavres (43,4 %). 23 gros collecteurs ont été vus qui naissaient de l'oesophage thoracique et s'abouchaient directement dans le conduit thoracique chez 21 des 106 cadavres (19,8 %). Le plus souvent (15 des 23 gros collecteurs), ces lymphatiques reliaient l'oesophage au conduit thoracique au niveau des 1er-3ème ou des 6ème-8ème vertèbres thoraciques. D'après l'examen histologique de ces 23 gros collecteurs, 2 prenaient naissance à partir d'un fin plexus lymphatique de l'adventice de l'oesophage infiltré de cellules mononucléaires. Dans 11 cas sur 23, un lymphonoeud intermédiaire a été trouvé sur le conduit thoracique grâce à des “clearing methods”. Ces résultats suggèrent que la lymphe de l'oesophage se draine rapidement dans la circulation systémique par l'intermédiaire du conduit thoracique. Importantes en clinique dans le cancer de l'oesophage, les descriptions antérieures de lymphatiques extrapariétaux de l'oesophage ont été discutées à propos de ce drainage lymphatique direct de l'oesophage.
    Notes: Summary The lymphatic vessels from around the esophagus which drain into the thoracic duct were identified macroscopically and histologically in 106 cadavers. Direct lymphatic drainage to the duct was macroscopically demonstrated by 84 vessels in 46 cases (43.4%). In 23 cases (19.8%), large collecting vessels arose from the thoracic esophagus and opened directly imto the duct. In most of these cases (15/23) these lymphatic connections were found at the levels of the 1st–3rd or 6th–8th thoracic vertebrae. Histologic study revealed that two vessels originated from the fine lymphatic plexus in the esophageal adventita, which showed monocytic infiltration. In 11 of the 23 cases, an intercalated node was found along the thoracic duct. The results suggest that lymph drains rapidly into the systemic circulation via the thoracic duct. In view of the clinical applications in esophageal carcinoma, previous accounts of the extramural esophageal lymphatics concerned in direct drainage are discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1420-9071
    Keywords: Spongionella sp. ; porifera ; cell division inhibitor ; starfish embryos ; furanosesterterpene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Two novel furanosesterterpenes, okinonellins A (1) and B (2), have been isolated from the spongeSpongionella sp. Both compounds inhibit cell division of starfish embryos.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1420-9071
    Keywords: Gorgonian ; brianolide ; diterpene ; Briareum sp. ; antiinflammatory activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Brianolide (1), a new antiinflammatory diterpenoid of the briarein class, possessing a β substituent at C-12 (R), has been isolated from the Okinawan gorgonianBriareum sp. Its structure has been established from spectral data in conjunction with a single crystal X-ray analysis.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 151 (1992), S. 388-389 
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 144 (1985), S. 93-95 
    ISSN: 1432-1076
    Keywords: Moyamoya disease ; Arterial occlusive disease ; Short stature ; Syndactylia ; Cerebrovascular circulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We treated a Japanese boy with moyamoya disease accompanied by synbrachydactylia, funnel chest, pes equinus and short stature. Angiograms showed the anomalous origin of the occipital artery in addition to the moyamoya vascular network at the base of the brain. A generalised mesenchymal anomaly was suggested in this case.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1041
    Keywords: 6-Mercaptopurine ; suppository ; bioavailability ; acute lymphoblastic leukaemia ; children ; interindividual variability ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma levels and the area under the plasma concentration-time curve (AUC) values of 6-mercaptopurine (6-MP) were determined in a balanced crossover study of oral (powder) and rectal (macrogol suppository) administration to 5 children with acute lymphoblastic leukaemia (ALL). The AUC (538.6 ng · h · ml−1) after the rectal dose of 30 mg/m2 was approximately 1.5-times of that (365.5 ng · h · ml−1) after the oral dose of 87.5 mg/m2. The coefficients of variation of interindividual variability of the AUCs were 21.5% and 32.3%, respectively. The relative bioavailability of the macrogol suppository compared to the powder was approximately 4.39. These findings indicate that rectal administration of 6-MP could avoid the first-pass effect of this drug in the alimentary canal and/or liver, resulting in a large AUC of 6-MP, and so could reduce interindividual variability in plasma 6-MP concentrations. Rectal administration of 6-MP may be more effective than empirical oral dosing for the treatment of children with ALL, especially for patients with nausea and/or vomiting.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0942-0940
    Keywords: Dural AVM ; embolization ; aron alpha ; cyanoacrylate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors report four cases of dural arteriovenous malformation (AVM) treated by a modified technique of embolization. Three cases had posterior fossa dural AVM and one had bilateral supratentorial dural AVM. The authors think that the best way to treat dural AVM is to close its nidus completely. This could be achieved by a safe and easy technique of embolization. The material used for embolization should intimately adhere to the vascular network and should not become fragmented. We used aron alpha (Ethyl-2-cyanoacrylate). This is a biological glue and it sets in a solid membranous form instantaneously on coming into the contact with an ionic medium. It does not get fragmented. Aron alpha was injected into the nidus of the AVM through a cannula inserted only into the main feeding artery in four cases of dural AVM reported here. Postoperative angiography showed complete obliteration of the AVM's, they did not fill either from the treated artery or from the untreated feeding arteries. The technique is easy and safe. There was no operative or postoperative complication. All the patients have remained asymptomatic to date,i.e. 2, 2, 6 and 7 1/2 years after the procedure.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 98 (1989), S. 184-188 
    ISSN: 0942-0940
    Keywords: Autoregulation: pial vessels ; ventricular fluid pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The behaviour of Pial vessels to levels of CSF-pressure between 10 and 100 mmHg induced by vetricular infusion of mock CSF, was observed in 6 cats under barbiturate and N2O anaesthesia, using the cranial window technique and videoangiometry. Supratentorial pressure (STP) equaled infratentorial pressure in the cisterna magna (CMP) throughou. No changes in pial arterial calibres were noted up to a CMP of 13 mmHg (i.e. a cerebral perfusion pressure (CPP) of 100 mmHg). Further increase of CMP to 45 mmHg induced significant arterial dilatation of 40 ± 3.4%. With a further rise of ventricular fluid pressure (VFP) no marked further arterial dilatation occurred. Dilatation of arteries up to 100 um resting diameter and arteries between 100 and 250 um resting diameter and arteries between 100 and 250 um was not significantly different. When CPP approached 40 mmHg, arteries were still 47 ± 3.6% dilated. Pial venous calibre did not vary by more than 20% during elevation of VFP. At CPP 47 mmHg, small and large veins were dilated by 14%. Single venous segments were compressed by crossing pial arteries and caused upstream venous congestion and distension.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 109 (1991), S. 52-56 
    ISSN: 0942-0940
    Keywords: Sagittal sinus pressure ; CSF-pressure ; pial vessels ; autoregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using parietal cranial windows and multichannel videoangiometry, pial vessel responses were studied in cats during stepwise elevation of superior sagittal sinus pressure (PSSS) to a level of 50 mmHg or reduction of CSF-pressure (PCSF). PCSF was monitored via a needle in the great cistern, known from previous studies to be identical to supratentorial CSF-pressure. During elevation of PSSS, large and small pial veins dilated by 14±6.1% from resting diameter. Small arteries remained unresponsive until they were dilated by 9±2.1% at the level of PSSS 50mmHg. Large arteries dilated by 18±5.5% at the level of PSSS 50 mmHg. PSSS was always approximately twice as high as PCSF during increase of PSSS. During reduction of PCSF to − 5 mmHg, pial veins also dilated, by 7.4±1 % on the average. This observation suggests that normal PCSF is a result of mainly venous vascular pressure, and that the level of normal venous pressure is not dictated by PCSF but by the function and architecture of the cerebral vasculature. Since the rapid reduction of cerebral perfusion pressure CPP by elevation of venous pressure does not induce autoregulatory adjustment according to the level of CPP, but to the level of arterial transmural pressure, it is concluded, that the basic mechanism underlying autoregulation of CBF is myogenic.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 73-75 (Jan. 1991), p. 685-692 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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