ZIB

Treffer pro Seite

Treffer 1 - 1 | 1 Treffer

Sortierung

Digitale Medien

Frequency and DNA sequence of tal-1 rearrangement in children with T-cell acute lymphoblastic leukemia (1992)

Borkbardt, A. ; Repp, R. ; Harbott, J. ; [weitere]

Springer

Annals of hematology 64 (1992), S. 305-308

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1432-0584

Schlagwort(e): T-cell acute lymphoblastic leukemia ; Gene rearrangement ; Minimal residual disease

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Using nested polymerase chain reaction (PCR) a gene rearrangement named tal-1 deletion was found in five of 56 leukemic bone marrow samples from children with T-cell acute lymphoblastic leukemia (ALL). The DNA sequences of the PCR fragments consisted of the known conserved germline sequences in addition to short DNA insertions at the breakpoint region, which were different in each patient. Moreover, one patient was examined at diagnosis and at relapse 11 months later, revealing identical DNA sequences at the rearrangement site. The recombination site of the tal rearrangement therefore may be used as a genetic marker for detecting minimal residual disease in about 10% of T-cell ALL in childhood.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01695477

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Treffer 1 - 1 | 1 Treffer