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  • 1
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 72 (1992), S. 1821-1832 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Electrical resistance of Al-1 wt % Si thin-film conductors has been measured as a function of time t, temperature, and current polarity in order to investigate both generation and recovery of (microstructural) damage caused by electromigration. The fractional change of electrical resistance ΔR/R is characterized by three distinct stages: (i) undetectable ΔR/R during an incubation period τ; (ii) linear increase of ΔR/R with t−τ; and (iii) abrupt decrease of ΔR/R when polarity is reversed, followed by gradual resumption of the previous linear increase. Examination of the conductor surface during these three stages by scanning electron microscopy reveals: (i) undetectable microstructural damage; (ii) generation of (first) holes and (then) hillocks; and (iii) recovery followed by further generation of microstructural damage. Results are interpreted by (i) generation of stress σ in grain boundaries; (ii) formation of holes when σ exceeds a critical tensile stress σ+c and hillocks when σ exceeds a critical compressive stress σ−c (||σ+c|| 〈 ||σ−c||), and (iii) interchange of tensile and compressive stress by polarity reversal. The last stage, in fact, represents superposition of a continuation of the linear increase (degradation) of ΔR/R due to the applied current and an exponential decrease (healing) of ΔR/R, characterized by τ, due to stress relaxation. In general, damage and subsequent healing by electromigration involve a delicate balance between applied current, time, and spatial distribution of (elastic) tensile and compressive stress, (anelastic) formation of holes, and (plastic) formation of hillocks, as dictated by the concomitant microstructure.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Pediatric allergy and immunology 4 (1993), S. 0 
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In order to identify newborns at risk for atopic diseases, we developed a family questionnaire and selected specific answers which were suitable to identify atopic family members. The validity of the questionnaire was evaluated by the Phadiatop lest results of 793 mothers and 353 fathers. As both screening instruments do not measure the same, the Phadiatop test identifies scnsitization to inhalant allergens and the history reflects the clinical manifestation of atopic disease, the agreement between sensitization and manifestation is incomplete. Sensitivity and specificity of the questionnaire screening conditions to reproduce the Phadiotop lest result was 64% and 84% for mothers, and 58% and 88% for fathers, respectively. The relative risk for lifetime prevalence of atopic manifestations in Phadiatop positive over negative mothers was calculated to be 3. 88 (95% confidence interval = 3. 12 to 4. 81), and for Phadiatop positive over negative fathers to amount 4. 84 (95% confidence interval 3. 25 to 7. 23). A few relevant answers of 20 were identified by logistic regression analysis to predict the Phadiatop test result nearly, as well as the total questionnaire.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 61 (1992), S. 2987-2989 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Steady-state electromigration along grain boundaries in a monatomic polycrystalline thin film has been analyzed in a two-dimensional model by balancing the (applied) electric and (induced) stress driving forces to achieve a zero flux divergence. The continuity of chemical potential requires a unique stress normal to each of the three boundaries terminating at a given triple point. These stresses and the steady-state fluxes are determined by a set of linear equations subject to boundary conditions at the intersection of grain boundaries with the film edge (edge points). When the normal stress is assumed zero at all edge points, the stress typically attains maxima and minima at triple points, whereas, when the flux is assumed zero at all edge points, the stress typically builds up monotonically in the field direction.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 61 (1992), S. 276-278 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Time evolution of the fractional change of electrical resistance of passivated Al–1 wt% Si thin-film conductors is characterized by five distinct stages: (1) undetectable change during an incubation period, (2) subsequent linear increase, (3) saturation, (4) abrupt decrease when applied current is interrupted or reversed, and (5) erratic fluctuations at extended times. Results are interpreted in terms of generation of localized tensile and compressive stress by electromigration, resulting in (reversible) hole formation at grain boundary triple junctions, followed by complex combinations of hole movement, coalescence, and annihilation.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 58 (1991), S. 2354-2356 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The formation and growth of holes and hillocks at grain boundary triple junctions in thin-film conductors of gold on gallium arsenide and thin-film conductors of aluminum-1 wt. % silicon on (oxidized) silicon during the early stages of electromigration have been investigated through measurement of fractional change of electrical resistance ΔR/R and microstructural characterization by scanning and transmission electron microscopy. Each grain boundary triple junction is characterized by a unique structure factor ΔY, which defines the degree of cumulative flux divergence and, consequently, the degree of susceptibility to formation and growth of holes or hillocks. Resultant holes are characterized by a shape factor f, which defines the degree of noncircularity and, consequently, relates fractional change of hole area to ΔR/R. Estimates of the upper limit for ΔY and the average value of f are in good agreement with measured values of ΔR/R and consistent with observed microstructure.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of plastic surgery 14 (1991), S. 3-6 
    ISSN: 1435-0130
    Keywords: Skin flap ; Calcium channel blockers ; Ischemia ; Animal models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study was designed to evaluate the influence of two calcium channel blockers, verapamil and nifedipine, on skin flap survival. These agents were selected because they inhibit the passage of calcium through calcium selective channels in the plasma membrane, thereby blocking calcium mediated electromechanical coupling in contractile tissue and resulting in peripheral arterial vasodilation. Three groups of pigs were used in this study. All skin flaps in this study were 3 cm wide and 12 cm long. The first group (10 flaps) served as controls with no pharmacologic manipulations. Pigs in group II (15 flaps) received verapamil (80 mg orally, three times a day) for 7 days postoperatively. Pigs in group III (15 flaps) received nifedipine (10 mg orally, three times a day) for 7 days postoperatively. Statistical analysis of the results demonstrated that both verapamil and nifedipine resulted in significant enhancement of skin flap survival. The increased survival of the skin flaps produced by nifedipine as compared to verapamil was statistically significant.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-2013
    Keywords: Isolated perfused kidney ; Radioimmunoassay ; Hypoxia ; Renal oxygen sensing ; cAMP ; cGMP ; Calmodulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study we have investigated the role of oxygen delivery and of classic second messengers on erythropoietin production by the isolated perfused rat kidney. We found that the rat kidney was capable of de novo synthesis of erythropoietin. The erythropoietin production rate was inversely related to the oxygen pressure in the perfusate and increased from 0.17 to 1.85 U erythropoietin h−1 g kidney−1 when arterial PO2 was lowered from 500 mmHg to 30 mmHg. Addition of forskolin (10 μM) and 8-bromo-cGMP (100 μM) to the perfusate elicited significant effects on the renal vascular resistance, but had no significant effect on erythropoietin production. Hypoxia-induced erythropoietin formation, however, was blocked by calmidazolium (1 μM) and W-7 (10 μM), two structurally different putative calmodulin antagonists. Calmidazolium and W-7 had no effect on other functional parameters of the isolated perfused rat kidney such as flow rate, glomerular filtration rate or sodium reabsorption. Our findings suggest that the oxygen-sensing mechanism that controls renal erythropoietin production is primarily located in the kidney itself. A calcium/calmodulin-dependent cellular reaction could be involved in the signal transduction process.
    Type of Medium: Electronic Resource
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