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  • 1
    Electronic Resource
    Electronic Resource
    Autologous and allogeneic bone marrow transplantation in acute myeloid leukemia in first complete remission: an update of the Genoa experience with 159 patients (1992)
    Springer
    Annals of hematology 64 (1992), S. 128-131 
    Details
    ISSN: 1432-0584
    Keywords: AML in first CR ; ABMT ; BMT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the attempt to evaluate the role of Autologous and Allogeneic Bone Marrow Transplantation, we have retrospectively analyzed 159 patients with Acute Myeloid Leukemia in first complete remission treated in our Unit, most of whom were referred from other Institutions. High-dose therapy was uniform and consisted of cyclophosphamide 60 mg/kg/d on two consecutive days and TBI in a single dose (10 Gy) for ABMT patients and in fractionated doses (3.3 Gy × 3 days) for BMT patients. Eight years actuarial survival was similar in two groups (52% for BMT and 49% for ABMT). The actuarial risk of relapse for BMT and ABMT was 29% and 43%, respectively. Considering that none of ABMT patients was “purged” with in vitro technique, this review seems to confirm the importance of “in vivo” purging with postremission intensification, immediately before the harvesting. Of course, more patients and a longer follow-up are needed to drow final conclusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01697399
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  • 2
    Electronic Resource
    Electronic Resource
    Cyclosporine-induced graft-versus-host disease after autologous bone marrow transplantation in hematological malignancies (1991)
    Springer
    Annals of hematology 62 (1991), S. 156-159 
    Details
    ISSN: 1432-0584
    Keywords: CyA ; ABMT in hematological neoplasias ; GVHD
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the attempt to induce graft-vs-host disease (GVHD) in patients undergoing autologous bone marrow transplantation (ABMT) or blood stem cell transplantation (BSCT), 12 consecutive patients received cyclosporin A (CyA) post transplant. CyA was given at a dose of 1.5 mg/kg/day intravenously for 28 days, starting on the day of transplant. Histologically proven acute GVHD of the skin occurred in seven patients 9–14 days after ABMT and lasted 7–11 days. CyA-induced GVHD after ABMT resembles mild GVHD after allogeneic bone marrow transplantation (BMT). Although the preliminary data reported here show that it is possible to induce GVHD in patients undergoing ABMT, it is not yet known whether GVHD after ABMT will have an antitumor activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01703140
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Magnetic resonance angiography monitoring of streptokinase in occlusion of the middle cerebral artery (1993)
    Springer
    Neurological sciences 14 (1993), S. 629-632 
    Details
    ISSN: 1590-3478
    Keywords: Magnetic Resonance Imaging ; streptokinase ; occlusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Una donna di 77 anni fu ricoverata a distanza di un'ora dall'insorgenza di emiplegia destra con afasia. Una Risonanza Magnetica dell'encefalo risultò negativa, mentre una Angio-RM indicava l'occlusione dell'arteria cerebrale media di sinistra; fu quindi intrapresa la terapia con streptokinasi. Dopo due ore dall'infusione, le capacità motorie della paziente migliorano sensibilmente. Una Angio-RM effettuata sei ore più tardi evidenziò la parziale ricanalizzazione del vaso occluso. Questo caso dimostra la potenziale utilità del monitoraggio con Angio-RM nel corso della terapia trombolitica.
    Notes: Abstract A 77 year old woman was hospitalized one hour after the onset of right hemiplegia and aphasia. Magnetic resonance imaging (MRI) examination was negative and MRA indicated occlusion of the left middle cerebral artery. Treatment with streptokinase was instituted (a 60 minute intravenous infusion of 1.5 MU of streptokinase in 100 ml of saline solution). Two hours after infusion, the patient's motor function clearly improved. An MRA examination performed six hours later showed partial recanalization of the obstructed vessel. Our report demonstrates the potential usefulness of MRA monitoring during thrombolytic therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02339247
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  • 4
    Electronic Resource
    Electronic Resource
    Neuro-Behçet: Clinical features and MRI correlates (1993)
    Springer
    Neurological sciences 14 (1993), S. 61-67 
    Details
    ISSN: 1590-3478
    Keywords: Neuro-Behçet ; nuclear magnetic resonance (NMR) ; immunosuppressive and steroid therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Questo lavoro mette in risalto il ruolo fondamentale della RMN nella diagnosi delle complicanze neurologiche della malattia di Behcet. Gli autori presentano quattro casi clinici esaminati tra il 1990 e il 1991. In tutti i casi la terapia sembra aver migliorato la prognosi dei pazienti.
    Notes: Abstract This paper highlights the fundamental role of MRI in the diagnosis of Neuro-Behçet disease. We present 4 cases examined between 1990 and 1991. Treatment in all the cases seems to have improved the patients' prognoses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02339044
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  • 5
    Electronic Resource
    Electronic Resource
    Cerebral ischemia: Magnetic resonance angiography and transcranial Doppler evaluation (1994)
    Springer
    Neurological sciences 15 (1994), S. 39-47 
    Details
    ISSN: 1590-3478
    Keywords: MRA ; cerebral ischemia ; TCD
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Abbiamo esaminato 21 pazienti affetti da patologia cerebro-vascolare ischemica con Angio-RM e Doppler Transcranico. In 17 pazienti (81%) i dati ottenuti con le due metodiche sono risultati concordanti. L'uso associato del Doppler Transcranico e dell'Angiografia a Risonanza Magnetica può permettere, a nostro avviso, una accurata valutazione diagnostica del paziente affetto da stroke ischemico consentendo l'individuazione della sede della eventuale patologia steno-occlusiva dei vasi cerebrali di medio e grosso calibro oltre alla possibilità di ottenere informazioni di tipo dinamico riguardanti la direzione del flusso ematico in presenza di eventuali circoli di compenso a livello del poligono di Willis.
    Notes: Abstract We examined 21 patients with ischemic cerebrovascular disease using magnetic resonance angiography and transcranial Doppler. In 17 patients (81%), the results obtained by the two methods were concordant. In our opinion, the associated use of transcranial Doppler and magnetic resonance angiography provides an accurate diagnostic evaluation of ischemic stroke patients, not only allowing the site of possible steno-occlusive disease of large and medium cerebral vessels to be identified, but also offering the possibility of obtaining dynamic information concerning the direction of blood flow in the presence of compensatory circulations at the level of Willis' circle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02343495
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    Paper (German National Licenses)
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