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Role of resident macrophages in canatoxin-induced in vivo neutrophil migration (1992)

Barja-Fidalgo, C. ; Carlini, C. R. ; Guimarães, J. A. ; [et al.]

Springer

Inflammation 16 (1992), S. 1-12

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ISSN: 1573-2576

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Canatoxin (Cntx), a toxic protein purified fromCanavalia ensiformis seeds, was shown to have lipoxygenase-mediated effects either in vivo or in vitro. Data here show that Cntx induced a dose-dependent migration of neutrophils and mononuclear cells when injected into rat peritoneal cavities. Furthermore, Cntx was able to induce neutrophil migration into pleural cavities and into air pouches. These effects were inhibited by dexamethasone but not by inhibitors of arachidonic acid metabolism (indomethacin, NDGA, and BW-755c) or by a PAF antagonist (BN 52021). In the peritoneal cavity Cntx caused an increase in vascular permeability inhibited by dexamethasone and BW-755c. Neutrophil migration induced by this toxin was dependent on the number of resident macrophages, since the migratory effect was enhanced by increasing the peritoneal macrophage population with thioglycollate pretreatmen; and was diminished when this population was reduced by peritoneal wash. It was also observed that Cntx induced release of a chemotactic factor from macrophage monolayers in vitro. Dexamethasone blocked this release but did not affect in vivo neutrophil recruitment induced by that factor. These data suggest that Cntx-induced neutrophil migration may be mediated by the same macrophage-derived neutrophil chemotactic factor released by other stimuli such as LPS, IL-1, and INF-gamma.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00917510

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Measurement method and apparatus for monitoring the kinetics of polymerization and crosslinking reactions by microwave dielectrometry (1990)

Carlini, C. ; Rolla, P. A. ; Tombari, E.

New York, NY [u.a.] : Wiley-Blackwell

Journal of Applied Polymer Science 41 (1990), S. 805-818

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ISSN: 0021-8995

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics

Notes: The experimental apparatus employed for monitoring fast polymerizing and crosslinking processes is described in detail. The measurement method for the particular application is widely discussed and the resulting performances of the measurement technique are reported. As an example, the experimental results for polymerization and crosslinking reactions of n-butyl acrylate and 1,6-hexandiol-diacrylate are shown and the accuracy of the data acquisition is demonstrated.

Additional Material: 8 Ill.