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  • 1
    Electronic Resource
    Electronic Resource
    Phospholipase A2-catalysed modification of plasma low density lipoproteins caused reduction of hypercholesterolemic rabbit plasma cholesterolin vivo (1992)
    Springer
    Journal of materials science 3 (1992), S. 5-9 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Phospholipase A2 (PLA2) hydrolyses certain phospholipids of low density lipoproteins. PLA2-treated LDL is known to be rapidly cleared from plasma. A prototype plasma filter containing immobilizedCrotalus atrox PLA2 on agarose beads was developed. After a 90 min treatment with the extracorporeal device, plasma cholesterol concentration in cholesterol-fed NZW rabbits decreased by 32%. The decrease was dependent on the enzymatic activity in the plasma filter. The decrease in plasma cholesterol of hypercholesterolemic rabbits that were treated with control reactors (agarose beads only) was 5%. White and red blood cell counts and platelets remained unchanged during the treatment. Plasma cholesterol reduction (25–40%) was also obtained following intravenous injection of active PLA2 to modify plasma lipoproteins. PLA2 infusion created a radical change in biliary composition. Bile phospholipid composition was 90–95% lysophosphatidylcholine as compared with more than 95% before injection of active PLA2. Phospholipid and bile salts total mass increased by 10%. While biliary secretion rate of protein increased by 10%, biliary secretion rate of cholesterol remained unchanged. This technique is specific for lipoproteins, does not require any fluid replacement of sorbent regeneration, and offers a potential new approach for lowering serum cholesterol and LDL levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00702937
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Feeding postures of suspension-feeding larval black flies: the conflicting demands of drag and food acquisition (1991)
    Springer
    Oecologia 85 (1991), S. 457-463 
    Details
    ISSN: 1432-1939
    Keywords: Suspension-feeding ; Boundary layers ; Drag ; Conflicting demands ; Larval black flies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We tested whether larval black flies actively control the positioning of their feeding appendages (labral fans), and if so, whether their posture represents a balance between the conflicting demands of drag and feeding. We compared the postures of live larvae with the postures of larvae killed by heat-shock in three different flow regimes in a laboratory experiment; we assumed that the postures of heat-killed larvae approximated a passive response to drag. The average height of the labral fans above the bed declined significantly in faster flows, and was significantly greater in live than dead larvae. There was also a significant interaction effect, since the difference between the fan heights of live and dead larvae was greater in slower flows. Two mechanisms may contribute to this result. Larvae in slower flows have to increase their fan heights more than larvae living in faster flows to achieve comparable increases in velocity and thus particle flux. In addition, muscular strength may limit the feeding postures larvae can assume. The fan heights of live larvae also varied depending on the concentration of food particles: larvae exposed to low food concentrations held their fans higher above the bed than did larvae exposed to high food concentrations in the same flow regime. This change in posture is due neither to an uneven particle concentration in the boundary layer nor to added drag from particles trapped in the labral fans. Collectively, our results indicate that these suspension feeders actively control their feeding posture, and suggest that these varying postures represent a dynamic balance between the conflicting needs of minimizing drag and maximizing feeding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00323756
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Congenital ossifying fibroma (osteofibrous dysplasia) of the tibia —a case report (1991)
    Springer
    Pediatric radiology 21 (1991), S. 449-451 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ossifying fibromas of the long bones of the leg are benign lesions occurring in the pediatric age group identical in histological appearance to the similarly named tumor of the jaw in adults. Most frequently presentation occurs after minor trauma with symptoms of a swelling of the tibia or fibula which may be painful. Pathological fracture or limp are also occasional presentations. Congenital cases are extremely rare. We describe an otherwise normal male neonate who presented at birth with a bowed right lower leg. The limb was 1 cm shorter than the other side, with tibia vara and a firm mass situated anteriorly. X-ray showed a mixed lytic and sclerotic lesion in the proximal metaphysis of the tibia. Biopsy showed collagenous stroma containing spindle cells and irregular trabeculae of woven bone rimmed by plump osteoblasts. As the appearances were typical of an ossifying fibroma (osteofibrous dysplasia) no surgical treatment was given. The patient was well with no growth of the tumor and with radiological evidence of healing at 1 year follow up. This case is presented to draw attention to the clinicopathological features of this unusual lesion which must be considered in the differential diagnosis of congenital lesions of the tibia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02026689
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    Paper (German National Licenses)
    Fulltext
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