ISSN:
1420-9071
Keywords:
Substance P
;
fibrinolysis
;
plasminogen
;
α2-antiplasmin
;
healthy humans
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Physiological saline with or without substance P (50 ng/ml) was infused into the humeral artery in 6 healthy males. Indices of fibrinolytic activity (whole blood diluted lysis time, euglobulin lysis time, lysis areas in non-heated fibrin plates produced by plasma or euglobulin precipitate, plasminogen plasma levels, α2-macroglobulin, Cl-inhibitor, and α2-antiplasmin) were evaluated in the homolateral antecubital vein before and after 5 min of substance P or saline infusion. After substance P the fibrinolytic activity increased, as can be seen from the shortening of lysis times (p〈0.01) and enlargement of the lysis areas (p〈0.01). A reduction of plasminogen plasma levels (p〈0.01), associated with a decrease in α2-anitplasmin (p〈0.01), was also found. Alpha2-macroglobulin and Cl-inhibitor were instead unaltered by the peptide. The saline infusion, on the other hand, was unable to modify any of the examined indices. We concluded that exogenous substance P given intra-arterially increases fibrinolytic activity in locally-sampled venous blood through a mechanism which remains to be elucidated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01923533
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